Colorado State University

About: Colorado State University is a education organization based out in Fort Collins, Colorado, United States. It is known for research contribution in the topics: Population & Radar. The organization has 31430 authors who have published 69040 publications receiving 2724463 citations. The organization is also known as: CSU & Colorado Agricultural College.

Operational estimates of reference evapotranspiration

Abstract: Many forms of the Penman combination equation have been proffered for estimating daily evapotranspiration (ET) by the agricultural reference crops grass and alfalfa (Medicago sativa L.). This study was conducted to evaluate popular forms of the Penman equation, and to develop and evaluate general relationships for estimating daily average values of canopy and aerodynamic resistance parameters required by the Penman-Monteith equation. For simplicity and ease of use, resistance relationships were expressed as linear and logarithmic functions of mean plant height. The Penman-Monteith and other forms of the Penman equation were compared at 11 international lysimeter sites, with the Penman-Monteith method and a Penman equation with variable wind function developed at Kimberly, ID providing the best estimates of reference ET across the sites. Ratios of computed alfalfa to grass reference ET during peak months at various locations averaged 1.32, and ranged from 1.12 to 1.43. Values of computed ratios were related to local wind and humidity conditions. The development of relationships for canopy and aerodynamic resistances as functions of reference crop height allowed use of the Penman-Monteith equation in an operational mode, and improved transferability of this resistance form of the Penman equation to a wide variety of climates.

Comparing entire colour patterns as birds see them

Abstract: Colour patterns and their visual backgrounds consist of a mosaic of patches that vary in colour, brightness, size, shape and position. Most studies of crypsis, aposematism, sexual selection, or other forms of signalling concentrate on one or two patch classes (colours), either ignoring the rest of the colour pattern, or analysing the patches separately. We summarize methods of comparing colour patterns making use of known properties of bird eyes. The methods are easily modifiable for other animal visual systems. We present a new statistical method to compare entire colour patterns rather than comparing multiple pairs of patches. Unlike previous methods, the new method detects differences in the relationships among the colours, not just differences in colours. We present tests of the method's ability to detect a variety of kinds of differences between natural colour patterns and provide suggestions for analysis.

Caspase 3-mediated stimulation of tumor cell repopulation during cancer radiotherapy

Abstract: In cancer treatment, apoptosis is a well-recognized cell death mechanism through which cytotoxic agents kill tumor cells. Here we report that dying tumor cells use the apoptotic process to generate potent growth-stimulating signals to stimulate the repopulation of tumors undergoing radiotherapy. Furthermore, activated caspase 3, a key executioner in apoptosis, is involved in the growth stimulation. One downstream effector that caspase 3 regulates is prostaglandin E(2) (PGE(2)), which can potently stimulate growth of surviving tumor cells. Deficiency of caspase 3 either in tumor cells or in tumor stroma caused substantial tumor sensitivity to radiotherapy in xenograft or mouse tumors. In human subjects with cancer, higher amounts of activated caspase 3 in tumor tissues are correlated with markedly increased rate of recurrence and death. We propose the existence of a cell death-induced tumor repopulation pathway in which caspase 3 has a major role.

Effects of exurban development on biodiversity: patterns, mechanisms, and research needs

Abstract: Low-density rural home development is the fastest-growing form of land use in the United States since 1950. This ''exurban'' development ( ;6-25 homes/km 2 ) includes urban fringe development (UFD) on the periphery of cities and rural residential development (RRD) in rural areas attractive in natural amenities. This paper synthesizes current knowl- edge on the effects of UFD and RRD. We present two case studies and examine the patterns of biodiversity response and the ecological mechanisms that may underlie these responses. We found that many native species have reduced survival and reproduction near homes, and native species richness often drops with increased exurban densities. Exotic species, some human-adapted native species, and species from early successional stages often in- crease with exurban development. These relationships are sometimes nonlinear, with sharp thresholds in biodiversity response. These effects may be manifest for several decades following exurban development, so that biodiversity is likely still responding to the wave of exurban expansion that has occurred since 1950. The location of exurban development is often nonrandom relative to biodiversity because both are influenced by biophysical factors. Consequently, the effects on biodiversity may be disproportionately large relative to the area of exurban development. RRD is more likely than UFD to occur near public lands; hence it may have a larger influence on nature reserves and wilderness species. The ecological mechanisms that may underlie these responses involve alteration of habitat, ecological processes, biotic interactions, and increased human disturbance. Research on the patterns and mechanisms of biodiversity remains underdeveloped, and comparative and experimental studies are needed. Knowledge resulting from such studies will increase our ability to understand, manage, and mitigate negative impacts on biodiversity.

Synergy in a medicinal plant: antimicrobial action of berberine potentiated by 5′-methoxyhydnocarpin, a multidrug pump inhibitor.

Abstract: Multidrug resistance pumps (MDRs) protect microbial cells from both synthetic and natural antimicrobials. Amphipathic cations are preferred substrates of MDRs. Berberine alkaloids, which are cationic antimicrobials produced by a variety of plants, are readily extruded by MDRs. Several Berberis medicinal plants producing berberine were found also to synthesize an inhibitor of the NorA MDR pump of a human pathogen Staphylococcus aureus. The inhibitor was identified as 5′-methoxyhydnocarpin (5′-MHC), previously reported as a minor component of chaulmoogra oil, a traditional therapy for leprosy. 5′-MHC is an amphipathic weak acid and is distinctly different from the cationic substrates of NorA. 5′-MHC had no antimicrobial activity alone but strongly potentiated the action of berberine and other NorA substrates against S. aureus. MDR-dependent efflux of ethidium bromide and berberine from S. aureus cells was completely inhibited by 5′-MHC. The level of accumulation of berberine in the cells was increased strongly in the presence of 5′-MHC, indicating that this plant compound effectively disabled the bacterial resistance mechanism against the berberine antimicrobial.