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Institution

Collège de France

EducationParis, France
About: Collège de France is a education organization based out in Paris, France. It is known for research contribution in the topics: Population & Dopamine. The organization has 6541 authors who have published 11983 publications receiving 648742 citations. The organization is also known as: College de France.


Papers
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Journal ArticleDOI
TL;DR: Current knowledge of the 3D organization of the mammalian X-chromosome chromatin is reviewed and its relationship with gene activity in light of the initiation, spreading, and maintenance of XCI, as well as escape from gene silencing is discussed.
Abstract: In somatic nuclei of female therian mammals, the two X chromosomes display very different chromatin states: One X is typically euchromatic and transcriptionally active, and the other is mostly sile...

170 citations

Journal ArticleDOI
TL;DR: The results suggest that the biological role of PARP-1 andPARP-2 within the nucleolus relies on functional nucleolar transcription, without any obvious implication of either PARP on this major nucleolar process.
Abstract: The DNA damage-dependent poly(ADP-ribose) polymerases-1 and -2 (PARP-1 and PARP-2) are survival factors that share overlapping functions in the detection, signaling and repair of DNA strand breaks resulting from genotoxic lesions in mammalian cells. Here we show that PARP-1 and PARP-2 subnuclear distributions partially overlap, with both proteins accumulating within the nucleolus independently of each other. PARP-2 is enriched within the whole nucleolus and partially colocalizes with the nucleolar factor nucleophosmin/B23. We have identified a nuclear localization signal and a nucleolar localization signal within the N-terminal domain of PARP-2. PARP-2, like PARP-1, interacts with B23 through its N-terminal DNA binding domain. This association is constitutive and does not depend on either PARP activity or ribosomal transcription, but is prevented by mutation of the nucleolar localization signal of PARP-2. PARP-1 and PARP-2, together with B23, are delocalized from the nucleolus upon RNA polymerase I inhibition whereas the nucleolar accumulation of all three proteins is only moderately affected upon oxidative or alkylated DNA damage. Finally, we show that murine fibroblasts deficient in PARP-1 or PARP-2 are not affected in the transcription of ribosomal RNAs. Taken together, these results suggest that the biological role of PARP-1 and PARP-2 within the nucleolus relies on functional nucleolar transcription, without any obvious implication of either PARP on this major nucleolar process.

170 citations

Journal ArticleDOI
TL;DR: Some experiments are reported which show that CyAMP does, under proper conditions, antagonize the repression of enzyme synthesis by glucose.

170 citations


Authors

Showing all 6597 results

NameH-indexPapersCitations
Pierre Chambon211884161565
Irving L. Weissman2011141172504
David R. Williams1782034138789
Kari Alitalo174817114231
Pierre Bourdieu153592194586
Stanislas Dehaene14945686539
Howard L. Weiner144104791424
Alain Fischer14377081680
Yves Agid14166974441
Michel Foucault140499191296
Jean-Pierre Changeux13867276462
Jean-Marie Tarascon136853137673
K. Ganga13227299004
Jacques Delabrouille13135494923
G. Patanchon12824187233
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
20238
202293
2021418
2020429
2019385
2018391