Conservatoire national des arts et métiers

About: Conservatoire national des arts et métiers is a education organization based out in Paris, France. It is known for research contribution in the topics: Population & Context (language use). The organization has 3573 authors who have published 7127 publications receiving 141430 citations. The organization is also known as: CNAM & Conservatoire des arts et métiers.

Partial least squares algorithms and methods

Abstract: Partial least squares (PLS) refers to a set of iterative algorithms based on least squares that implement a broad spectrum of both explanatory and exploratory multivariate techniques, from regression to path modeling, and from principal component to multi-block data analysis. This article focuses on PLS regression and PLS path modeling, which are PLS approaches to regularized regression and to predictive path modeling. The computational flows and the optimization criteria of these methods are reviewed in detail, as well as the tools for the assessment and interpretation of PLS models. The most recent developments and some of the most promising on going researches are enhanced. WIREs Comput Stat 2013, 5:1–19. doi: 10.1002/wics.1239

The Pro115Gln and Pro12Ala PPAR gamma gene mutations in obesity and type 2 diabetes.

Abstract: OBJECTIVE: Peroxisome-proliferator-activated receptors γ (PPAR γ), is a key regulator of adipocyte differentiation and energy balance. Two naturally occurring mutations in the PPAR γ gene, Pro115Gln and Pro12Ala, have recently been shown to impair the function of the PPARγ2 isoform of the receptor and to be associated with obesity or diabetes- related phenotypes in different populations. SUBJECTS: We studied the occurrence and possible associations of the Pro115Gln and Pro12Ala in the PPAR γ2 gene with several clinical and metabolic phenotypes in three independent large populations of non-obese non-diabetic, type 2 diabetic, and morbidly obese French Caucasians. RESULTS: The Pro115Gln mutation was not found in any of the 1069 subjects screened including 626 obese patients. The frequency of the Pro12Ala mutation was similar in all groups (0.08, 0.11,0.09) and was not associated with BMI or any of the clinical parameters tested. CONCLUSIONS: We conclude that the Pro115Gln mutation is not a frequent cause of morbid obesity in Caucasians and that the Pro12Ala mutation is not associated with clinically significant changes in these populations.

First- and Third-Person Perspectives in Immersive Virtual Environments: Presence and Performance Analysis of Embodied Users

Abstract: Current design of virtual reality (VR) applications relies essentially on the transposition of users' viewpoint in first-person perspective (1PP). Within this context, our research aims to compare the impact and the potentialities enabled via the integration of the third-person perspective (3PP) in immersive virtual environments (IVE). Our empirical study is conducted in order to assess the sense of presence, the sense of embodiment and performance of users confronted with a series of tasks presenting a case of potential use for the video game industry. Our results do not reveal significant differences concerning the sense of spatial presence with either point of view. Nonetheless, they provide evidence confirming the relevance of using the first-person perspective to induce a sense of embodiment toward a virtual body, especially in terms of self-location and ownership. However, no significant differences were observed concerning the sense of agency. Concerning users' performance, our results demonstrate that the first-person perspective enables more accurate interactions, while the third-person perspective provides better space awareness.