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Institution

Cochin University of Science and Technology

EducationKochi, Kerala, India
About: Cochin University of Science and Technology is a education organization based out in Kochi, Kerala, India. It is known for research contribution in the topics: Thin film & Natural rubber. The organization has 5382 authors who have published 7690 publications receiving 103827 citations. The organization is also known as: CUSAT & Cochin University.


Papers
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Journal ArticleDOI
TL;DR: It is found that rituximab therapy can help pemphigus patients even after 6 years, in part by reshaping the B cell repertoire during reconstitution, allowing for long-term effects in addition to the short-term loss of pathogenic B cells.
Abstract: Pemphigus is a severe blistering condition of the skin and mucosa caused by autoantibodies directed against desmogleins, which are a type of keratinocyte adhesion protein. B cell depletion by rituximab has short-term efficacy against pemphigus. We aimed to assess the long-term course of pemphigus patients after B cell depletion and to understand the immunological mechanisms that mediate long-lasting remissions. We evaluated the clinical course of 22 pemphigus patients treated with rituximab after a 79-month median follow-up and compared the anti-desmoglein B cell response and B and T lymphocyte subpopulations and repertoire between patients who achieved complete remission (CR) and those who had incomplete remission (IR). Thirteen patients (59%) experienced CR during the study, including 10 patients off treatment and 3 patients with prednisone doses <10 mg/day; 9 patients had IR. A marked increase was observed in the ratio of CD19(+)CD27(-) naive B cells to CD19(+)CD27(+) memory B cells. Indeed, patients in CR had a fourfold higher number of transitional B cells and interleukin-10-secreting regulatory B cells than those in IR. Furthermore, CR was associated with modification of the initial B cell repertoire and the disappearance of desmoglein-specific circulating immunoglobulin G-positive (IgG(+)) B lymphocytes, whereas a skewed B cell repertoire was observed in patients in IR. Thus, a blockage of B cell maturation, a prolonged repopulation with naive B cells, and a delayed reappearance of memory B cells, which resulted in the disappearance of circulating desmoglein-specific IgG(+) B lymphocytes, contribute to the long-lasting effectiveness of rituximab for treating pemphigus.

195 citations

Journal ArticleDOI
TL;DR: Extensive unlimited intensive care support is justified for allogeneic HSCT recipients with complications occurring during the engraftment period, and initiation or maintenance of mechanical ventilation is questionable in the setting of active GVHD.
Abstract: Purpose Because the overall outcome of critically ill hematologic patients has improved, we evaluated the short-term and long-term outcomes of the poor risk subgroup of allogeneic hematopoietic stem-cell transplantation (HSCT) recipients requiring admission to the intensive care unit (ICU). Patients and Methods This was a retrospective multicenter study of allogeneic HSCT recipients admitted to the ICU between 1997 and 2003. Results Two hundred nine critically ill allogeneic HSCT recipients were included in the study. Admission in the ICU occurred during the engraftment period (≤ 30 days after transplantation) for 70 of the patients and after the engraftment period for 139 patients. The overall in-ICU, in-hospital, 6-month, and 1-year survival rates were 48.3%, 32.5%, 27.2%, and 21%, respectively. Mechanical ventilation was required in 122 patients and led to a dramatic decrease in survival rates, resulting in in-ICU, in-hospital, 6-month, and 1-year survival rates of 18%, 15.6%, 14%, and 10.6%, respectiv...

193 citations

Journal ArticleDOI
TL;DR: Significant improvements in the Young's modulus and tensile strength of the nanocomposite were observed because of the reinforcing ability of the nanocellulose in the rubber matrix.

192 citations

Journal ArticleDOI
TL;DR: Control of C/N ratio by the addition of a carbohydrate source to the pond water column benefited the extensive shrimp culture practices in three ways: increased heterotrophic bacterial growth supplying bacterial protein to augment the shrimp production, reduced demand for supplemental feed protein and subsequent reduction in feed cost and reduced toxic inorganic nitrogen levels in the pond as well as effluents.

191 citations

Journal ArticleDOI
TL;DR: The vibrational spectra confirm the existence of NH3(+) in glycinium oxalate and indicates the presence of peculiar intermolecular C-H...O hydrogen bonding interaction producing "blue shift" of C- H stretching frequency.

190 citations


Authors

Showing all 5433 results

NameH-indexPapersCitations
Pulickel M. Ajayan1761223136241
Maxime Dougados134105469979
Sabu Thomas102155451366
Philippe Ravaud10161841409
David P. Salmon9941943935
Jérôme Bertherat8543824794
Luc Mouthon8456426238
Xavier Bertagna7428518738
Alfred Mahr7322922581
Nicolas Roche7262922845
Charles Chapron7137818048
Benoit Terris6123413353
François Goffinet6053214433
Xavier Puéchal6031613240
Pascal Laugier5848210518
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202318
2022106
2021753
2020613
2019503
2018439