Concordia University

About: Concordia University is a education organization based out in Montreal, Quebec, Canada. It is known for research contribution in the topics: Control theory & Population. The organization has 13565 authors who have published 31084 publications receiving 783525 citations. The organization is also known as: Sir George Williams University & Loyola College, Montreal.

A Foundation for Multi-dimensional Databases

Abstract: We present a multi-dimensional database model, which we believe can serve as a conceptual model for On-Line Analytical Processing (OLAP)-based applications. Apart from providing the functionalities necessary for OLAP-based applications, the main feature of the model we propose is a clear separation between structural aspects and the contents. This separation of concerns allows us to define data manipulation languages in a reasonably simple, transparent way. In particular, we show that the data cube operator can be expressed easily. Concretely, we define an algebra and a calculus and show them to be equivalent. We conclude by comparing our approach to related work. The conceptual multi-dimensional database model developed here is orthogonal to its implementation, which is not a subject of the present paper.

Attenuation of intravenous amphetamine reinforcement by central dopamine blockade in rats.

Abstract: Norepinephrine (NE) and dopamine (DA) receptor blockade differentially affected amphetamine self-administration. DA blockade (pimozide, 0.0625 to 0.5 mg/kg, or (+)-butaclamol, 0.0125 to 0.1 mg/kg) caused periods of increased rate of responding for amphetamine which were followed, in the case of higher doses, by response cessation. The response cessation produced by 0.5 mg/kg pimozide was not reversed by non-contingent amphetamine injections until well after the peak effect of the pimozide was over. When access to amphetamine injections was delayed until 4 h after animals received 0.5 mg/kg pimozide, rate of responding was elevated. Thus DA seems to be critically involved in mediation of the reinforcing effects of amphetamine. Alpha-NE blockade with phentolamine (2.5–10 mg/kg) produced dose-related decreases in responding; blockade with phenoxybenzamine (1.25–10 mg/kg) had no effect. Beta-NE blockade with l-propranolol (2.5–10 mg/kg) decreased responding, although probably not through a beta-blocking action. The effects of phentolamine and propranolol do not appear to result from attenuation of the reinforcing effects of amphetamine.

The potential of distributed generation to provide ancillary services

Abstract: The growing concerns regarding electric power quality and availability have led to the installation of more and more distributed generation. In parallel and in the context of an accelerating trend towards deregulation of the electric industry, the unbundling of services, many grouped under ancillary services, should create a market for some of these services. This paper discusses the potential of distributed generation (DG) to provide some of these services. In particular, DG can serve locally as the equivalent of a spinning reserve and voltage support of the AC bus. The main types of distributed generation with emphasis on the power electronic interface and the configurations appropriate to provide ancillary services are reviewed. The flexibility and features provided by the power electronic interface are illustrated. In addition to control of the real power, other functions can be incorporated into the design of the interface to provide services, such as reactive power, and resources associated with power quality. These include voltage sag compensation and harmonic filtering. The implications on the design of the power converter interface are discussed.

Work strain, health, and absenteeism: a meta-analysis.

Abstract: Work strain has been argued to be a significant cause of absenteeism in the popular and academic press. However, definitive evidence for associations between absenteeism and strain is currently lacking. A theory focused meta-analysis of 275 effects from 153 studies revealed positive but small associations between absenteeism and work strain, psychological illness, and physical illness. Structural equation modeling results suggested that the strain-absence connection may be mediated by psychological and physical symptoms. Little support was received for the purported volitional distinction between absence frequency and time lost absence measures on the basis of illness. Among the moderators examined, common measurement, midterm and stable sources of variance, and publication year received support.

Comparative genomics reveals high biological diversity and specific adaptations in the industrially and medically important fungal genus Aspergillus

Abstract: Background: The fungal genus Aspergillus is of critical importance to humankind. Species include those with industrial applications, important pathogens of humans, animals and crops, a source of potent carcinogenic contaminants of food, and an important genetic model. The genome sequences of eight aspergilli have already been explored to investigate aspects of fungal biology, raising questions about evolution and specialization within this genus. Results: We have generated genome sequences for ten novel, highly diverse Aspergillus species and compared these in detail to sister and more distant genera. Comparative studies of key aspects of fungal biology, including primary and secondary metabolism, stress response, biomass degradation, and signal transduction, revealed both conservation and diversity among the species. Observed genomic differences were validated with experimental studies. This revealed several highlights, such as the potential for sex in asexual species, organic acid production genes being a key feature of black aspergilli, alternative approaches for degrading plant biomass, and indications for the genetic basis of stress response. A genome-wide phylogenetic analysis demonstrated in detail the relationship of the newly genome sequenced species with other aspergilli. Conclusions: Many aspects of biological differences between fungal species cannot be explained by current knowledge obtained from genome sequences. The comparative genomics and experimental study, presented here, allows for the first time a genus-wide view of the biological diversity of the aspergilli and in many, but not all, cases linked genome differences to phenotype. Insights gained could be exploited for biotechnological and medical applications of fungi.