Conservatoire national des arts et métiers

About: Conservatoire national des arts et métiers is a education organization based out in Paris, France. It is known for research contribution in the topics: Population & Context (language use). The organization has 3573 authors who have published 7127 publications receiving 141430 citations. The organization is also known as: CNAM & Conservatoire des arts et métiers.

Concentration and distribution of heavy metals in tissues of two cephalopods, Eledone cirrhosa and Sepia officinalis , from the French coast of the English Channel

Abstract: The concentrations of 11 heavy metals (Ag, Cd, Co, Cr, Cu, Fe, Mn, Ni, Pb, V and Zn) were measured in the tissues (digestive gland, branchial hearts, gills, digestive tract, kidney, genital tract, muscle, skin, shell) of the two cephalopods Eledone cirrhosa (d'Orb.) and Sepia officinalis (L.) collected from the French coast of the English Channel in October 1987. The tissues of both species displayed a similar pattern of heavy-metal accumulation: the digestive gland, branchial hearts and kidney were the major sites of concentration for all 11 metals; the digestive gland accumulated silver, cadmium, cobalt, copper, iron, lead and zinc, the branchial hearts high concentrations of copper, nickel and vanadium, and the kidney high concentrations of manganese, nickel and lead. The digestive gland, which constituted 6 to 10% of the whole-animal tissue, contained >80% of the total body burden of Ag, Cd and Co and from 40 to 80% of the total body burden of the other metals. The ratios between heavy metal concentrations in the digestive gland and those in the muscle separated the elements into three groups, those with a ratio ≤10 (Cr, Mn, Ni, Pb, V, Zn), those with a ratio >10 to <50 (Co, Cu, Fe), and those with a ratio ≥50 (Ag, Cd). The digestive gland of cephalopods (carnivorous molluscs whose age can be easily calculated with great accuracy) would seem to constitute a good potential indicator of heavy metal concentrations in the marine environment.

CD39/Adenosine Pathway Is Involved in AIDS Progression

Abstract: HIV-1 infection is characterized by a chronic activation of the immune system and suppressed function of T lymphocytes. Regulatory CD4+ CD25(high) FoxP3+CD127(low) T cells (Treg) play a key role in both conditions. Here, we show that HIV-1 positive patients have a significant increase of Treg-associated expression of CD39/ENTPD1, an ectoenzyme which in concert with CD73 generates adenosine. We show in vitro that the CD39/adenosine axis is involved in Treg suppression in HIV infection. Treg inhibitory effects are relieved by CD39 down modulation and are reproduced by an adenosine-agonist in accordance with a higher expression of the adenosine A2A receptor on patients' T cells. Notably, the expansion of the Treg CD39+ correlates with the level of immune activation and lower CD4+ counts in HIV-1 infected patients. Finally, in a genetic association study performed in three different cohorts, we identified a CD39 gene polymorphism that was associated with down-modulated CD39 expression and a slower progression to AIDS.

Impact of metformin on the prognosis of cirrhosis induced by viral hepatitis C in diabetic patients.

Abstract: Context: Insulin resistance plays a role in hepatocarcinogenesis and is decreased by metformin treatment. Objective: The aim of the study was to assess the influence of metformin treatment on the prognosis of compensated hepatitis C virus (HCV) cirrhosis in patients with type 2 diabetes. Design and Setting: We studied an observational prospective cohort (1988–2007) at a university hospital referral center. Patients: A total of 100 consecutive diabetic patients (53 men, age 61 ± 11 yr) with ongoing HCV cirrhosis and no contraindication for metformin were included in a screening program for hepatocellular carcinoma (HCC). Main Outcomes: The patients were prospectively followed up for HCC incidence, liver-related death, or hepatic transplantation. Results: The level of platelet count was significantly lower in patients treated with metformin (n = 26) compared with those not treated with metformin (n = 74) [117 (interquartile range, 83–166) vs. 149 (105–192) Giga/liter, P = 0.045]. During a median follow-up o...

Geophysical muon imaging: feasibility and limits

Abstract: SUMMARY We study the possibility of muon radiography as a tool to investigate space and time changes in the internal density distribution inside geological structures. Previous work has shown the practical applicability of this method. Nevertheless, quantitative information on factors which impose limitations on it are still sorely lacking in the literature. We discuss the main issues that can influence the final result of a geophysical imaging experiment. In particular, with the view of optimizing the signal-to-noise ratio, we address issues concerning (i) the energy spectrum for muons arriving at different zenith angles, (ii) the muon propagation model through matter and (iii) the characteristics of the muon detector (telescope) that we have designed to perform experiments of muon radiography against the harsh environment usually encountered in the active zone of a volcano. We thus identify factors that can induce either static or dynamic effects and that should be taken into account. We also define a feasibility eq. (32) relating the geometrical characteristics of the telescope and the duration of the experiment to the expected density resolution, in turn a function of the geometrical characteristics of the target structure. This relation is especially important to define the applicability domain of muon radiography and it is utilized to test the suitability of the method to investigate the density distribution inside some candidate target structures.

Association between dietary patterns and depressive symptoms over time: a 10-year follow-up study of the GAZEL cohort.

Abstract: Background Data on the association between dietary patterns and depression are scarce. The objective of this study was to examine the longitudinal association between dietary patterns and depressive symptoms assessed repeatedly over 10 years in the French occupational GAZEL cohort.