Collège de France

About: Collège de France is a education organization based out in Paris, France. It is known for research contribution in the topics: Population & Receptor. The organization has 6541 authors who have published 11983 publications receiving 648742 citations. The organization is also known as: College de France.

Direct measurement of the Wigner function of a one-photon Fock state in a cavity.

Abstract: We have measured the complete Wigner function $W$ of the vacuum and of a single-photon state for a field stored in a high-$Q$ cavity. This experiment implements the direct Lutterbach and Davidovich method [L. G. Lutterbach and L. Davidovich, Phys. Rev. Lett. 78, 2547 (1997)] and is based on the dispersive interaction of a single circular Rydberg atom with the cavity field. The nonclassical nature of the single-photon field is exhibited by a region of negative $W$ values. Extensions to other nonclassical cavity field states are discussed.

Skin abnormalities generated by temporally controlled RXRα mutations in mouse epidermis

Abstract: Nuclear receptors for retinoids (RARs) and vitamin D (VDR), and for some other ligands (TRs, PPARs and LXRs), maybe critical in the development and homeostasis of mammalian epidermis. It is believed that these receptors form heterodimers with retinoid X receptors (RXRs) to act as transcriptional regulators. However, most genetic approaches aimed at establishing their physiological functions in the skin have been inconclusive owing either to pleiotropic effects and redundancies between receptor isotypes in gene knockouts, or to equivocal interpretation of dominant-negative mutant studies in transgenic mice. Moreover, knockout of RXRalpha, the main skin RXR isotype, is lethal in utero before skin formation. Here we have resolved these problems by developing an efficient technique to create spatiotemporally controlled somatic mutations in the mouse. We used tamoxifen-inducible Cre-ER(T) recombinases to ablate RXRalpha selectively in adult mouse keratinocytes. We show that RXRalpha has key roles in hair cycling, probably through RXR/VDR heterodimers, and in epidermal keratinocyte proliferation and differentiation.

NSD1 is essential for early post-implantation development and has a catalytically active SET domain

Abstract: The nuclear receptor-binding SET domain-containing protein (NSD1) belongs to an emerging family of proteins, which have all been implicated in human malignancy To gain insight into the biological functions of NSD1, we have generated NSD1-deficient mice by gene disruption Homozygous mutant NSD1 embryos, which initiate mesoderm formation, display a high incidence of apoptosis and fail to complete gastrulation, indicating that NSD1 is a developmental regulatory protein that exerts function(s) essential for early post-implantation development We have also examined the enzymatic potential of NSD1 and found that its SET domain possesses intrinsic histone methyltransferase activity with specificity for Lys36 of histone H3 (H3-K36) and Lys20 of histone H4 (H4-K20)

Cohomological Invariants in Galois Cohomology

Abstract: Cohomological invariants, Witt invariants, and trace forms: Contents by J.-P. Serre and S. Garibaldi Introduction by J.-P. Serre and S. Garibaldi The notion of "invariant" by J.-P. Serre and S. Garibaldi Cohomological preliminaries: The local case by J.-P. Serre and S. Garibaldi Cohomological preliminaries: The function field case by J.-P. Serre and S. Garibaldi Specialization properties of cohomological invariants by J.-P. Serre and S. Garibaldi Restriction and corestriction of invariants by J.-P. Serre and S. Garibaldi Cohomological invariants of $O_n,SO_n,\ldots$ by J.-P. Serre and S. Garibaldi Cohomological invariants of etale algebras by J.-P. Serre and S. Garibaldi Witt invariants by J.-P. Serre and S. Garibaldi The trace form in dimension $\le 7$ by J.-P. Serre and S. Garibaldi A letter from M. Rost to J-P. Serre by M. Rost A letter from J-P. Serre to R. S. Garibaldi by J.-P. Serre A letter from B. Totaro to J-P. Serre by B. Totaro Rost invariants of simply connected algebraic groups: Contents by A. Merkurjev and S. Garibaldi Rost invariants of simply connected algebraic groups by A. Merkurjev and S. Garibaldi The groups $H^{d+1}(F,\mathbb{Q}^mathbb{Z}(d))$ by A. Merkurjev and S. Garibaldi Tables of Dynkin indices by A. Merkurjev and S. Garibaldi Bibliography Index of notation Index of terms.