Collège de France

About: Collège de France is a education organization based out in Paris, France. It is known for research contribution in the topics: Population & Receptor. The organization has 6541 authors who have published 11983 publications receiving 648742 citations. The organization is also known as: College de France.

Why race still matters

Abstract: Daedalus Winter 2005 Why has race mattered in so many times and places? Why does it still matter? Put more precisely, why has there been such a pervasive tendency to apply the category of race and to regard people of different races as essentially different kinds of people? Call this the ‘1⁄2rst question.’ Of course there are many more questions that one must also ask: Why has racial oppression been so ubiquitous? Why racial exploitation? Why racial slavery? Perhaps we tend to think of races as essentially different just because we want to excuse or to justify the domination of one race by another. I shall proceed with the 1⁄2rst question by canvassing 1⁄2ve possible answers to it that variously invoke nature, genealogy (in the sense of Michel Foucault), cognitive science, empire, and pollution rules. One 1⁄2nal preliminary remark is in order. Most parts of this essay could have been written last year or next year, but the discussion of naturalism, medicine, and race could only have been written in November of 2004, and may well be out of date by the time this piece is printed.

Mapping of a First Locus for Autosomal Dominant Myxomatous Mitral-Valve Prolapse to Chromosome 16p11.2-p12.1

Abstract: Myxomatous mitral-valve prolapse (MMVP), also called Barlow disease, is a common cardiac abnormality and affects up to 5% of the population. It is characterized by an excess of tissue that leads to billowing of the mitral leaflets, sometimes complicated by prolapse. Typical histological findings include myxomatous degeneration and degradation of collagen and elastin. Previous reports have proposed an autosomal dominant inheritance of the trait, with age- and sex-dependent expression. By systematic echocardiographic screening of the first-degree relatives of 17 patients who underwent mitral-valve repair, we have identified four pedigrees showing such an inheritance. Genomewide linkage analysis of the most informative pedigree (24 individuals, three generations) showed a significant linkage for markers mapping to chromosome 16p, with a two-point maximum LOD score for D16S3068 (Zmax=3.30 at straight theta=0). Linkage to D16S3068 was confirmed in a second family (Zmax=2.02 at straight theta=0) but was excluded for the two remaining families, thus demonstrating the genetic heterogeneity of the disease. Multipoint linkage analysis performed, with nine additional markers, on the two families with linkage gave maximum multipoint LOD scores of 5.45 and 5.68 for D16S3133, according to a conservative and a stringent model, respectively. Haplotype analysis defined a 5-cM minimal MMVP-1 locus between D16S3068 (16p11.2) and D16S420 (16p12. 1) and a 34-cM maximal interval between D16S404 and D16S3068 when recombination events were taken into account only in affected individuals. The identification of this locus represents a first step toward a new molecular classification of mitral-valve prolapse.

The First IBIS/ISGRI Soft Gamma-Ray Galactic Plane Survey Catalog*

Abstract: We report the first high-energy survey catalog obtained with the IBIS gamma-ray imager on board INTEGRAL. The analysis has been performed on the first-year Core Program ISGRI data comprising both Galactic Plane Scan and Galactic Centre Deep Exposure pointings for a total exposure time exceeding 5 Ms. This initial survey has revealed the presence of ~120 sources detected with the unprecedented sensitivity of ~1 mcrab in the energy range 20-100 keV. Each source is located to an accuracy between 1' and 3', depending on its brightness. The outstanding IBIS capability to locate soft γ-ray emitters has allowed us to identify most of the detected sources with already known Galactic X-ray binary systems, while 28 of the objects are of unknown nature.