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Institution

Conservatoire national des arts et métiers

EducationParis, France
About: Conservatoire national des arts et métiers is a education organization based out in Paris, France. It is known for research contribution in the topics: Population & Orthogonal frequency-division multiplexing. The organization has 3573 authors who have published 7127 publications receiving 141430 citations. The organization is also known as: CNAM & Conservatoire des arts et métiers.


Papers
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Journal ArticleDOI
TL;DR: Four serological assays measuring anti–SARS-CoV-2 antibodies and their neutralizing activity in samples from individuals with severe and mild COVID-19 are compared and enabled a broad evaluation of SARS- CoV- 2 seroprevalence and antibody profiling in different subpopulations within one region.
Abstract: It is of paramount importance to evaluate the prevalence of both asymptomatic and symptomatic cases of SARS-CoV-2 infection and their differing antibody response profiles. Here, we performed a pilot study of four serological assays to assess the amounts of anti-SARS-CoV-2 antibodies in serum samples obtained from 491 healthy individuals before the SARS-CoV-2 pandemic, 51 individuals hospitalized with COVID-19, 209 suspected cases of COVID-19 with mild symptoms, and 200 healthy blood donors. We used two ELISA assays that recognized the full-length nucleoprotein (N) or trimeric spike (S) protein ectodomain of SARS-CoV-2. In addition, we developed the S-Flow assay that recognized the S protein expressed at the cell surface using flow cytometry, and the luciferase immunoprecipitation system (LIPS) assay that recognized diverse SARS-CoV-2 antigens including the S1 domain and the carboxyl-terminal domain of N by immunoprecipitation. We obtained similar results with the four serological assays. Differences in sensitivity were attributed to the technique and the antigen used. High anti-SARS-CoV-2 antibody titers were associated with neutralization activity, which was assessed using infectious SARS-CoV-2 or lentiviral-S pseudotype virus. In hospitalized patients with COVID-19, seroconversion and virus neutralization occurred between 5 and 14 days after symptom onset, confirming previous studies. Seropositivity was detected in 32% of mildly symptomatic individuals within 15 days of symptom onset and in 3% of healthy blood donors. The four antibody assays that we used enabled a broad evaluation of SARS-CoV-2 seroprevalence and antibody profiling in different subpopulations within one region.

193 citations

Journal ArticleDOI
TL;DR: Polysaccharide derivatives have been extensively used as chromatographic chiral selectors in chiral stationary phases (CSPs) for the separation of enantiomers by HPLC, but they are only compatible with a limited choice of solvents, which limits their applicability.

192 citations

Journal ArticleDOI
TL;DR: The Driver-Pressures-State-Impact-Response approach is applied to heavy metals in the Seine River catchment and a general increase of the demand is observed: the rate of recycling and/or treatment of metals within the anthroposphere has been improved ten-fold.

192 citations

Journal ArticleDOI
TL;DR: In this article, cellulose nanowhiskers were grafted by n-octadecyl-isocyanate (CNW-ICN) applying an in situ surface grafting method, and the compatibility of the long aliphatic grafted chain was investigated by thermal, mechanical and permeability analysis of solvent cast nanocomposite films.

191 citations

Journal ArticleDOI
TL;DR: In this paper, a calixarene bearing two dansyl fluorophores was grafted on a large pore mesoporous silica material (SBA-15) with two long alkyl chains containing triethoxysilane groups.
Abstract: With the aim of optical sensing of Hg2+ in water, a calixarene bearing two dansyl fluorophores was grafted on a large pore mesoporous silica material (SBA-15) via two long alkyl chains containing triethoxysilane groups. The characterization of the obtained material 2-SBA-15 shows that the organized structure is preserved after the post-grafting procedure. A detailed study of the complexing and fluorescence properties of 2-SBA-15 is reported. The functionalized material is able to reversibly detect Hg2+ with a response time of a few seconds and a detection limit of 3.3 × 10−7 mol L−1 in water. Furthermore, this system offers a high selectivity over several interfering cations (Na+, K+, Ca2+, Cu2+, Cd2+, Pb2+).

190 citations


Authors

Showing all 3635 results

NameH-indexPapersCitations
Joshua A. Salomon107435124708
Serge Hercberg10694256791
Pilar Galan9762846782
Patrice Simon8926466332
Yuh-Shan Ho8034648242
Pierre-Louis Taberna6820934293
J. David Spence6739917671
Mathilde Touvier6532131586
Sébastien Czernichow6427414654
Emmanuelle Kesse-Guyot5733810914
Valentin Petrov5474312127
Sandrine Bertrais531699618
Paco Bustamante522959136
Khaled Ezzedine503138939
Arnaud Fontanet5020411964
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
20238
2022124
2021383
2020419
2019399
2018362