Institution
Conservatoire national des arts et métiers
Education•Paris, France•
About: Conservatoire national des arts et métiers is a education organization based out in Paris, France. It is known for research contribution in the topics: Population & Orthogonal frequency-division multiplexing. The organization has 3573 authors who have published 7127 publications receiving 141430 citations. The organization is also known as: CNAM & Conservatoire des arts et métiers.
Topics: Population, Orthogonal frequency-division multiplexing, Petri net, Finite element method, Context (language use)
Papers published on a yearly basis
Papers
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TL;DR: In this article, an abstract bracket formulation of dissipative time evolution equations arising in nonequilibrium statistical mechanics is introduced, which is interpreted as a mathematical formulation of the compatibility of the time evolution equation with equilibrium thermodynamics.
46 citations
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TL;DR: In faecal samples, the enumeration of Bifidobacterium genus in most cases gave higher results with competitive PCR than with culture on selective Columbia-Beerens agar pH 5 (P < 0.05), and cPCR and PCR-TTGE can be associated in order to characterize human faecals.
45 citations
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TL;DR: Comparison of P4507B1 sequences in rat, human, and two mouse species showed that one amino acid change might explain important differences in KM for 7α‐hydroxylation, and suggested that such differences might contribute to the extent of immune response.
Abstract: In human and murine lymphoid organs, circulating 3 beta-hydroxysteroids, including pregnenolone (PREG), dehydroepiandrosterone (DHEA), and epiandrosterone (EPIA), are 7 alpha-hydroxylated by a cytochrome P450 identified in the hippocampus as P4507B1. Mouse and human lymphoid organs produced different patterns of 3 beta-hydroxysteroid 7 alpha-hydroxylation with the absence of pregnenolone and epiandrosterone hydroxylation in human and mouse, respectively. Both 7 alpha-hydroxy-DHEA and 7 alpha-hydroxy-EPIA triggered a significant increase of antitetanus toxoid and anti-Bordetella pertussis toxins IgGs production in cultures of activated B + T cells derived from human tonsils, whereas both 7 alpha-hydroxy-PREG and 7 alpha-hydroxy-DHEA increased the immune response in mouse. Paracrine action of 7 alpha-hydroxysteroids resulted from their production in cells of the lymphoid organs. Comparison of P4507B1 sequences in rat, human, and two mouse species showed that one amino acid change might explain important differences in KM for 7 alpha-hydroxylation, and suggested that such differences might contribute to the extent of immune response.
45 citations
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TL;DR: It is hypothesized that CYP7B1 expression is increased in prostate tumors and that promoter methylation contributes to the regulation of CYP5α‐androstane‐3β,17β‐diol (3βAdiol) in human prostate tissue.
Abstract: BACKGROUND
Cytochrome P450 (CYP) 7B1 is involved in many metabolic processes including androgen metabolism. Cytochrome P450 (CYP) 7B1 is expressed within the prostate and may determine the levels of the natural estrogen receptor β (ERβ) ligand 5α-androstane-3β,17β-diol (3βAdiol) available and hence affect the regulation of prostate proliferation. We hypothesized that CYP7B1 expression is increased in prostate tumors and that promoter methylation contributes to the regulation of CYP7B1 expression in human prostate tissue.
METHODS
Expression of the CYP7B1 gene and protein in clinical prostate tissues and prostate cancer cell lines were investigated using real-time PCR and immunohistochemistry. The methylation status of the CYP7B1 gene was analyzed using methylation-specific PCR (MSP).
RESULTS
The immunohistochemical results demonstrate that high expression of CYP7B1 protein occurs in high-grade prostatic intraepithelial neoplasia (PIN) and adenocarcinomas. The ERβ/CYP7B1 mRNA ratio was significantly lower in tumor compared to the non-tumor area. The MSP analysis indicate that local methylation of CYP7B1 promoter region is an important mechanism involved in down-regulation of CYP7B1 in human prostate tissue.
CONCLUSIONS
This is the first report showing that CYP7B1 is overexpressed in high-grade PIN and in prostate cancer and that local methylation of CYP7B1 promoter region may have significant effect on gene transcription. Prostate 67: 1439–1446, 2007. © 2007 Wiley-Liss, Inc.
45 citations
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TL;DR: It is concluded that conversion of DHEA to estrogens, particularly estradiol, is required to exert a mitogenic response to stimulate cell proliferation and gene expression in MCF-7 breast cancer cells.
45 citations
Authors
Showing all 3635 results
Name | H-index | Papers | Citations |
---|---|---|---|
Joshua A. Salomon | 107 | 435 | 124708 |
Serge Hercberg | 106 | 942 | 56791 |
Pilar Galan | 97 | 628 | 46782 |
Patrice Simon | 89 | 264 | 66332 |
Yuh-Shan Ho | 80 | 346 | 48242 |
Pierre-Louis Taberna | 68 | 209 | 34293 |
J. David Spence | 67 | 399 | 17671 |
Mathilde Touvier | 65 | 321 | 31586 |
Sébastien Czernichow | 64 | 274 | 14654 |
Emmanuelle Kesse-Guyot | 57 | 338 | 10914 |
Valentin Petrov | 54 | 743 | 12127 |
Sandrine Bertrais | 53 | 169 | 9618 |
Paco Bustamante | 52 | 295 | 9136 |
Khaled Ezzedine | 50 | 313 | 8939 |
Arnaud Fontanet | 50 | 204 | 11964 |