Institution
Conservatoire national des arts et métiers
Education•Paris, France•
About: Conservatoire national des arts et métiers is a education organization based out in Paris, France. It is known for research contribution in the topics: Population & Orthogonal frequency-division multiplexing. The organization has 3573 authors who have published 7127 publications receiving 141430 citations. The organization is also known as: CNAM & Conservatoire des arts et métiers.
Topics: Population, Orthogonal frequency-division multiplexing, Petri net, Finite element method, Context (language use)
Papers published on a yearly basis
Papers
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TL;DR: A multi-strain mixture was able to improve adiposity, insulin resistance and dyslipidemia through adipose tissue immune cell-remodelling, mainly affecting macrophages, and it was shown that the probiotic mixture favours the production of butyrate and propionate.
Abstract: Alterations in gut microbiota composition and diversity were suggested to play a role in the development of obesity, a chronic subclinical inflammatory condition. We here evaluated the impact of oral consumption of a monostrain or multi-strain probiotic preparation in high-fat diet-induced obese mice. We observed a strain-specific effect and reported dissociation between the capacity of probiotics to dampen adipose tissue inflammation and to limit body weight gain. A multi-strain mixture was able to improve adiposity, insulin resistance and dyslipidemia through adipose tissue immune cell-remodelling, mainly affecting macrophages. At the gut level, the mixture modified the uptake of fatty acids and restored the expression level of the short-chain fatty acid receptor GPR43. These beneficial effects were associated with changes in the microbiota composition, such as the restoration of the abundance of Akkermansia muciniphila and Rikenellaceae and the decrease of other taxa like Lactobacillaceae. Using an in vitro gut model, we further showed that the probiotic mixture favours the production of butyrate and propionate. Our findings provide crucial clues for the design and use of more efficient probiotic preparations in obesity management and may bring new insights into the mechanisms by which host-microbe interactions govern such protective effects.
121 citations
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TL;DR: The modifications in the various regional ecosystems in the gastrointestinal tract during inflammatory bowel disease are summarized and the possibility of modifying the ecosystem using prebiotics or probiotics offers hope for new treatment developments, particularly in the prevention of relapse.
Abstract: The pathogenesis of inflammatory bowel disease involves interactions between the host susceptibility, mucosal immunity and intestinal microflora. There is therefore great interest in the changes in the endogenous flora in inflammatory bowel disease patients and in the establishment of potential genetic variations in host responses to endogenous bacteria. In this review, we summarize the modifications in the various regional ecosystems in the gastrointestinal tract during inflammatory bowel disease (luminal bacteria in faeces or inside the gastrointestinal tract, bacteria in mucus and bacteria directly attached to the mucosa). Results were obtained following a 'candidate microorganism strategy' and, as is occurring increasingly frequently, following a 'full description strategy', which has progressed largely due to the development of culture-independent techniques. The possibility of modifying the ecosystem using prebiotics or probiotics offers hope for new treatment developments, particularly in the prevention of relapse.
121 citations
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TL;DR: This paper presents QCR, a general method to reformulate (QP) into an equivalent 0-1 program with a convex quadratic objective function, and shows that QCR is optimal in a certain sense.
120 citations
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TL;DR: In this article, a correlation between molar mass and strain at break during polylactide degradation has been established: PLA displays a brittle behavior when Mn falls below 40 kg−1 in agreement with relationships linking the critical value for embrittlement with the molar masses between entanglements.
120 citations
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15 Oct 2007
TL;DR: Zenon is intended to be the dedicated prover of the Focal environment, an objectoriented algebraic specification and proof system, which is able to produce OCaml code for execution and Coq code for certification.
Abstract: We present Zenon, an automated theorem prover for first order classical logic (with equality), based on the tableau method. Zenon is intended to be the dedicated prover of the Focal environment, an objectoriented algebraic specification and proof system, which is able to produce OCaml code for execution and Coq code for certification. Zenon can directly generate Coq proofs (proof scripts or proof terms), which can be reinserted in the Coq specifications produced by Focal. Zenon can also be extended, which makes specific (and possibly local) automation possible in Focal.
120 citations
Authors
Showing all 3635 results
Name | H-index | Papers | Citations |
---|---|---|---|
Joshua A. Salomon | 107 | 435 | 124708 |
Serge Hercberg | 106 | 942 | 56791 |
Pilar Galan | 97 | 628 | 46782 |
Patrice Simon | 89 | 264 | 66332 |
Yuh-Shan Ho | 80 | 346 | 48242 |
Pierre-Louis Taberna | 68 | 209 | 34293 |
J. David Spence | 67 | 399 | 17671 |
Mathilde Touvier | 65 | 321 | 31586 |
Sébastien Czernichow | 64 | 274 | 14654 |
Emmanuelle Kesse-Guyot | 57 | 338 | 10914 |
Valentin Petrov | 54 | 743 | 12127 |
Sandrine Bertrais | 53 | 169 | 9618 |
Paco Bustamante | 52 | 295 | 9136 |
Khaled Ezzedine | 50 | 313 | 8939 |
Arnaud Fontanet | 50 | 204 | 11964 |