Institution
Collège de France
Education•Paris, France•
About: Collège de France is a education organization based out in Paris, France. It is known for research contribution in the topics: Population & Dopamine. The organization has 6541 authors who have published 11983 publications receiving 648742 citations. The organization is also known as: College de France.
Topics: Population, Dopamine, Dopaminergic, Receptor, Neural crest
Papers published on a yearly basis
Papers
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TL;DR: Two genes causing pseudohypoaldosteronism type II, a Mendelian trait featuring hypertension, increased renal salt reabsorption, and impaired K+ and H+ excretion are identified.
Abstract: Hypertension is a major public health problem of largely unknown cause. Here, we identify two genes causing pseudohypoaldosteronism type II, a Mendelian trait featuring hypertension, increased renal salt reabsorption, and impaired K+ and H+ excretion. Both genes encode members of the WNK family of serine-threonine kinases. Disease-causing mutations in WNK1 are large intronic deletions that increase WNK1 expression. The mutations in WNK4 are missense, which cluster in a short, highly conserved segment of the encoded protein. Both proteins localize to the distal nephron, a kidney segment involved in salt, K+, and pH homeostasis. WNK1 is cytoplasmic, whereas WNK4 localizes to tight junctions. The WNK kinases and their associated signaling pathway(s) may offer new targets for the development of antihypertensive drugs.
1,363 citations
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TL;DR: In this paper, a scaling description of the chain configurations and interactions is used, and it is shown that the presence of a uniform surface attraction changes the phase diagram drastically, and the transition between the two phases is first order.
Abstract: The adsorption of chain molecules at an interface is investigated assuming that the molecule has both a polar head type of attraction localized on the chain and a uniform interaction of the chain monomers with the surface. A scaling description of the chain configurations and interactions is used. It is shown that the presence of a uniform surface attraction changes the phase diagram drastically. Both a low density two-dimensional regime and a high density phase with the chains confined in narrow cylinders can occur. The transition between the two phases is first order. Power laws for the surface density, layer thickness and surface pressure are derived. The qualitative similarity with the behaviour observed for short chain lipids and surfactants is also noted and it is suggested that a uniform surface interaction may also play an important role there.
1,360 citations
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1,319 citations
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TL;DR: In this paper, the authors discuss quantitatively the wetting of a solid textured by a designed roughness, both hydrophilic and hydrophobic case, together with possible implications for the wading of porous materials.
1,299 citations
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30 Apr 1998TL;DR: In this paper, the evolution of the information seeking and use models for professionals, essentially, the information access practices, is discussed. But two main categories can be distinguished : the informationseeking and use model versus the information retrieval model, and we will evaluate them in order to see if a convergence is possible with the same vocabulary and procedures.
Abstract: This study concerns the evolution of the information seeking and use models for professionals essentially, the information access practices. Coming from Anglo-Saxon literature, this new information science research trend, evolve with paradigms and different information seeking and use models have emerged, in order to explain how professional seeks information and what can be done in order to help them. Two main categories can be distinguished : the information seeking and use model versus the information retrieval model. So we will present today this diversity of models and we will evaluate them in order to see if a convergence is possible with the same vocabulary and procedures.
1,294 citations
Authors
Showing all 6597 results
Name | H-index | Papers | Citations |
---|---|---|---|
Pierre Chambon | 211 | 884 | 161565 |
Irving L. Weissman | 201 | 1141 | 172504 |
David R. Williams | 178 | 2034 | 138789 |
Kari Alitalo | 174 | 817 | 114231 |
Pierre Bourdieu | 153 | 592 | 194586 |
Stanislas Dehaene | 149 | 456 | 86539 |
Howard L. Weiner | 144 | 1047 | 91424 |
Alain Fischer | 143 | 770 | 81680 |
Yves Agid | 141 | 669 | 74441 |
Michel Foucault | 140 | 499 | 191296 |
Jean-Pierre Changeux | 138 | 672 | 76462 |
Jean-Marie Tarascon | 136 | 853 | 137673 |
K. Ganga | 132 | 272 | 99004 |
Jacques Delabrouille | 131 | 354 | 94923 |
G. Patanchon | 128 | 241 | 87233 |