Colorado State University

About: Colorado State University is a education organization based out in Fort Collins, Colorado, United States. It is known for research contribution in the topics: Population & Radar. The organization has 31430 authors who have published 69040 publications receiving 2724463 citations. The organization is also known as: CSU & Colorado Agricultural College.

Enhanced dihydropyridine receptor channel activity in the presence of ryanodine receptor.

Abstract: EXCITATION-CONTRACTION coupling in skeletal muscle involves a voltage sensor in the plasma membrane which, in response to depolarization, causes an intracellular calcium-release channel to open. The skeletal isoform of the ryanodine receptor (RyR-1) functions as the Ca2+-release channel1–3 and the dihydropyridine receptor (DHPR) functions as the voltage sensor and also as an L-type Ca2+ channel4,5. Here we examine the possibility that there is a retrograde signal from RyR-1 to the DHPR, using myotubes from mice homozygous for a disrupted RyR-1 gene (dyspedic mice)3. As expected, we find that there is no excitation–contraction coupling in dyspedic myotubes, but we also find that they have a roughly 30-fold reduction in L-type Ca2+-current density. Injection of dyspedic myotubes with RyR-1 complementary DNA restores excitation–contraction coupling and causes the density of L-type Ca2+ current to rise towards normal. Despite the differences in Ca2+-current magnitude, measurements of charge movement indicate that the density of DHPRs is similar in dyspedic and RyR-1-expressing myotubes. Our results support the possibility of a retrograde signal by which RyR-1 enhances the function of DHPRs as Ca2+ channels.

A Coupling of Benzamides and Donor/Acceptor Diazo Compounds To Form γ-Lactams via Rh(III)-Catalyzed C–H Activation

Abstract: The coupling of O-pivaloyl benzhydroxamic acids with donor/acceptor diazo compounds provides isoindolones in high yield. The reaction tolerates a broad range of benzhydroxamic acids and diazo compounds, including substituted 2,2,2-trifluorodiazoethanes. Mechanistic experiments suggested that C–H activation is turnover-limiting and irreversible and that insertion of the diazo compound favors electron-deficient substrates.

A meteorological distribution system for high-resolution terrestrial modeling (MicroMet)

Abstract: An intermediate-complexity, quasi–physically based, meteorological model (MicroMet) has been developed to produce high-resolution (e.g., 30-m to 1-km horizontal grid increment) atmospheric forcings required to run spatially distributed terrestrial models over a wide variety of landscapes. The following eight variables, required to run most terrestrial models, are distributed: air temperature, relative humidity, wind speed, wind direction, incoming solar radiation, incoming longwave radiation, surface pressure, and precipitation. To produce these distributions, MicroMet assumes that at least one value of each of the following meteorological variables are available for each time step, somewhere within, or near, the simulation domain: air temperature, relative humidity, wind speed, wind direction, and precipitation. These variables are collected at most meteorological stations. For the incoming solar and longwave radiation, and surface pressure, either MicroMet can use its submodels to generate these fields, or it can create the distributions from observations as part of a data assimilation procedure. MicroMet includes a preprocessor component that analyzes meteorological data, then identifies and corrects potential deficiencies. Since providing temporally and spatially continuous atmospheric forcing data for terrestrial models is a core objective of MicroMet, the preprocessor also fills in any missing data segments with realistic values. Data filling is achieved by employing a variety of procedures, including an autoregressive integrated moving average calculation for diurnally varying variables (e.g., air temperature). To create the distributed atmospheric fields, spatial interpolations are performed using the Barnes objective analysis scheme, and subsequent corrections are made to the interpolated fields using known temperature–elevation, wind–topography, humidity–cloudiness, and radiation–cloud–topography relationships.

In situ detection of biological particles in cloud ice-crystals

Abstract: The impact of aerosol particles on the formation and properties of clouds is one of the largest remaining sources of uncertainty in climate change projections. Now, aircraft-aerosol time-of-flight spectroscopy measurements of ice residues indicate that biological particles trigger ice formation in high-altitude clouds.

Search for a dark photon in e(+)e(-) collisions at BABAR.

Abstract: Dark sectors charged under a new Abelian interaction have recently received much attention in the context of dark matter models. These models introduce a light new mediator, the so-called dark photon (A^{'}), connecting the dark sector to the standard model. We present a search for a dark photon in the reaction e^{+}e^{-}→γA^{'}, A^{'}→e^{+}e^{-}, μ^{+}μ^{-} using 514 fb^{-1} of data collected with the BABAR detector. We observe no statistically significant deviations from the standard model predictions, and we set 90% confidence level upper limits on the mixing strength between the photon and dark photon at the level of 10^{-4}-10^{-3} for dark photon masses in the range 0.02-10.2 GeV. We further constrain the range of the parameter space favored by interpretations of the discrepancy between the calculated and measured anomalous magnetic moment of the muon.