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Connolly Hospital Blanchardstown

HealthcareDublin, Ireland
About: Connolly Hospital Blanchardstown is a(n) healthcare organization based out in Dublin, Ireland. It is known for research contribution in the topic(s): Population & Ambulatory blood pressure. The organization has 302 authors who have published 213 publication(s) receiving 3858 citation(s). The organization is also known as: James Connolly Memorial Hospital.
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Journal ArticleDOI
TL;DR: It is suggested that obesity-associated asthma is facilitated by inflammation mediated by NLRP3, IL-1β and ILC3 cells, which is found in the bronchoalveolar lavage fluid of individuals with asthma.
Abstract: The mechanisms underlying the association between obesity and the development of asthma remain incompletely understood. Dale T. Umetsu and his colleagues report that the number of IL-17A+ type 3 innate lymphoid cells (ILCs) is increased in the lungs of mice fed a high-fat diet. Activation of the NLRP3 inflammasome in lung macrophages promotes IL-1β production and ILC development, and blockade of IL-1 signaling inhibits airway hyperreactivity in obese mice. As these ILCs are also found in the lungs of individuals with asthma, these results suggest that this pathway may be targeted in asthma.

416 citations

Journal ArticleDOI
TL;DR: Recent evidence has shown that miRNAs in the circulation may reflect underlying disease states and hence serve as potential markers for disease activity.
Abstract: Summary Introduction Osteoarthritis (OA) is a common disease worldwide leading to significant morbidity. The underlying disease process is multifactorial however there is increasing focus on molecular mechanisms. MicroRNAs are small non-coding segments of RNA that have important regulatory functions at a cellular level. These molecules are readily detectable in human tissues and circulation. They are increasingly recognised as having a major role in many disease processes – including malignancy and inflammatory processes. Objective This review paper aims to provide a comprehensive update on the evidence for miRNA roles in OA. Design A comprehensive literature search was performed using key medical subject headings (MeSH) terms ‘microRNA' and ‘osteoarthritis'. Results Several miRNAs have been identified as having aberrant expression levels in OA. Some of these include miR-9 , miR-27 , miR-34a , miR-140 , miR-146a , miR-558 and miR-602 . Many of the dysregulated miRNAs have been shown to regulate expression of inflammatory pathways such as interleukin-mediated or matrix metalloproteinase-13 (MMP-13)-mediated degradation of the articular cartilage extracellular matrix (ECM). MiRNAs may also play a role in pain pathways and hence expression of clinical symptoms. Conclusions Recent evidence has shown that miRNAs in the circulation may reflect underlying disease states and hence serve as potential markers for disease activity. These findings may represent possible future therapeutic applications in the management of OA.

147 citations

Journal ArticleDOI
TL;DR: Preoperative chemotherapy for locoregional gastroesophageal adenocarcinoma increases survival compared to surgery alone and should be offered to all eligible patients.
Abstract: Background The prognosis of patients with gastroesophageal adenocarcinoma is poor. There is conflicting evidence regarding effects of preoperative chemotherapy on survival and other outcomes. Methods We conducted a meta-analysis with aggregate and individual patient data (IPD) to assess the effect of preoperative chemotherapy for gastroesophageal adenocarcinoma on survival and other outcomes. Two independent reviewers identified eligible randomised controlled trials (RCTs) comparing chemotherapy+/-radiotherapy followed by surgery with surgery alone for gastroesophageal adenocarcinoma. IPD was solicited from all trials. Meta-analyses were performed using the two stage method. Results We identified 14 RCTs (2422 patients). For eight RCTs (1049 patients; 43.3%) we obtained IPD. Preoperative chemotherapy was associated with longer overall survival (hazard ratio [HR] 0.81; 95% confidence interval [CI] 0.73-0.89; p < 0.0001). There were larger treatment effects in tumours of the gastroesophageal junction and for chemoradiotherapy compared to chemotherapy, but the tests for subgroup differences were not statistically significant. Preoperative chemotherapy was associated with longer disease-free survival, higher likelihood of R0 resection and more favourable post-treatment tumour stage, but not perioperative complications. Conclusion Preoperative chemotherapy for locoregional gastroesophageal adenocarcinoma increases survival compared to surgery alone. It should be offered to all eligible patients. There appear to be larger survival advantages in tumours of the gastroesophageal junction and for chemoradiotherapy, but these findings require prospective confirmation.

123 citations

Journal ArticleDOI
01 May 2010-Stroke
TL;DR: The ABCD2 score had predictive utility in patients with TIA suspected by nonspecialists, and low scores occurred in several patients with stroke recurrences, suggesting that caution is needed before using the score in isolation.
Abstract: Background and Purpose— Transient ischemic attack (TIA) etiologic data and the ABCD2 score may improve early stroke risk prediction, but studies are required in population-based cohorts. We investigated the external validity of the ABCD2 score, carotid stenosis, and atrial fibrillation for prediction of early recurrent stroke after TIA. Methods— Patients with TIA in the North Dublin city population (N=294 529) were ascertained by using overlapping hospital and community sources. The relations between individual ABCD2 items, carotid stenosis, atrial fibrillation, and early stroke were examined. Results— In confirmed TIA cases (n=443), carotid stenosis predicted 90-day stroke (hazard ratio=2.56; 95% CI, 1.27 to 5.15, P=0.003). Stroke risk rose with increasing grade of carotid stenosis, ranging from 5.4% (95% CI, 3.3% to 8.7%) with <50% stenosis to 17.2% (95% CI, 9.7% to 29.7%) with severe stenosis/occlusion (hazard ratio=3.3; 95% CI, 1.5 to 7.4, P=0.002). In confirmed TIA cases (n=443), the ABCD2 score perf...

117 citations


Showing all 302 results

James P. O'Gara41875924
Jarushka Naidoo381397798
Thomas N. Walsh311274735
Richard J. Farrell31915176
Conor Burke26652968
Seamus Sreenan24732667
Eamon Dolan24611728
Cathal J. Kelly22561183
John Faul22412163
Eoghan O'Neill19451996
Austin Leahy19831385
Aoife M. Egan18731173
James M. O’Riordan17481294
Conor P Kerley1427450
John H. McDermott1331474
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