Showing papers by "Collège de France published in 2014"

Light-induced gauge fields for ultracold atoms

Abstract: Gauge fields are central in our modern understanding of physics at all scales. At the highest energy scales known, the microscopic universe is governed by particles interacting with each other through the exchange of gauge bosons. At the largest length scales, our Universe is ruled by gravity, whose gauge structure suggests the existence of a particle—the graviton—that mediates the gravitational force. At the mesoscopic scale, solid-state systems are subjected to gauge fields of different nature: materials can be immersed in external electromagnetic fields, but they can also feature emerging gauge fields in their low-energy description. In this review, we focus on another kind of gauge field: those engineered in systems of ultracold neutral atoms. In these setups, atoms are suitably coupled to laser fields that generate effective gauge potentials in their description. Neutral atoms ‘feeling’ laser-induced gauge potentials can potentially mimic the behavior of an electron gas subjected to a magnetic field, but also, the interaction of elementary particles with non-Abelian gauge fields. Here, we review different realized and proposed techniques for creating gauge potentials—both Abelian and non-Abelian—in atomic systems and discuss their implication in the context of quantum simulation. While most of these setups concern the realization of background and classical gauge potentials, we conclude with more exotic proposals where these synthetic fields might be made dynamical, in view of simulating interacting gauge theories with cold atoms.

The role of LiO2 solubility in O2 reduction in aprotic solvents and its consequences for Li-O2 batteries.

Abstract: The mechanism of O2 reduction in aprotic solvents is important for the operation of Li–O2 batteries but is not well understood. A single unified mechanism is now described that regards previous models as limiting cases. It shows that the solubility of the intermediate LiO2 is a critical factor that dictates the mechanism, emphasizing the importance of the solvent.

Periodically-driven quantum systems: Effective Hamiltonians and engineered gauge fields

Abstract: Topological effects can result from a material's intrinsic properties, or can be generated by external electromagnetic fields or mechanical deformations. Researchers analyze how driven quantum systems can lead to new topological states of matter.

Nonlinear lattice dynamics as a basis for enhanced superconductivity in YBa2Cu3O6.5.

Abstract: Femtosecond X-ray diffraction and ab initio density functional theory calculations are used to determine the crystal structure of YBa2Cu3O6.5 undergoing optically driven, nonlinear lattice excitation above the transition temperature of 52 kelvin, under which conditions the electronic structure of the material changes in such a way as to favour superconductivity. Andrea Cavalleri and colleagues use femtosecond X-ray diffraction measurements and ab initio density functional theory calculations to determine the crystal structure of YBa2Cu3O6+x undergoing optically driven, nonlinear lattice excitation at 100 kelvin. In this exotic non-equilibrium state, the electronic structure of the material changes in such a way as to favour superconductivity. The results reveal that in the driven state the superconducting planes are displaced closer and away from one another in a staggered manner, explaining how superconducting coupling can be enhanced or reduced, inside and between the bilayers. Terahertz-frequency optical pulses can resonantly drive selected vibrational modes in solids and deform their crystal structures1,2,3. In complex oxides, this method has been used to melt electronic order4,5,6, drive insulator-to-metal transitions7 and induce superconductivity8. Strikingly, coherent interlayer transport strongly reminiscent of superconductivity can be transiently induced up to room temperature (300 kelvin) in YBa2Cu3O6+x (refs 9, 10). Here we report the crystal structure of this exotic non-equilibrium state, determined by femtosecond X-ray diffraction and ab initio density functional theory calculations. We find that nonlinear lattice excitation in normal-state YBa2Cu3O6+x at above the transition temperature of 52 kelvin causes a simultaneous increase and decrease in the Cu–O2 intra-bilayer and, respectively, inter-bilayer distances, accompanied by anisotropic changes in the in-plane O–Cu–O bond buckling. Density functional theory calculations indicate that these motions cause drastic changes in the electronic structure. Among these, the enhancement in the character of the in-plane electronic structure is likely to favour superconductivity.

Whole-mantle radially anisotropic shear velocity structure from spectral-element waveform tomography

Abstract: S U M M A R Y The radially anisotropic shear velocity structure of the Earth’s mantle provides a critical window on the interior dynamics of the planet, with isotropic variations that are interpreted in terms of thermal and compositional heterogeneity and anisotropy in terms of flow. While significant progress has been made in the more than 30 yr since the advent of global seismic tomography, many open questions remain regarding the dual roles of temperature and composition in shaping mantle convection, as well as interactions between different dominant scales of convective phenomena. We believe that advanced seismic imaging techniques, such as waveform inversion using accurate numerical simulations of the seismic wavefield, represent a clear path forwards towards addressing these open questions through application to whole-mantle imaging. To this end, we employ a ‘hybrid’ waveform-inversion approach, which combines the accuracy and generality of the spectral finite element method (SEM) for forward modelling of the global wavefield, with non-linear asymptotic coupling theory for efficient inverse modelling. The resulting whole-mantle model (SEMUCB-WM1) builds on the earlier successful application of these techniques for global modelling at upper mantle and transition-zone depths (≤800 km) which delivered the models SEMum and SEMum2. Indeed, SEMUCB-WM1 is the first whole-mantle model derived from fully numerical SEM-based forward modelling. Here, we detail the technical aspects of the development of our wholemantle model, as well as provide a broad discussion of isotropic and radially anisotropic model structure. We also include an extensive discussion of model uncertainties, specifically focused on assessing our results at transition-zone and lower-mantle depths.

A Modified γ-Retrovirus Vector for X-Linked Severe Combined Immunodeficiency

Abstract: BACKGROUND In previous clinical trials involving children with X-linked severe combined immunodeficiency (SCID-X1), a Moloney murine leukemia virus–based γ-retrovirus vector expressing interleukin-2 receptor γ-chain (γc) complementary DNA successfully restored immunity in most patients but resulted in vector-induced leukemia through enhancermediated mutagenesis in 25% of patients. We assessed the efficacy and safety of a self-inactivating retrovirus for the treatment of SCID-X1. METHODS We enrolled nine boys with SCID-X1 in parallel trials in Europe and the United States to evaluate treatment with a self-inactivating (SIN) γ-retrovirus vector containing deletions in viral enhancer sequences expressing γc (SIN-γc). RESULTS All patients received bone marrow–derived CD34+ cells transduced with the SIN-γc vector, without preparative conditioning. After 12.1 to 38.7 months of follow-up, eight of the nine children were still alive. One patient died from an overwhelming adenoviral infection before reconstitution with genetically modified T cells. Of the remaining eight patients, seven had recovery of peripheral-blood T cells that were functional and led to resolution of infections. The patients remained healthy thereafter. The kinetics of CD3+ T-cell recovery was not significantly different from that observed in previous trials. Assessment of insertion sites in peripheral blood from patients in the current trial as compared with those in previous trials revealed significantly less clustering of insertion sites within LMO2, MECOM, and other lymphoid proto-oncogenes in our patients. CONCLUSIONS This modified γ-retrovirus vector was found to retain efficacy in the treatment of SCID-X1. The long-term effect of this therapy on leukemogenesis remains unknown. (Funded by the National Institutes of Health and others; ClinicalTrials.gov numbers, NCT01410019, NCT01175239, and NCT01129544.)

Final results of Borexino Phase-I on low-energy solar neutrino spectroscopy

Abstract: Borexino has been running since May 2007 at the Laboratori Nazionali del Gran Sasso laboratory in Italy with the primary goal of detecting solar neutrinos. The detector, a large, unsegmented liquid scintillator calorimeter characterized by unprecedented low levels of intrinsic radioactivity, is optimized for the study of the lower energy part of the spectrum. During Phase-I (2007–2010), Borexino first detected and then precisely measured the flux of the Be 7 solar neutrinos, ruled out any significant day-night asymmetry of their interaction rate, made the first direct observation of the pep neutrinos, and set the tightest upper limit on the flux of solar neutrinos produced in the CNO cycle (carbon, nitrogen, oxigen) where carbon, nitrogen, and oxygen serve as catalysts in the fusion process. In this paper we discuss the signal signature and provide a comprehensive description of the backgrounds, quantify their event rates, describe the methods for their identification, selection, or subtraction, and describe data analysis. Key features are an extensive in situ calibration program using radioactive sources, the detailed modeling of the detector response, the ability to define an innermost fiducial volume with extremely low background via software cuts, and the excellent pulse-shape discrimination capability of the scintillator that allows particle identification. We report a measurement of the annual modulation of the Be 7 neutrino interaction rate. The period, the amplitude, and the phase of the observed modulation are consistent with the solar origin of these events, and the absence of their annual modulation is rejected with higher than 99% C.L. The physics implications of Phase-I results in the context of the neutrino oscillation physics and solar models are presented.

Cerebellum involvement in cortical sensorimotor circuits for the control of voluntary movements

Abstract: Sensorimotor integration is crucial to perception and motor control. How and where this process takes place in the brain is still largely unknown. Here we analyze the cerebellar contribution to sensorimotor integration in the whisker system of mice. We identify an area in the cerebellum where cortical sensory and motor inputs converge at the cellular level. Optogenetic stimulation of this area affects thalamic and motor cortex activity, alters parameters of ongoing movements and thereby modifies qualitatively and quantitatively touch events against surrounding objects. These results shed light on the cerebellum as an active component of sensorimotor circuits and show the importance of sensorimotor cortico-cerebellar loops in the fine control of voluntary movements.

Theory of nonlinear phononics for coherent light control of solids

Abstract: A microscopic theory for ultrafast control of solids with tera-hertz optical pulses account for a light-induced insulator-to-metal transition.

Quench-induced supercurrents in an annular Bose gas.

Abstract: We create supercurrents in annular two-dimensional Bose gases through a temperature quench of the normal-to-superfluid phase transition We detect the magnitude and the direction of these supercurrents by measuring spiral patterns resulting from the interference of the cloud with a central reference disk These measurements demonstrate the stochastic nature of the supercurrents We further measure their distribution for different quench times and compare it with predictions based on the Kibble-Zurek mechanism

Partial differential equation models in macroeconomics.

Abstract: The purpose of this article is to get mathematicians interested in studying a number of partial differential equations (PDEs) that naturally arise in macroeconomics These PDEs come from models designed to study some of the most important questions in economics At the same time, they are highly interesting for mathematicians because their structure is often quite difficult We present a number of examples of such PDEs, discuss what is known about their properties, and list some open questions for future research

Crystal structures of a pentameric ligand-gated ion channel provide a mechanism for activation

Abstract: Pentameric ligand-gated ion channels mediate fast chemical transmission of nerve signals. The structure of a bacterial proton-gated homolog has been established in its open and locally closed conformations at acidic pH. Here we report its crystal structure at neutral pH, thereby providing the X-ray structures of the two end-points of the gating mechanism in the same pentameric ligand-gated ion channel. The large structural variability in the neutral pH structure observed in the four copies of the pentamer present in the asymmetric unit has been used to analyze the intrinsic fluctuations in this state, which are found to prefigure the transition to the open state. In the extracellular domain (ECD), a marked quaternary change is observed, involving both a twist and a blooming motion, and the pore in the transmembrane domain (TMD) is closed by an upper bend of helix M2 (as in locally closed form) and a kink of helix M1, both helices no longer interacting across adjacent subunits. On the tertiary level, detachment of inner and outer β sheets in the ECD reshapes two essential cavities at the ECD–ECD and ECD–TMD interfaces. The first one is the ligand-binding cavity; the other is close to a known divalent cation binding site in other pentameric ligand-gated ion channels. In addition, a different crystal form reveals that the locally closed and open conformations coexist as discrete ones at acidic pH. These structural results, together with site-directed mutagenesis, physiological recordings, and coarse-grained modeling, have been integrated to propose a model of the gating transition pathway.

Hybrid materials science: a promised land for the integrative design of multifunctional materials.

Abstract: For more than 5000 years, organic–inorganic composite materials created by men via skill and serendipity have been part of human culture and customs. The concept of “hybrid organic–inorganic” nanocomposites exploded in the second half of the 20th century with the expansion of the so-called “chimie douce” which led to many collaborations between a large set of chemists, physicists and biologists. Consequently, the scientific melting pot of these very different scientific communities created a new pluridisciplinary school of thought. Today, the tremendous effort of basic research performed in the last twenty years allows tailor-made multifunctional hybrid materials with perfect control over composition, structure and shape. Some of these hybrid materials have already entered the industrial market. Many tailor-made multiscale hybrids are increasingly impacting numerous fields of applications: optics, catalysis, energy, environment, nanomedicine, etc. In the present feature article, we emphasize several fundamental and applied aspects of the hybrid materials field: bioreplication, mesostructured thin films, Lego-like chemistry designed hybrid nanocomposites, and advanced hybrid materials for energy. Finally, a few commercial applications of hybrid materials will be presented.

Molecular Engineering of Functional Inorganic and Hybrid Materials

Abstract: For 25 years, Chemistry of Materials has been clearly providing a key forum to chemists, physicists, and engineers interested in materials preparation and characterization, in the search of unique physical properties and processing of innovative materials and devices. This short review presents a discussion on some recent advances in this field, illustrated with a few selected examples related to three of our main research areas: the synthesis of single nano-objects and the processing of porous and hierarchically structured materials and hybrid nanocomposite materials. A strong emphasis is also given to the need to realize a successful marriage between materials chemistry and smart processing. These cross-cutting approaches in the vein of bioinspired synthesis strategies are allowing the development of complex systems of various shapes with perfect mastery at different length scales of composition, structure, porosity, functionality, and morphology. These “integrative strategies”, where all aspects of mat...

Comparative analysis of Klebsiella pneumoniae genomes identifies a phospholipase D family protein as a novel virulence factor

Abstract: Klebsiella pneumoniae strains are pathogenic to animals and humans, in which they are both a frequent cause of nosocomial infections and a re-emerging cause of severe community-acquired infections. K. pneumoniae isolates of the capsular serotype K2 are among the most virulent. In order to identify novel putative virulence factors that may account for the severity of K2 infections, the genome sequence of the K2 reference strain Kp52.145 was determined and compared to two K1 and K2 strains of low virulence and to the reference strains MGH 78578 and NTUH-K2044. In addition to diverse functions related to host colonization and virulence encoded in genomic regions common to the four strains, four genomic islands specific for Kp52.145 were identified. These regions encoded genes for the synthesis of colibactin toxin, a putative cytotoxin outer membrane protein, secretion systems, nucleases and eukaryotic-like proteins. In addition, an insertion within a type VI secretion system locus included sel1 domain containing proteins and a phospholipase D family protein (PLD1). The pld1 mutant was avirulent in a pneumonia model in mouse. The pld1 mRNA was expressed in vivo and the pld1 gene was associated with K. pneumoniae isolates from severe infections. Analysis of lipid composition of a defective E. coli strain complemented with pld1 suggests an involvement of PLD1 in cardiolipin metabolism. Determination of the complete genome of the K2 reference strain identified several genomic islands comprising putative elements of pathogenicity. The role of PLD1 in pathogenesis was demonstrated for the first time and suggests that lipid metabolism is a novel virulence mechanism of K. pneumoniae.

Sulfate-Based Polyanionic Compounds for Li-Ion Batteries: Synthesis, Crystal Chemistry, and Electrochemistry Aspects

Abstract: Electrochemical storage has become an integral part of our mobile society and great hopes are being placed in Li-ion batteries to meet future demands dictated by the upcoming electric vehicle (EV) ...

Why Is There Philosophy of Mathematics At All

Abstract: Mathematics plays an inordinate role in the work of many of famous Western philosophers, from the time of Plato, through Husserl and Wittgenstein, and even to the present. Why? This paper points to the experience of learning or making mathematics, with an emphasis on proof. It distinguishes two sources of the perennial impact of mathematics on philosophy. They are classified as Ancient and Enlightenment. Plato is emblematic of the former, and Kant of the latter. The Ancient fascination arises from the sense that mathematics explores something ‘out there’. This is illustrated by recent discussions by distinguished contemporary mathematicians. The Enlightenment strand often uses Kant's argot: ‘absolute necessity’, ‘apodictic certainty’ and ‘a priori’ judgement or knowledge. The experience of being compelled by proof, the sense that something must be true, that a result is certain, generates the philosophy. It also creates the illusion that mathematics is certain. Kant's leading question, ‘How is pure mathematics possible?’, is easily misunderstood because the modern distinction between pure and applied is an artefact of the 19th century. As Russell put it, the issue is to explain ‘the apparent power of anticipating facts about things of which we have no experience’. More generally the question is, how is it that pure mathematics is so rich in applications? Some six types of application are distinguished, each of which engenders its own philosophical problems which are descendants of the Enlightenment, and which differ from those descended from the Ancient strand. Keywords: philosophy of mathematics, Plato, Kant, necessity, a priori, application.

Inversion of receiver functions without deconvolution—application to the Indian craton

Abstract: S U M M A R Y Receiver functions are a powerful tool to isolate and interpret receiver-side structure effects in teleseismic seismic records. They are easily constructed by deconvolving one component of a seismogram by another. Deconvolution is the inverse of convolution, and hence can be mathematically viewed as an inverse problem. It is a numerically unstable procedure that needs to be stabilized (i.e. regularized). This points to a recurring problem in geophysical imaging: there is a trade-off between variance and resolution, where the user needs to arbitrarily define a level of compromise. Here we propose a novel misfit function for inversion of converted phases that avoids deconvolution. In this way, the choice of regularization parameters (e.g. water level, width of a low pass filter) is avoided, and statistics of data errors can be correctly accounted for. We use this misfit measure to construct a likelihood probability function and carry out a transdimensional Bayesian inversion for shear wave structure. After illustrating the method with a synthetic test, a real data application is shown where teleseismic signals recorded at HYB station (Hyderabad, India) and surface wave dispersion measurements are jointly inverted to provide a probabilistic 1-D seismic model beneath the station. The results help address the debate on the thickness of the lithosphere in this region. We show that the sharp negative velocity jump at 110 km that was previously interpreted as the lithosphere– asthenosphere boundary (LAB) is actually a mid-lithospheric discontinuity. The actual LAB is seen deeper as a milder gradient between 150 and 200 km.

Mutation update: the spectra of nebulin variants and associated myopathies.

Abstract: A mutation update on the nebulin gene (NEB) is necessary because of recent developments in analysis methodology, the identification of increasing numbers and novel types of variants, and a widening in the spectrum of clinical and histological phenotypes associated with this gigantic, 183 exons containing gene. Recessive pathogenic variants in NEB are the major cause of nemaline myopathy (NM), one of the most common congenital myopathies. Moreover, pathogenic NEB variants have been identified in core-rod myopathy and in distal myopathies. In this update, we present the disease-causing variants in NEB in 159 families, 143 families with NM, and 16 families with NM-related myopathies. Eighty-eight families are presented here for the first time. We summarize 86 previously published and 126 unpublished variants identified in NEB. Furthermore, we have analyzed the NEB variants deposited in the Exome Variant Server (http://evs.gs.washington.edu/EVS/), identifying that pathogenic variants are a minor fraction of all coding variants (∼7%). This indicates that nebulin tolerates substantial changes in its amino acid sequence, providing an explanation as to why variants in such a large gene result in relatively rare disorders. Lastly, we discuss the difficulties of drawing reliable genotype-phenotype correlations in NEB-associated disease.

BIN1/M-Amphiphysin2 induces clustering of phosphoinositides to recruit its downstream partner dynamin

Abstract: Phosphoinositides play a central role in many physiological processes by assisting the recruitment of proteins to membranes through specific phosphoinositide-binding motifs. How this recruitment is coordinated in space and time is not well understood. Here we show that BIN1/M-Amphiphysin2, a protein involved in T-tubule biogenesis in muscle cells and frequently mutated in centronuclear myopathies, clusters PtdIns(4,5)P2 to recruit its downstream partner dynamin. By using several mutants associated with centronuclear myopathies, we find that the N-BAR and the SH3 domains of BIN1 control the kinetics and the accumulation of dynamin on membranes, respectively. We show that phosphoinositide clustering is a mechanism shared by other proteins that interact with PtdIns(4,5)P2, but do not contain a BAR domain. Our numerical simulations point out that clustering is a diffusion-driven process in which phosphoinositide molecules are not sequestered. We propose that this mechanism plays a key role in the recruitment of downstream phosphoinositide-binding proteins.

Determination of collagen fibril size via absolute measurements of second-harmonic generation signals

Abstract: The quantification of collagen fibril size is a major issue for the investigation of pathological disorders associated with structural defects of the extracellular matrix. Second-harmonic generation microscopy is a powerful technique to characterize the macromolecular organization of collagen in unstained biological tissues. Nevertheless, due to the complex coherent building of this nonlinear optical signal, it has never been used to measure fibril diameter so far. Here we report absolute measurements of second-harmonic signals from isolated fibrils down to 30 nm diameter, via implementation of correlative second-harmonic-electron microscopy. Moreover, using analytical and numerical calculations, we demonstrate that the high sensitivity of this technique originates from the parallel alignment of collagen triple helices within fibrils and the subsequent constructive interferences of second-harmonic radiations. Finally, we use these absolute measurements as a calibration for ex vivo quantification of fibril diameter in the Descemet's membrane of a diabetic rat cornea.

Cell death: a program to regenerate.

Abstract: Recent studies in Drosophila, Hydra, planarians, zebrafish, mice, indicate that cell death can open paths to regeneration in adult animals. Indeed injury can induce cell death, itself triggering regeneration following an immediate instructive mechanism, whereby the dying cells release signals that induce cellular responses over short and/or long-range distances. Cell death can also provoke a sustained derepressing response through the elimination of cells that suppress regeneration in homeostatic conditions. Whether common properties support what we name "regenerative cell death," is currently unclear. As key parameters, we review here the injury proapoptotic signals, the signals released by the dying cells, the cellular responses, and their respective timing. ROS appears as a common signal triggering cell death through MAPK and/or JNK pathway activation. But the modes of ROS production vary, from a brief pulse upon wounding, to repeated waves as observed in the zebrafish fin where ROS supports two peaks of cell death. Indeed regenerative cell death can be restricted to the injury phase, as in Hydra, Drosophila, or biphasic, immediate, and delayed, as in planarians and zebrafish. The dying cells release in a caspase-dependent manner a variety of signaling molecules, cytokines, growth factors, but also prostaglandins or ATP as recorded in Drosophila, Hydra, mice, and zebrafish, respectively. Interestingly, the ROS-producing cells often resist to cell death, implying a complex paracrine mode of signaling to launch regeneration, involving ROS-producing cells, ROS-sensing cells that release signaling molecules upon caspase activation, and effector cells that respond to these signals by proliferating, migrating, and/or differentiating.

Long coherence times for Rydberg qubits on a superconducting atom chip

Abstract: The quantum properties of cold rubidium atoms on a chip can be protected by a thin metal layer on the chip's surface.