Institution
Collège de France
Education•Paris, France•
About: Collège de France is a education organization based out in Paris, France. It is known for research contribution in the topics: Population & Dopamine. The organization has 6541 authors who have published 11983 publications receiving 648742 citations. The organization is also known as: College de France.
Topics: Population, Dopamine, Dopaminergic, Receptor, Neural crest
Papers published on a yearly basis
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TL;DR: Light is shed on the cerebellum as an active component of sensorimotor circuits and the importance of sensorsimotor cortico-cerebellar loops in the fine control of voluntary movements is shown.
Abstract: Sensorimotor integration is crucial to perception and motor control. How and where this process takes place in the brain is still largely unknown. Here we analyze the cerebellar contribution to sensorimotor integration in the whisker system of mice. We identify an area in the cerebellum where cortical sensory and motor inputs converge at the cellular level. Optogenetic stimulation of this area affects thalamic and motor cortex activity, alters parameters of ongoing movements and thereby modifies qualitatively and quantitatively touch events against surrounding objects. These results shed light on the cerebellum as an active component of sensorimotor circuits and show the importance of sensorimotor cortico-cerebellar loops in the fine control of voluntary movements.
209 citations
TL;DR: The results suggest that BMP-2 is part of the complex of cardiogenic signals and is involved in the patterning of early mesoderm similar to the role of dpp in Drosophila.
209 citations
TL;DR: The most recent X-ray structures of bacterial and invertebrate pentameric receptors point to a striking conservation of the structural features within the whole family, even between distant prokaryotic and eukaryotic members.
209 citations
TL;DR: Research dealing with gap junctions in the nervous system has expanded enormously in the past decade, major findings being that specific cell types in the brain expresses specific types of connexins and that expression patterns coincide with tissue compartmentalization and function and that these compartments change during development.
208 citations
TL;DR: These findings provided evidence of frequent (37%) loss-of-function mutations in DEPDC5 associated with a broad spectrum of focal epilepsies and the implication of a DEP domain–containing protein that may be involved in membrane trafficking and/or G protein signaling opens new avenues for research.
Abstract: The main familial focal epilepsies are autosomal dominant nocturnal frontal lobe epilepsy, familial temporal lobe epilepsy and familial focal epilepsy with variable foci. A frameshift mutation in the DEPDC5 gene (encoding DEP domain-containing protein 5) was identified in a family with focal epilepsy with variable foci by linkage analysis and exome sequencing. Subsequent pyrosequencing of DEPDC5 in a cohort of 15 additional families with focal epilepsies identified 4 nonsense mutations and 1 missense mutation. Our findings provided evidence of frequent (37%) loss-of-function mutations in DEPDC5 associated with a broad spectrum of focal epilepsies. The implication of a DEP (Dishevelled, Egl-10 and Pleckstrin) domain-containing protein that may be involved in membrane trafficking and/or G protein signaling opens new avenues for research.
208 citations
Authors
Showing all 6597 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Pierre Chambon | 211 | 884 | 161565 |
| Irving L. Weissman | 201 | 1141 | 172504 |
| David R. Williams | 178 | 2034 | 138789 |
| Kari Alitalo | 174 | 817 | 114231 |
| Pierre Bourdieu | 153 | 592 | 194586 |
| Stanislas Dehaene | 149 | 456 | 86539 |
| Howard L. Weiner | 144 | 1047 | 91424 |
| Alain Fischer | 143 | 770 | 81680 |
| Yves Agid | 141 | 669 | 74441 |
| Michel Foucault | 140 | 499 | 191296 |
| Jean-Pierre Changeux | 138 | 672 | 76462 |
| Jean-Marie Tarascon | 136 | 853 | 137673 |
| K. Ganga | 132 | 272 | 99004 |
| Jacques Delabrouille | 131 | 354 | 94923 |
| G. Patanchon | 128 | 241 | 87233 |