Institution
Collège de France
Education•Paris, France•
About: Collège de France is a education organization based out in Paris, France. It is known for research contribution in the topics: Population & Receptor. The organization has 6541 authors who have published 11983 publications receiving 648742 citations. The organization is also known as: College de France.
Topics: Population, Receptor, Dopamine, Dopaminergic, Neural crest
Papers published on a yearly basis
Papers
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TL;DR: Evidence is provided that HES1 regulates differentiation of retinal neurons and is essential for eye morphogenesis.
338 citations
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TL;DR: In this paper, extended double shuffle (EDS) relations for multiple zeta values (MZVs) are derived and derived algebraic structures of MZVs, as well as a linearized version of EDS relations are also studied.
Abstract: Derivation and extended double shuffle (EDS) relations for multiple zeta values (MZVs) are proved. Related algebraic structures of MZVs, as well as a ‘linearized’ version of EDS relations are also studied.
336 citations
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Harvard University1, Great Ormond Street Hospital for Children NHS Foundation Trust2, Boston Children's Hospital3, University of California, San Diego4, Necker-Enfants Malades Hospital5, Cincinnati Children's Hospital Medical Center6, French Institute of Health and Medical Research7, University College London8, Pasteur Institute9, University of Pennsylvania10, Hannover Medical School11, University of California, Los Angeles12, Collège de France13
TL;DR: This modified γ-retrovirus vector was found to retain efficacy in the treatment of SCID-X1 and the long-term effect of this therapy on leukemogenesis remains unknown.
Abstract: BACKGROUND In previous clinical trials involving children with X-linked severe combined immunodeficiency (SCID-X1), a Moloney murine leukemia virus–based γ-retrovirus vector expressing interleukin-2 receptor γ-chain (γc) complementary DNA successfully restored immunity in most patients but resulted in vector-induced leukemia through enhancermediated mutagenesis in 25% of patients. We assessed the efficacy and safety of a self-inactivating retrovirus for the treatment of SCID-X1. METHODS We enrolled nine boys with SCID-X1 in parallel trials in Europe and the United States to evaluate treatment with a self-inactivating (SIN) γ-retrovirus vector containing deletions in viral enhancer sequences expressing γc (SIN-γc). RESULTS All patients received bone marrow–derived CD34+ cells transduced with the SIN-γc vector, without preparative conditioning. After 12.1 to 38.7 months of follow-up, eight of the nine children were still alive. One patient died from an overwhelming adenoviral infection before reconstitution with genetically modified T cells. Of the remaining eight patients, seven had recovery of peripheral-blood T cells that were functional and led to resolution of infections. The patients remained healthy thereafter. The kinetics of CD3+ T-cell recovery was not significantly different from that observed in previous trials. Assessment of insertion sites in peripheral blood from patients in the current trial as compared with those in previous trials revealed significantly less clustering of insertion sites within LMO2, MECOM, and other lymphoid proto-oncogenes in our patients. CONCLUSIONS This modified γ-retrovirus vector was found to retain efficacy in the treatment of SCID-X1. The long-term effect of this therapy on leukemogenesis remains unknown. (Funded by the National Institutes of Health and others; ClinicalTrials.gov numbers, NCT01410019, NCT01175239, and NCT01129544.)
336 citations
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TL;DR: In this paper, the adsorption of polymer chains on small objects in solution, such as micelles, is discussed using scaling results to describe the confinement energy, and appropriate power laws for the dimensions and energies are derived.
Abstract: The adsorption of polymer chains on small objects in solution, such as micelles, is discussed using scaling results to describe the confinement energy. Adsorption on small spheres and on clusters of such spheres is discussed and appropriate power laws for the dimensions and energies are derived. For non-interacting objects the segregation of a dense, gel-like phase, is predicted. The direct relevance to solutions which can form micelles is also discussed briefly.
335 citations
Authors
Showing all 6597 results
Name | H-index | Papers | Citations |
---|---|---|---|
Pierre Chambon | 211 | 884 | 161565 |
Irving L. Weissman | 201 | 1141 | 172504 |
David R. Williams | 178 | 2034 | 138789 |
Kari Alitalo | 174 | 817 | 114231 |
Pierre Bourdieu | 153 | 592 | 194586 |
Stanislas Dehaene | 149 | 456 | 86539 |
Howard L. Weiner | 144 | 1047 | 91424 |
Alain Fischer | 143 | 770 | 81680 |
Yves Agid | 141 | 669 | 74441 |
Michel Foucault | 140 | 499 | 191296 |
Jean-Pierre Changeux | 138 | 672 | 76462 |
Jean-Marie Tarascon | 136 | 853 | 137673 |
K. Ganga | 132 | 272 | 99004 |
Jacques Delabrouille | 131 | 354 | 94923 |
G. Patanchon | 128 | 241 | 87233 |