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Institution

Colorado State University

EducationFort Collins, Colorado, United States
About: Colorado State University is a education organization based out in Fort Collins, Colorado, United States. It is known for research contribution in the topics: Population & Radar. The organization has 31430 authors who have published 69040 publications receiving 2724463 citations. The organization is also known as: CSU & Colorado Agricultural College.
Topics: Population, Radar, Poison control, Laser, Soil water


Papers
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Book ChapterDOI
01 Jan 1998
TL;DR: Model building and data analysis in the biological sciences somewhat presupposes that the person has some advanced education in the quantitative sciences, and statistics in particular, and this requirement also implies that a person has substantial knowledge of statistical hypothesis-testing approaches.
Abstract: Model building and data analysis in the biological sciences somewhat presupposes that the person has some advanced education in the quantitative sciences, and statistics in particular This requirement also implies that a person has substantial knowledge of statistical hypothesis-testing approaches Such people, including ourselves over the past several years, often find it difficult to understand the information-theoretic approach, only because it is conceptually so very different from the testing approach that is so familiar Relatively speaking, the concepts and practical use of the information-theoretic approach are much simpler than those of statistical hypothesis testing, and very much simpler than some of the various Bayesian approaches to data analysis (eg, Laud and Ibrahim 1995 and Carlin and Chib 1995)

446 citations

Book
15 Nov 2012
TL;DR: Researchers developing large-scale inversion methods for linear or nonlinear inverse problems, as well as engineers working in research and development departments at high-tech companies and in electrical impedance tomography, will also find this a valuable guide.
Abstract: Inverse problems arise in practical applications whenever there is a need to interpret indirect measurements This book explains how to identify ill-posed inverse problems arising in practice and how to design computational solution methods for them; explains computational approaches in a hands-on fashion, with related codes available on a website; and serves as a convenient entry point to practical inversion The guiding linear inversion examples are the problem of image deblurring, x-ray tomography, and backward parabolic problems, including heat transfer, and electrical impedance tomography is used as the guiding nonlinear inversion example The book s nonlinear material combines the analytic-geometric research tradition and the regularization-based school of thought in a fruitful manner, paving the way to new theorems and algorithms for nonlinear inverse problems Furthermore, it is the only mathematical textbook with a thorough treatment of electrical impedance tomography, and these sections are suitable for beginning and experienced researchers in mathematics and engineering Audience: Linear and Nonlinear Inverse Problems with Practical Applications is well-suited for students in mathematics, engineering, physics, or computer science who wish to learn computational inversion (inverse problems) Professors will find that the exercises and project work topics make this a suitable textbook for advanced undergraduate and graduate courses on inverse problems Researchers developing large-scale inversion methods for linear or nonlinear inverse problems, as well as engineers working in research and development departments at high-tech companies and in electrical impedance tomography, will also find this a valuable guide Contents Part I: Linear Inverse Problems; Chapter 1: Introduction; Chapter 2: Nave Reconstructions and Inverse Crimes; Chapter 3: Ill-Posedness in Inverse Problems; Chapter 4: Truncated Singular Value Decomposition; Chapter 5: Tikhonov Regularization; Chapter 6: Total Variation Regularization; Chapter 7: Besov Space Regularization Using Wavelets; Chapter 8: Discretization-Invariance; Chapter 9: Practical X-ray Tomography with limited data; Chapter 10: Projects; Part II: Nonlinear Inverse Problems; Chapter 11: Nonlinear Inversion; Chapter 12: Electrical Impedance Tomography; Chapter 13: Simulation of Noisy EIT Data; Chapter 14: Complex Geometrical Optics Solutions; Chapter 15: A Regularized D-bar Method for Direct EIT; Chapter 16: Other Direct Solution Methods for EIT; Chapter 17: Projects; Appendix A: Banach Spaces and Hilbert Spaces; Appendix B: Mappings and Compact Operators; Appendix C: Fourier Transforms and Sobolev Spaces; Appendix D: Iterative Solution of Linear Equations

445 citations

Journal ArticleDOI
Ad Bax1
TL;DR: In this article, the authors proposed an approach to homonuclear broadband decoupling for semiselective heteronuclear J spectroscopy, where all protons which are not directly attached to a 13C nucleus experience an effect as if a nonselective 180" pulse were applied, while protons bonded to a r3C nucleus are not affected.

445 citations

Journal ArticleDOI
TL;DR: A review of the current knowledge of permeability barriers for and active efflux of drug molecules and potential strategies to overcome them suggests these mechanisms may be good targets for new drugs.

445 citations

Journal ArticleDOI
TL;DR: Results indicate that there are optimum levels of Ca2+ influx that promote normal neurite elongation and growth cone movements; these 2 components of outgrowth appear to have differential sensitivities to Ca2+.
Abstract: Neurite outgrowth from isolated, identified molluscan (Helisoma trivolvis) neurons in culture can be suppressed by neurotransmitters and electrical activity, both of which increase intraneuronal Ca2+ levels (Haydon et al., 1984; Cohan et al., 1986, 1987). We explored the possibility of a causal relationship between Ca2+ influx from the cell exterior and neurite outgrowth using a spectrum of pharmacological manipulations known to affect transmembrane Ca2+ flux. Ca2+ ionophore A23187, an agent expected to increase Ca2+ influx, suppressed both elongation and motile growth cone structures (i.e., filopodia and lamellipodia) in a dose-dependent (10(8)-10(6) M) and reversible manner. Furthermore, high concentrations of Ca2+ channel blockers (La3+, Cd2+, Co2+; e.g., 10(-4) M La3+) suppressed both elongation and growth cone movements. These data support previous experiments, which indicated that neurite outgrowth is dependent upon a specific range of intracellular Ca2+ concentrations (Connor, 1986; Cohan et al., 1987). However, tests of the dose-dependency of the effects of Ca2+ channel blockers on outgrowth revealed that specific, low concentrations of Ca2+ channel blockers (e.g., 10(-5) M La3+) caused, simultaneously, a reduction of growth cone filopodia and an acceleration of elongation. Consistent with the results using low levels of Ca2+ channel blockers, reduced extracellular Ca2+-stimulated neurite elongation while suppressing growth cone motility. Finally, neurotransmitter regulation of neurite outgrowth was shown to require influx of extracellular Ca2+; serotonin inhibition of neuron B19 was prevented by La3+ (10(-5) M) or by incubation in a reduced Ca2+ environment. Taken together, these results indicate that there are optimum levels of Ca2+ influx that promote normal neurite elongation and growth cone movements; these 2 components of outgrowth appear to have differential sensitivities to Ca2+.

442 citations


Authors

Showing all 31766 results

NameH-indexPapersCitations
Mark P. Mattson200980138033
Stephen J. O'Brien153106293025
Ad Bax13848697112
David Price138168793535
Georgios B. Giannakis137132173517
James Mueller134119487738
Christopher B. Field13340888930
Steven W. Running12635576265
Simon Lin12675469084
Jitender P. Dubey124134477275
Gregory P. Asner12361360547
Steven P. DenBaars118136660343
Peter Molnar11844653480
William R. Jacobs11849048638
C. Patrignani1171754110008
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023159
2022500
20213,596
20203,492
20193,340
20183,136