Institution
Conservatoire national des arts et métiers
Education•Paris, France•
About: Conservatoire national des arts et métiers is a education organization based out in Paris, France. It is known for research contribution in the topics: Population & Context (language use). The organization has 3573 authors who have published 7127 publications receiving 141430 citations. The organization is also known as: CNAM & Conservatoire des arts et métiers.
Topics: Population, Context (language use), Orthogonal frequency-division multiplexing, Petri net, Finite element method
Papers published on a yearly basis
Papers
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TL;DR: Daniellou et al. as discussed by the authors discussed the role of activity analysis in a participatory design process and presented the results of an a posteriori analysis of the participatory process in one of the two interventions.
145 citations
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École Polytechnique Fédérale de Lausanne1, Swiss Institute of Bioinformatics2, Conservatoire national des arts et métiers3, Max Planck Society4, Harvard University5, Broad Institute6, Brigham and Women's Hospital7, Massachusetts Institute of Technology8, Leidos9, University of Modena and Reggio Emilia10, Autonomous University of Barcelona11, University of Siena12, University of Cambridge13, Wellcome Trust Sanger Institute14, Vanderbilt University15, University of Washington16, Research Triangle Park17, Johns Hopkins University18, French Institute of Health and Medical Research19, University of Manitoba20, Murdoch University21, University of Amsterdam22, Catalan Institution for Research and Advanced Studies23, University of Barcelona24, Copenhagen University Hospital25, Università telematica San Raffaele26, Vita-Salute San Raffaele University27, Columbia University28, Howard Hughes Medical Institute29, Uniformed Services University of the Health Sciences30, Northwestern University31, University of Manchester32, J. Craig Venter Institute33, Utrecht University34
TL;DR: Heritability analysis demonstrated that common human genetic variation—mostly in the HLA and CCR5 regions—explains 25% of the variability in viral load.
Abstract: Previous genome-wide association studies (GWAS) of HIV-1–infected populations have been underpowered to detect common variants with moderate impact on disease outcome and have not assessed the phenotypic variance explained by genome-wide additive effects. By combining the majority of available genome-wide genotyping data in HIV-infected populations, we tested for association between ∼8 million variants and viral load (HIV RNA copies per milliliter of plasma) in 6,315 individuals of European ancestry. The strongest signal of association was observed in the HLA class I region that was fully explained by independent effects mapping to five variable amino acid positions in the peptide binding grooves of the HLA-B and HLA-A proteins. We observed a second genome-wide significant association signal in the chemokine (C-C motif) receptor (CCR) gene cluster on chromosome 3. Conditional analysis showed that this signal could not be fully attributed to the known protective CCR5Δ32 allele and the risk P1 haplotype, suggesting further causal variants in this region. Heritability analysis demonstrated that common human genetic variation—mostly in the HLA and CCR5 regions—explains 25% of the variability in viral load. This study suggests that analyses in non-European populations and of variant classes not assessed by GWAS should be priorities for the field going forward.
144 citations
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TL;DR: The bacterial diversity in faeces of preterm infants was investigated using analysis of randomly cloned 16S rRNA genes and PCR-TTGE (temporal temperature gradient gel electrophoresis) profiles, to determine whether noncultivated bacteria represented an important part of the community.
144 citations
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TL;DR: The findings suggest that selenium may protect against goiter, and Selenium was related to thyroid echostructure, suggesting it may also protect against autoimmune thyroid disease.
Abstract: Objective: To investigate the relationship between selenium status, thyroid volume and gland echostructure. Design: Cross-sectional. Methods: In 792 men (45 – 60 years) and 1108 women (35 – 60 years) from the SU.VI.MAX study, thyroid volume and gland echostructure were determined ultrasonographically. At baseline, thyrotropin, free thyroxine, selenium, zinc, a-tocopherol, b-carotene, retinol, urinary iodine and thiocyanate concentrations were measured. Alcohol consumption, smoking, and menopausal status were assessed by a questionnaire. A stepwise linear and a logistic regression model were used, adjusting for antioxidant vitamins, trace elements status and age. Results: In women, there was an inverse association between selenium status and thyroid volume ðP ¼ 0:003Þ: A protective effect of selenium against goiter (odds ratio ðOR Þ¼ 0:07; 95% confidence interval ðCI Þ¼ 0:008 – 0:6) and thyroid tissue damage ðOR ¼ 0:2; 95% CI ¼ 0:06 – 0:7Þ was observed. There was no evidence of an association between menopausal status and other antioxidant elements, thyroid volume or thyroid hypoechogenicity. Smoking, but not alcohol consumption, was associated with an increased risk of thyroid enlargement in women ðOR ¼ 3:94; 95% CI ¼ 1:64 – 9:48Þ: No association between thyroid volume, thyroid structure or selenium was found in men. Conclusion: Our findings suggest that selenium may protect against goiter. Selenium was related to thyroid echostructure, suggesting it may also protect against autoimmune thyroid disease.
143 citations
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TL;DR: In this paper, the relevance of structural breaks and long memory in modeling and forecasting the conditional volatility of oil spot and futures prices using a variety of GARCH-type models was investigated.
143 citations
Authors
Showing all 3635 results
Name | H-index | Papers | Citations |
---|---|---|---|
Joshua A. Salomon | 107 | 435 | 124708 |
Serge Hercberg | 106 | 942 | 56791 |
Pilar Galan | 97 | 628 | 46782 |
Patrice Simon | 89 | 264 | 66332 |
Yuh-Shan Ho | 80 | 346 | 48242 |
Pierre-Louis Taberna | 68 | 209 | 34293 |
J. David Spence | 67 | 399 | 17671 |
Mathilde Touvier | 65 | 321 | 31586 |
Sébastien Czernichow | 64 | 274 | 14654 |
Emmanuelle Kesse-Guyot | 57 | 338 | 10914 |
Valentin Petrov | 54 | 743 | 12127 |
Sandrine Bertrais | 53 | 169 | 9618 |
Paco Bustamante | 52 | 295 | 9136 |
Khaled Ezzedine | 50 | 313 | 8939 |
Arnaud Fontanet | 50 | 204 | 11964 |