Institution
Collège de France
Education•Paris, France•
About: Collège de France is a education organization based out in Paris, France. It is known for research contribution in the topics: Population & Dopamine. The organization has 6541 authors who have published 11983 publications receiving 648742 citations. The organization is also known as: College de France.
Topics: Population, Dopamine, Dopaminergic, Receptor, Neural crest
Papers published on a yearly basis
Papers
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TL;DR: In this paper, the roles of 7 amino acids of the rat AT1A receptor in ligand binding and signaling were investigated by performing functional assays of individual receptor mutants expressed in COS and Chinese hamster ovary cells.
218 citations
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218 citations
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TL;DR: In this article, the role played by surface-anchored polymer layers in adhesion and friction is discussed, and the degree of interdigitation between the surface layer and the bulk polymer system is analyzed to determine the optimum enhancement in the adhesion energy between the solid wall and an elastomer.
Abstract: Polymer surfaces and interfaces have many technological applications. In the present article we review some recent experiments conducted on model systems with the aim of understanding the role played by surface-anchored polymer layers in adhesion and friction. We also discuss some of the related theoretical models. The key parameter for both situations is the degree of interdigitation between the surface layer and the bulk polymer system (an elastomer in the case of adhesion, a molten polymer in the case of friction). We analyze how this degree of interdigitation governs the optimum enhancement in the adhesion energy between the solid wall and an elastomer, and how it is at the origin of the various wall slip regimes observed experimentally.
217 citations
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TL;DR: It is shown that Hoxa2 induction at postmigratory stages results in mirror image homeotic transformation of a subset of jaw elements, normally devoid of Hox expression, towards hyoid morphology, and this demonstrates that the skeletal pattern of rhombomeric mandibular crest is not committed before migration.
Abstract: Hox genes are required to pattern neural crest (NC) derived craniofacial and visceral skeletal structures. However, the temporal requirement of Hox patterning activity is not known. Here, we use an inducible system to establish Hoxa2 activity at distinct NC migratory stages in Xenopus embryos. We uncover stage-specific effects of Hoxa2 gain-of-function suggesting a multistep patterning process for hindbrain NC. Most interestingly, we show that Hoxa2 induction at postmigratory stages results in mirror image homeotic transformation of a subset of jaw elements, normally devoid of Hox expression, towards hyoid morphology. This is the reverse phenotype to that observed in the Hoxa2 knockout. These data demonstrate that the skeletal pattern of rhombomeric mandibular crest is not committed before migration and further implicate Hoxa2 as a true selector of hyoid fate. Moreover, the demonstration that the expression of Hoxa2 alone is sufficient to transform the upper jaw and its joint selectively may have implications for the evolution of jaws.
216 citations
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TL;DR: This study is the first to demonstrate the presence of all components of the RAS in very early human development (30-35 days of gestation) and likely plays a role in the growth and differentiation of the kidney, adrenal gland, heart, and liver, all organs that are of major importance for the regulation of blood pressure later in life.
Abstract: Increasing evidence suggests that the renin-angiotensin system (RAS) is not only a potent regulator of blood pressure and fluid and electrolyte homeostasis, but that it also plays an important role in growth and differentiation in development as well as in pathological states. We, therefore, investigated the expression of all components of the RAS in the human embryo and fetus by in situ hybridization or immunohistochemistry. This study is the first to demonstrate the presence of all components of the RAS in very early human development (30-35 days of gestation). Angiotensinogen mRNA is expressed in very high amounts in the yolk sac, liver, and kidney, whereas renin mRNA and angiotensin-converting enzyme are expressed in the chorion, kidney, and heart, thus allowing fetal production of angiotensin II. This effector molecule of the RAS mediates its effects through binding to specific receptor types, AT1 and AT2. Both of these receptors are also expressed very early in development (24 days of gestation), suggesting a role for angiotensin II in organogenesis. Based on the expression pattern of these receptors, angiotensin II likely plays a role in the growth and differentiation of the kidney, adrenal gland, heart, and liver, all organs that are of major importance for the regulation of blood pressure later in life.
216 citations
Authors
Showing all 6597 results
Name | H-index | Papers | Citations |
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Pierre Chambon | 211 | 884 | 161565 |
Irving L. Weissman | 201 | 1141 | 172504 |
David R. Williams | 178 | 2034 | 138789 |
Kari Alitalo | 174 | 817 | 114231 |
Pierre Bourdieu | 153 | 592 | 194586 |
Stanislas Dehaene | 149 | 456 | 86539 |
Howard L. Weiner | 144 | 1047 | 91424 |
Alain Fischer | 143 | 770 | 81680 |
Yves Agid | 141 | 669 | 74441 |
Michel Foucault | 140 | 499 | 191296 |
Jean-Pierre Changeux | 138 | 672 | 76462 |
Jean-Marie Tarascon | 136 | 853 | 137673 |
K. Ganga | 132 | 272 | 99004 |
Jacques Delabrouille | 131 | 354 | 94923 |
G. Patanchon | 128 | 241 | 87233 |