Collège de France

About: Collège de France is a education organization based out in Paris, France. It is known for research contribution in the topics: Population & Dopamine. The organization has 6541 authors who have published 11983 publications receiving 648742 citations. The organization is also known as: College de France.

An Optimality Principle Governing Human Walking

Abstract: In this paper, we investigate different possible strategies underlying the formation of human locomotor trajectories in goal-directed walking. Seven subjects were asked to walk within a motion capture facility from a fixed starting point and direction, and to cross over distant porches for which both position and direction in the room were changed over trials. Stereotyped trajectories were observed in the different subjects. The underlying idea to attack this question has been to relate this problem to an optimal control scheme: the trajectory is chosen according to some optimization principle. This is our basic starting assumption. The subject being viewed as a controlled system, we tried to identify several criteria that could be optimized. Is it the time to perform the trajectory? The length of the path? The minimum jerk along the path? We found that the variation (time derivative) of the curvature of the locomotor paths is minimized. Moreover, we show that the human locomotor trajectories are well approximated by the geodesics of a differential system minimizing the norm of the control. Such geodesics are made of arcs of clothoids. The clothoid or Cornu spiral is a curve, whose curvature grows with the distance from the origin.

RXR gamma null mice are apparently normal and compound RXR alpha +/-/RXR beta -/-/RXR gamma -/- mutant mice are viable

Abstract: The RXR gamma (RXR, retinoid X receptor) gene was disrupted in the mouse. Homozygous mutant mice developed normally and were indistinguishable from their RXR gamma +/- or wild-type littermates with respect to growth, fertility, viability, and apparent behavior in the animal facility. Moreover, RXR alpha -/-/RXR gamma -/- and RXR beta -/-/RXR gamma -/- mutant phenotypes were indistinguishable from those of RXR alpha -/- and RXR beta -/- mutants, respectively. Strikingly, RXR alpha +/-/RXR beta -/-/RXR gamma -/- triple mutants were viable. Thus, it appears that RXR gamma does not exert any essential function that cannot be performed by RXR alpha or RXR beta, and one copy of RXR alpha is sufficient to perform most of the functions of the RXRs.

Viscous drops rolling on a tilted non-wettable solid

Abstract: A viscous liquid drop sliding down an inclined solid that it partially wets runs all the faster since it is large. Here we examine what happens in the limit of very high contact angles, on a so-called super-hydrophobic surface. It is shown that a droplet rolls instead of sliding, which leads to a surprising law for the velocity as a function of the drop radius: the smaller the droplet, the larger the running velocity. A recent model of Mahadevan and Pomeau allows us to propose an explanation for this paradoxical behaviour.

The Warburg effect is genetically determined in inherited pheochromocytomas.

Abstract: The Warburg effect describes how cancer cells down-regulate their aerobic respiration and preferentially use glycolysis to generate energy. To evaluate the link between hypoxia and Warburg effect, we studied mitochondrial electron transport, angiogenesis and glycolysis in pheochromocytomas induced by germ-line mutations in VHL, RET, NF1 and SDH genes. SDH and VHL gene mutations have been shown to lead to the activation of hypoxic response, even in normoxic conditions, a process now referred to as pseudohypoxia. We observed a decrease in electron transport protein expression and activity, associated with increased angiogenesis in SDH- and VHL-related, pseudohypoxic tumors, while stimulation of glycolysis was solely observed in VHL tumors. Moreover, microarray analyses revealed that expression of genes involved in these metabolic pathways is an efficient tool for classification of pheochromocytomas in accordance with the predisposition gene mutated. Our data suggest an unexpected association between pseudohypoxia and loss of p53, which leads to a distinct Warburg effect in VHL-related pheochromocytomas.