Institution
Collège de France
Education•Paris, France•
About: Collège de France is a education organization based out in Paris, France. It is known for research contribution in the topics: Population & Dopamine. The organization has 6541 authors who have published 11983 publications receiving 648742 citations. The organization is also known as: College de France.
Topics: Population, Dopamine, Dopaminergic, Receptor, Neural crest
Papers published on a yearly basis
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188 citations
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TL;DR: Data show that SHH is able to activate myogenesis in vivo and in vitro in already committed myoblasts and suggest that the stimulation of the myogenic programme by SHH involves activation of cell proliferation.
Abstract: Myogenic Regulatory Factors (MRFs) are a family of transcription factors whose expression in a cell reflects the commitment of this cell to a myogenic fate before any cytological sign of muscle differentiation is detectable. Myogenic cells in limb skeletal muscles originate from the lateral half of the somites. Cells that migrate away from the lateral part of the somites to the limb bud do not initially express any member of the MRF family. Expression of MRFs in the muscle precursor cells starts after the migration process is completed. The extracellular signals involved in activating the myogenic programme in muscle precursor cells in the limb in vivo are not known. We wished to investigate whether Sonic Hedgehog (SHH) expressed in the posterior part of the limb bud could be involved in differentiation of the muscle precursor cells in the limb. We found that retrovirally overexpressed SHH in the limb bud induced the extension of the expression domain of the Pax-3 gene, then that of the MyoD gene and finally that of the myosin protein. This led to an hypertrophy of the muscles in vivo. Addition of SHH to primary cultures of myoblasts resulted in an increase in the proportion of myoblasts that incorporate bromodeoxyuridine, resulting in an increase of myotube number. These data show that SHH is able to activate myogenesis in vivo and in vitro in already committed myoblasts and suggest that the stimulation of the myogenic programme by SHH involves activation of cell proliferation.
188 citations
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University of Bern1, ETH Zurich2, Complutense University of Madrid3, University of Barcelona4, University of Almería5, University of Zaragoza6, University of Vigo7, Pablo de Olavide University8, Rovira i Virgili University9, University of Bonn10, Alfred Wegener Institute for Polar and Marine Research11, University of Bremen12, Augsburg College13, University of Würzburg14, Centre national de la recherche scientifique15, Çanakkale Onsekiz Mart University16, University of Lisbon17, University of Sunderland18, Met Office19, Pennsylvania State University20, University of Arizona21, Columbia University22, National Research Council23, ENEA24, University of Milan25, National and Kapodistrian University of Athens26, University of Padua27, University of Évora28, RWTH Aachen University29, St. Francis Xavier University30, University of Caen Lower Normandy31, Collège de France32
TL;DR: In this paper, a necessary task for assessing to which degree the industrial period is unusual against the background of pre-industrial climate variability is discussed, which is the reconstruction and interpretation of temporal and spatial patterns of climate in earlier centuries.
Abstract: Publisher Summary This chapter discusses a necessary task for assessing to which degree the industrial period is unusual against the background of pre-industrial climate variability. It is the reconstruction and interpretation of temporal and spatial patterns of climate in earlier centuries. There are distinct differences in the temporal resolution among the various proxies. Some of the proxy records are annually or even higher resolved and hence record year-by-year patterns of climate in past centuries. Several of the temperature reconstructions reveal that the late twentieth century warmth is unprecedented at hemispheric scales and is explained by anthropogenic, greenhouse gas (GHG) forcing. The chapter discusses the availability and potential of long, homogenized instrumental data, documentary, and natural proxies to reconstruct aspects of past climate at local- to regional-scales within the larger Mediterranean area, which includes climate extremes and the incidence of natural disasters. The chapter describes the role of external forcing, including natural and anthropogenic influences, and natural, internal variability in the coupled ocean–atmosphere system at subcontinental scale.
188 citations
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TL;DR: The characterized FMRP binding site (FBS) within the FMR1 mRNA is characterized by a site directed mutagenesis approach and it is shown that the FBS is a potent exonic splicing enhancer in a minigene system.
Abstract: The fragile X mental retardation protein (FMRP) is a RNA-binding protein proposed to post-transcriptionally regulate the expression of genes important for neuronal development and synaptic plasticity. We previously demonstrated that FMRP binds to its own FMR1 mRNA via a guanine-quartet (G-quartet) RNA motif. However, the functional effect of this binding on FMR1 expression was not established. In this work, we characterized the FMRP binding site (FBS) within the FMR1 mRNA by a site directed mutagenesis approach and we investigated its importance for FMR1 expression. We show that the FBS in the FMR1 mRNA adopts two alternative G-quartet structures to which FMRP can equally bind. While FMRP binding to mRNAs is generally proposed to induce translational regulation, we found that mutations in the FMR1 mRNA suppressing binding to FMRP do not affect its translation in cellular models. We show instead that the FBS is a potent exonic splicing enhancer in a minigene system. Furthermore, FMR1 alternative splicing is affected by the intracellular level of FMRP. These data suggest that the G-quartet motif present in the FMR1 mRNA can act as a control element of its alternative splicing in a negative autoregulatory loop.
188 citations
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TL;DR: The provocative finding that not only do differentiating pancreatic endocrine cells synthesize a neuronal marker, tyrosine hydroxylase (TH), but that developing neurons in the neural tube transcribe the insulin gene is reported.
188 citations
Authors
Showing all 6597 results
Name | H-index | Papers | Citations |
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Pierre Chambon | 211 | 884 | 161565 |
Irving L. Weissman | 201 | 1141 | 172504 |
David R. Williams | 178 | 2034 | 138789 |
Kari Alitalo | 174 | 817 | 114231 |
Pierre Bourdieu | 153 | 592 | 194586 |
Stanislas Dehaene | 149 | 456 | 86539 |
Howard L. Weiner | 144 | 1047 | 91424 |
Alain Fischer | 143 | 770 | 81680 |
Yves Agid | 141 | 669 | 74441 |
Michel Foucault | 140 | 499 | 191296 |
Jean-Pierre Changeux | 138 | 672 | 76462 |
Jean-Marie Tarascon | 136 | 853 | 137673 |
K. Ganga | 132 | 272 | 99004 |
Jacques Delabrouille | 131 | 354 | 94923 |
G. Patanchon | 128 | 241 | 87233 |