Institution
Cochin University of Science and Technology
Education•Kochi, Kerala, India•
About: Cochin University of Science and Technology is a education organization based out in Kochi, Kerala, India. It is known for research contribution in the topics: Thin film & Natural rubber. The organization has 5382 authors who have published 7690 publications receiving 103827 citations. The organization is also known as: CUSAT & Cochin University.
Topics: Thin film, Natural rubber, Microstrip antenna, Dielectric, Catalysis
Papers published on a yearly basis
Papers
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TL;DR: The studies suggest that curcumin plays a vital role in regulating the activity of cholinergic and insulin receptors and mechanism of glucose transportation through Glut3, which results in normalizing the diabetes-mediated cerebellar disorders.
58 citations
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TL;DR: It is demonstrated that the MEPE-derived ASARM peptide inhibits both odontogenic differentiation and matrix mineralization, while increasing MEPE expression, contributing to a partial mechanistic explanation of XLH pathogenesis.
Abstract: Mutations in PHEX (phosphate-regulating gene with homologies to endopeptidases on the X-chromosome) cause X-linked familial hypophosphatemic rickets (XLH), a disorder having severe bone and tooth dentin mineralization defects. The absence of functional PHEX leads to abnormal accumulation of ASARM (acidic serine- and aspartate-rich motif) peptide − a substrate for PHEX and a strong inhibitor of mineralization − derived from MEPE (matrix extracellular phosphoglycoprotein) and other matrix proteins. MEPE-derived ASARM peptide accumulates in tooth dentin of XLH patients where it may impair dentinogenesis. Here, we investigated the effects of ASARM peptides in vitro and in vivo on odontoblast differentiation and matrix mineralization. Dental pulp stem cells from human exfoliated deciduous teeth (SHEDs) were seeded into a 3D collagen scaffold, and induced towards odontogenic differentiation. Cultures were treated with synthetic ASARM peptides (phosphorylated and nonphosphorylated) derived from the human MEPE sequence. Phosphorylated ASARM peptide inhibited SHED differentiation in vitro, with no mineralized nodule formation, decreased odontoblast marker expression, and upregulated MEPE expression. Phosphorylated ASARM peptide implanted in a rat molar pulp injury model impaired reparative dentin formation and mineralization, with increased MEPE immunohistochemical staining. In conclusion, using complementary models to study tooth dentin defects observed in XLH, we demonstrate that the MEPE-derived ASARM peptide inhibits both odontogenic differentiation and matrix mineralization, while increasing MEPE expression. These results contribute to a partial mechanistic explanation of XLH pathogenesis: direct inhibition of mineralization by ASARM peptide leads to the mineralization defects in XLH teeth. This process appears to be positively reinforced by the increased MEPE expression induced by ASARM. The MEPE-ASARM system can therefore be considered as a potential therapeutic target.
58 citations
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TL;DR: A simple and cost effective technique for obtaining highly stable carbon coated nickel nanostructures at relatively low reaction temperatures is reported in this paper, where the powder X-ray diffraction pattern reveals peaks corresponding to face centered cubic nickel.
58 citations
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TL;DR: Laroscopic Heller myotomy favorably compares with open surgery regarding dysphagia relief and gastroesophageal reflux rate and overall clinical score indicates gradual improvement in patient functional status during 12-month follow-up.
58 citations
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TL;DR: This paper studies the hybrid synchronization between two identical hyperchaotic Lu systems through synchronization of two pairs of states and anti-synchronization of the other two pair of states.
Abstract: In this paper, we study the hybrid synchronization between two identical hyperchaotic Lu systems. Hybrid synchronization of hyperchaotic Lu system is achieved through synchronization of two pairs of states and anti-synchronization of the other two pairs of states. Active controls are designed to achieve hybrid synchronization between drive and response systems using the sum and difference of relevant variables of the chaotic systems. Numerical simulations are presented to evaluate the analysis and effectiveness of the controllers.
58 citations
Authors
Showing all 5433 results
Name | H-index | Papers | Citations |
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Pulickel M. Ajayan | 176 | 1223 | 136241 |
Maxime Dougados | 134 | 1054 | 69979 |
Sabu Thomas | 102 | 1554 | 51366 |
Philippe Ravaud | 101 | 618 | 41409 |
David P. Salmon | 99 | 419 | 43935 |
Jérôme Bertherat | 85 | 438 | 24794 |
Luc Mouthon | 84 | 564 | 26238 |
Xavier Bertagna | 74 | 285 | 18738 |
Alfred Mahr | 73 | 229 | 22581 |
Nicolas Roche | 72 | 629 | 22845 |
Charles Chapron | 71 | 378 | 18048 |
Benoit Terris | 61 | 234 | 13353 |
François Goffinet | 60 | 532 | 14433 |
Xavier Puéchal | 60 | 316 | 13240 |
Pascal Laugier | 58 | 482 | 10518 |