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Institution

Collège de France

EducationParis, France
About: Collège de France is a education organization based out in Paris, France. It is known for research contribution in the topics: Population & Dopamine. The organization has 6541 authors who have published 11983 publications receiving 648742 citations. The organization is also known as: College de France.


Papers
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Journal ArticleDOI
Felix Aharonian1, A. G. Akhperjanian1, Klaus-Michael Aye2, A. R. Bazer-Bachi3, M. Beilicke1, Wystan Benbow1, David Berge1, P. Berghaus4, Konrad Bernlöhr1, Catherine Boisson5, O. Bolz1, C. Borgmeier6, Ilana M. Braun1, F. Breitling6, A. M. Brown2, J. Bussons Gordo7, P. M. Chadwick2, L.-M. Chounet8, R. Cornils1, Luigi Costamante1, B. Degrange8, A. Djannati-Ataï4, L. O'c. Drury9, Guillaume Dubus1, Tulun Ergin6, P. Espigat4, F. Feinstein1, P. Fleury8, G. Fontaine8, Stefan Funk1, Y. A. Gallant1, B. Giebels8, Stefan Gillessen1, P. Goret10, C. Hadjichristidis2, M. Hauser, G. Heinzelmann11, Gilles Henri12, German Hermann1, Jim Hinton1, Werner Hofmann1, M. Holleran13, Dieter Horns1, O. C. de Jager13, I. Jung1, B. Khélifi1, Nu. Komin6, A. Konopelko1, I. J. Latham2, R. Le Gallou2, A. Lemière4, M. Lemoine8, N. Leroy8, Thomas Lohse6, A. Marcowith3, Conor Masterson1, T. J. L. McComb2, M. de Naurois1, S. J. Nolan2, A. Noutsos2, K. J. Orford1, J. L. Osborne1, M. Ouchrif5, M. Panter1, Guy Pelletier12, S. Pita4, G. Pühlhofer1, Michael Punch4, B. C. Raubenheimer13, M. Raue1, J. Raux5, S. M. Rayner2, I. Redondo8, A. Reimer14, Olaf Reimer14, J. Ripken11, L. Rob15, L. Rolland5, Gavin Rowell1, V. Sahakian16, L. Saugé1, S. Schlenker6, Reinhard Schlickeiser14, C. Schuster14, U. Schwanke6, M. Siewert14, Helene Sol5, R. Steenkamp17, C. Stegmann6, J.-P. Tavernet5, R. Terrier4, C. G. Théoret4, M. Tluczykont8, D. J. van der Walt13, G. Vasileiadis1, Christo Venter13, P. Vincent5, B. Visser13, Heinrich J. Völk1, Stefan Wagner 
25 Mar 2005-Science
TL;DR: A first sensitive survey of the inner part of the Milky Way with the High Energy Stereoscopic System (HESS) reveals a population of eight previously unknown firmly detected sources of very high energy γ-rays.
Abstract: Very high energy gamma-rays probe the long-standing mystery of the origin of cosmic rays. Produced in the interactions of accelerated particles in astrophysical objects, they can be used to image cosmic particle accelerators. A first sensitive survey of the inner part of the Milky Way with the High Energy Stereoscopic System (HESS) reveals a population of eight previously unknown firmly detected sources of very high energy gamma-rays. At least two have no known radio or x-ray counterpart and may be representative of a new class of "dark" nucleonic cosmic ray sources.

317 citations

Journal ArticleDOI
TL;DR: These guidelines provide consensus considerations and recommendations for diagnosis, assessment, staging, and treatment of primary CNS lymphoma and should aid clinicians in their daily practice and decision making, and serve as a basis for future investigations in neuro-oncology.
Abstract: The management of primary CNS lymphoma is one of the most controversial topics in neuro-oncology because of the complexity of the disease and the very few controlled studies available. In 2013, the European Association of Neuro-Oncology created a multidisciplinary task force to establish evidence-based guidelines for immunocompetent adults with primary CNS lymphoma. In this Review, we present these guidelines, which provide consensus considerations and recommendations for diagnosis, assessment, staging, and treatment of primary CNS lymphoma. Specifically, we address aspects of care related to surgery, systemic and intrathecal chemotherapy, intensive chemotherapy with autologous stem-cell transplantation, radiotherapy, intraocular manifestations, and management of elderly patients. The guidelines should aid clinicians in their daily practice and decision making, and serve as a basis for future investigations in neuro-oncology.

315 citations

Journal ArticleDOI
TL;DR: Results indicated that Mash1 and Math3 direct neuronal versus glial fate determination in the CNS and raised the possibility that downregulation of these bHLH genes is one of the mechanisms to initiate gliogenesis.
Abstract: Whereas vertebrate achaete–scute complex (as-c) and atonal (ato) homologs are required for neurogenesis, their neuronal determination activities in the central nervous system (CNS) are not yet supported by loss-of-function studies, probably because of genetic redundancy. Here, to address this problem, we generated mice double mutant for the as-c homolog Mash1 and the ato homolog Math3. Whereas in Mash1 or Math3 single mutants neurogenesis is only weakly affected, in the double mutants tectal neurons, two longitudinal columns of hindbrain neurons and retinal bipolar cells were missing and, instead, those cells that normally differentiate into neurons adopted the glial fate. These results indicated that Mash1 and Math3 direct neuronal versus glial fate determination in the CNS and raised the possibility that downregulation of these bHLH genes is one of the mechanisms to initiate gliogenesis.

315 citations

Journal ArticleDOI
TL;DR: ANGPTL4, originally identified as a peroxisome proliferator-activated receptor alpha and gamma target gene, has potential for use as a new diagnostic tool and a potential therapeutic target, modulating angiogenesis both in tumors and in ischemic tissues.
Abstract: Ischemic and solid tumor tissues are less well perfused than normal tissue, leading to metabolic changes and chronic hypoxia, which in turn promotes angiogenesis. We identified human angiopoietin-like 4 (angptl4) as a gene with hypoxia-induced expression in endothelial cells. We showed that the levels of both mRNA and protein for ANGPTL4 increased in response to hypoxia. When tested in the chicken chorioallantoic membrane assay, ANGPTL4 induced a strong proangiogenic response, independently of vascular endothelial growth factor. In human pathology, ANGPTL4 mRNA is produced in ischemic tissues, in conditions such as critical leg ischemia. In tumors, ANGPTL4 is produced in the hypoxic areas surrounding necrotic regions. We observed particularly high levels of ANGPTL4 mRNA in tumor cells of conventional renal cell carcinoma. Other benign and malignant renal tumor cells do not produce ANGPTL4 mRNA. This molecule therefore seems to be a marker of conventional renal cell carcinoma. ANGPTL4, originally identified as a peroxisome proliferator-activated receptor α and γ target gene, has potential for use as a new diagnostic tool and a potential therapeutic target, modulating angiogenesis both in tumors and in ischemic tissues. This study also suggests that ANGPTL4 may provide a link between metabolic disorders and hypoxia-induced angiogenesis.

315 citations

Journal ArticleDOI
TL;DR: The selective expression of RXR beta in Sertoli cells, together with the timing of appearance of the histological abnormalities, suggests that the primary defect resulting from the mutation resides in these cells.
Abstract: We have generated mouse lines in which the RXR beta gene was disrupted by homologous recombination. Approximately 50% of the RXR beta homozygous mutants died before or at birth, but those that survived appeared normal except that the males were sterile, owing to oligo-astheno-teratozoospermia. Failure of spermatid release occurred within the germinal epithelium, and the epididymis contained very few spermatozoa that, in addition, exhibited abnormal acrosomes and tails. There was a progressive accumulation of lipids within the mutant Sertoli cells, which were histochemically characterized as unsaturated triglycerides. In old mutant males, progressive degeneration of the germinal epithelium occurred, ending with the formation of acellular lipid-filled tubules. The selective expression of RXR beta in Sertoli cells, together with the timing of appearance of the histological abnormalities, suggests that the primary defect resulting from the mutation resides in these cells.

314 citations


Authors

Showing all 6597 results

NameH-indexPapersCitations
Pierre Chambon211884161565
Irving L. Weissman2011141172504
David R. Williams1782034138789
Kari Alitalo174817114231
Pierre Bourdieu153592194586
Stanislas Dehaene14945686539
Howard L. Weiner144104791424
Alain Fischer14377081680
Yves Agid14166974441
Michel Foucault140499191296
Jean-Pierre Changeux13867276462
Jean-Marie Tarascon136853137673
K. Ganga13227299004
Jacques Delabrouille13135494923
G. Patanchon12824187233
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
20238
202293
2021418
2020429
2019385
2018391