Institution
Collège de France
Education•Paris, France•
About: Collège de France is a education organization based out in Paris, France. It is known for research contribution in the topics: Population & Dopamine. The organization has 6541 authors who have published 11983 publications receiving 648742 citations. The organization is also known as: College de France.
Topics: Population, Dopamine, Dopaminergic, Receptor, Neural crest
Papers published on a yearly basis
Papers
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TL;DR: TIF2 exhibited the characteristics expected for a bona fide NR coactivator, in both mammalian and yeast cells, and a peptide encompassing the TIF2 NID inhibited the ligand‐induced AF‐2 activity of several NRs, indicating that NR AF‐ 2 activity is either mediated by endogenous Tif2 or by coactivators recognizing a similar surface on NR holo‐LBDs.
Abstract: The nuclear receptor (NR) coactivator TIF2 possesses a single NR interaction domain (NID) and two autonomous activation domains, AD1 and AD2. The TIF2 NID is composed of three NR-interacting modules each containing the NR box motif LxxLL. Mutation of boxes I, II and III abrogates TIF2-NR interaction and stimulation, in transfected cells, of the ligand-induced activation function-2 (AF-2) present in the ligand-binding domains (LBDs) of several NRs. The presence of an intact NR interaction module II in the NID is sufficient for both efficient interaction with NR holo-LBDs and stimulation of AF-2 activity. Modules I and III are poorly efficient on their own, but synergistically can promote interaction with NR holo-LBDs and AF-2 stimulation. TIF2 AD1 activity appears to be mediated through CBP, as AD1 could not be separated mutationally from the CBP interaction domain. In contrast, TIF2 AD2 activity apparently does not involve interaction with CBP. TIF2 exhibited the characteristics expected for a bona fide NR coactivator, in both mammalian and yeast cells. Moreover, in mammalian cells, a peptide encompassing the TIF2 NID inhibited the ligand-induced AF-2 activity of several NRs, indicating that NR AF-2 activity is either mediated by endogenous TIF2 or by coactivators recognizing a similar surface on NR holo-LBDs.
517 citations
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TL;DR: In this paper, the authors review different phenomenological descriptions of rough wetting and show how these classical laws must be modified on rough solids, and introduce the questions of hemi-wicking (can a film propagate inside the texture of a solid), rough films, and super-hydrophobicity (how can a solid be designed to become water repellent).
Abstract: After a brief presentation of the classical laws of wetting, we review different phenomenological descriptions of rough wetting, i.e., show how these classical laws must be modified on rough solids. This introduces the questions of hemi-wicking (can a film propagate inside the texture of a solid ?), rough films (is it possible for a liquid film to follow the roughness of a solid ?) and super-hydrophobicity (how can a solid be designed to become water repellent ?).
517 citations
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TL;DR: In this article, a long-baseline reactor-neutrino vacuum-oscillation experiment (CHOOZ 1 ) was presented, where the neutrino detector was constructed in a tunnel protected from cosmic rays by a 300 MWE rock overburden.
516 citations
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TL;DR: This work directly test the hypothesis that transformations of mental images are at least in part guided by motor processes by means of a dual-task paradigm in which subjects perform the Cooper-Shepard mental rotation task while executing an unseen motor rotation in a given direction and at a previously-learned speed.
514 citations
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30 Jan 2001-Comptes Rendus De L Academie Des Sciences Serie Ii Fascicule A-sciences De La Terre Et Des Planetes
TL;DR: The remains of an early hominid have been recovered from four localities in the Lukeino Formation, Tugen Hills, Kenya, in sediments aged ca 6-Ma as discussed by the authors.
Abstract: Remains of an early hominid have been recovered from four localities in the Lukeino Formation, Tugen Hills, Kenya, in sediments aged ca 6 Ma. 13 fossils are known, belonging to at least five individuals. The femora indicate that the Lukeino hominid was a biped when on the ground, whilst its humerus and manual phalanx show that it possessed some arboreal adaptations. The upper central incisor is large and robust, the upper canine is large for a hominid and retains a narrow and shallow anterior groove, the lower fourth premolar is ape-like, with offset roots and oblique crown, and the molars are relatively small, with thick enamel. A new genus and species is erected for the remains.
510 citations
Authors
Showing all 6597 results
Name | H-index | Papers | Citations |
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Pierre Chambon | 211 | 884 | 161565 |
Irving L. Weissman | 201 | 1141 | 172504 |
David R. Williams | 178 | 2034 | 138789 |
Kari Alitalo | 174 | 817 | 114231 |
Pierre Bourdieu | 153 | 592 | 194586 |
Stanislas Dehaene | 149 | 456 | 86539 |
Howard L. Weiner | 144 | 1047 | 91424 |
Alain Fischer | 143 | 770 | 81680 |
Yves Agid | 141 | 669 | 74441 |
Michel Foucault | 140 | 499 | 191296 |
Jean-Pierre Changeux | 138 | 672 | 76462 |
Jean-Marie Tarascon | 136 | 853 | 137673 |
K. Ganga | 132 | 272 | 99004 |
Jacques Delabrouille | 131 | 354 | 94923 |
G. Patanchon | 128 | 241 | 87233 |