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Showing papers by "Cranfield University published in 2003"


Posted Content
TL;DR: The extent to which the process of systematic review can be applied to the management field in order to produce a reliable knowledge stock and enhanced practice by developing context-sensitive research is evaluated.
Abstract: Undertaking a review of the literature is an important part of any research project. The researcher both maps and assesses the relevant intellectual territory in order to specify a research question which will further develop the knowledge base. However, traditional 'narrative' reviews frequently lack thoroughness, and in many cases are not undertaken as genuine pieces of investigatory science. Consequently they can lack a means for making sense of what the collection of studies is saying. These reviews can be biased by the researcher and often lack rigour. Furthermore, the use of reviews of the available evidence to provide insights and guidance for intervention into operational needs of practitioners and policymakers has largely been of secondary importance. For practitioners, making sense of a mass of often-contradictory evidence has become progressively harder. The quality of evidence underpinning decision-making and action has been questioned, for inadequate or incomplete evidence seriously impedes policy formulation and implementation. In exploring ways in which evidence-informed management reviews might be achieved, the authors evaluate the process of systematic review used in the medical sciences. Over the last fifteen years, medical science has attempted to improve the review process by synthesizing research in a systematic, transparent, and reproducible manner with the twin aims of enhancing the knowledge base and informing policymaking and practice. This paper evaluates the extent to which the process of systematic review can be applied to the management field in order to produce a reliable knowledge stock and enhanced practice by developing context-sensitive research. The paper highlights the challenges in developing an appropriate methodology.

7,368 citations


Journal ArticleDOI
TL;DR: In this article, the authors evaluate the process of systematic review used in the medical sciences to produce a reliable knowledge stock and enhanced practice by developing context-sensitive research and highlight the challenges in developing an appropriate methodology.
Abstract: Undertaking a review of the literature is an important part of any research project. The researcher both maps and assesses the relevant intellectual territory in order to specify a research question which will further develop the knowledge hase. However, traditional 'narrative' reviews frequently lack thoroughness, and in many cases are not undertaken as genuine pieces of investigatory science. Consequently they can lack a means for making sense of what the collection of studies is saying. These reviews can he hiased by the researcher and often lack rigour. Furthermore, the use of reviews of the available evidence to provide insights and guidance for intervention into operational needs of practitioners and policymakers has largely been of secondary importance. For practitioners, making sense of a mass of often-contrad ictory evidence has hecome progressively harder. The quality of evidence underpinning decision-making and action has heen questioned, for inadequate or incomplete evidence seriously impedes policy formulation and implementation. In exploring ways in which evidence-informed management reviews might be achieved, the authors evaluate the process of systematic review used in the medical sciences. Over the last fifteen years, medical science has attempted to improve the review process hy synthesizing research in a systematic, transparent, and reproducihie manner with the twin aims of enhancing the knowledge hase and informing policymaking and practice. This paper evaluates the extent to which the process of systematic review can be applied to the management field in order to produce a reliable knowledge stock and enhanced practice by developing context-sensitive research. The paper highlights the challenges in developing an appropriate methodology.

7,020 citations


Journal ArticleDOI
TL;DR: In this article, a review of the existing literature on supply chain vulnerability and risk management is reviewed and compared with findings from exploratory interviews undertaken to discover practitioners' perceptions of supply chain risk and current risk managem...
Abstract: In recent years the issue of supply chain risk has been pushed to the fore, initially by fears related to possible disruptions from the much publicised “millennium bug”. Y2K passed seemingly without incident, though the widespread disruptions caused by fuel protests and then Foot and Mouth Disease in the UK, and by terrorist attacks on the USA have underlined the vulnerability of modern supply chains. Despite increasing awareness among practitioners, the concepts of supply chain vulnerability and its managerial counterpart supply chain risk management are still in their infancy. This paper seeks to identify an agenda for future research and to that end the authors go on to clarify the concept of supply chain risk management and to provide a working definition. The existing literature on supply chain vulnerability and risk management is reviewed and compared with findings from exploratory interviews undertaken to discover practitioners' perceptions of supply chain risk and current supply chain risk managem...

1,429 citations


Journal ArticleDOI
TL;DR: In this paper, the authors reviewed recent research on fiber optic long-period gratings (LPGs) with emphasis placed upon the characteristics of LPGs that make them attractive for applications in sensing strain, temperature, bend radius and external index of refraction.
Abstract: Recent research on fibre optic long-period gratings (LPGs) is reviewed with emphasis placed upon the characteristics of LPGs that make them attractive for applications in sensing strain, temperature, bend radius and external index of refraction. The prospect of the development of multi-parameter sensors, capable of simultaneously monitoring a number of these measurands will be discussed.

1,203 citations


Journal ArticleDOI
TL;DR: Too little is known about the effects of these compounds, their metabolites, and degradation products on human health and the environment.
Abstract: Too little is known about the effects of these compounds, their metabolites, and degradation products.

776 citations


Journal ArticleDOI
TL;DR: In this paper, a review summarises what is known about critical thresholds of soil organic carbon (SOM) or SOM, mainly in soils of temperate regions, and their potential effects on soil quality, soil physical properties and crop nutrition, and the links between these.
Abstract: Soil organic matter (SOM) is a complex mixture, which influences a number of soil properties and nutrient cycling, and is itself influenced in kind and amount by land-use, soil type, climate and vegetation. There is considerable concern that, if SOM concentrations in soils are allowed to decrease too much, then the productive capacity of agriculture will be compromised by deterioration in soil physical properties and by impairment of soil nutrient cycling mechanisms. This has clear implications for the sustainable use of soil. We have focussed our discussion from the standpoint of the sustainability of UK agriculture, because we know that best, but similar concerns are equally valid elsewhere in the world. Although soil scientists would expect to find different behaviour in different soils at different ‘critical’ concentrations of SOM, it seems widely believed that a major threshold is 2% soil organic carbon (SOC) (ca. 3.4% SOM), below which potentially serious decline in soil quality will occur. This review summarises what is known about critical thresholds of SOC or SOM, mainly in soils of temperate regions. It examines critically the quantitative, rather than anecdotal or descriptive, evidence for such thresholds and their potential effects on soil quality, soil physical properties and crop nutrition, and the links between these. We conclude that the quantitative evidence for such thresholds is slight, although there is some evidence that there might be an desirable range of SOC covering a wide spectrum of soils, but again the quantitative evidence for this needs considerable development. There is also little quantitative evidence that reduction in SOC concentrations in the soils of England and Wales will have marked effects on other soil properties or crop yields. The data do suggest, however, that more research is required on the nature of SOC, particularly of the so-called ‘active’ or ‘fresh’ fraction and its influence on the properties of a range of soil types under different land uses. This is particularly relevant to the ongoing debate about soil quality, its definition, and the identification of appropriate indicators that relate soil quality to soil functions.

721 citations


Journal ArticleDOI
TL;DR: In this article, the authors present case study research that investigates what actions organizations can take to ensure that their measurement systems evolve over time, in order to reflect their current environment and strategies.
Abstract: The design and use of performance measurement systems has received considerable attention in recent years. Many organisations have redesigned their measurement systems to ensure that they reflect their current environment and strategies. However, increasingly the environment in which organisations compete is dynamic and rapidly changing, requiring constant modification of strategies and operations to reflect these changing circumstances. Despite this, few organisations appear to have systematic processes in place to ensure that their performance measurement systems continue to reflect their environment and strategies. This paper presents case study research that investigates what actions organisations can take to ensure that their measurement systems evolve over time.

625 citations


Journal ArticleDOI
TL;DR: A new genus and species of anaerobic ammonium oxidizing planctomycetes, discovered in a wastewater treatment plant treating landfill leachate in Pitsea, UK, are described, making this genus the most widespread of all anammox bacteria described so far.

591 citations


Journal ArticleDOI
TL;DR: In this article, a standard flux-step method has been developed for assessing fouling in a membrane bioreactor operating at constant flux, and three parameters based on transmembrane pressure (TMP) were derived to depict fouling behaviour and identify the onset of fouling at the so-called critical flux.

515 citations


Journal ArticleDOI
TL;DR: The literature on performance measurement system implementations is reviewed and it is concluded that the performance measurement literature is at the stage of identifying difficulties and pitfalls to be avoided based on practitioner experience with few published research studies.
Abstract: Currently, there is a great interest in performance measurement with many companies attempting to implement the balanced scorecard. However, there is also evidence that many of these implementations are not successful. This paper reviews the different performance measurement system design processes published in the literature and creates a framework for comparing alternative approaches. The paper then proceeds to review the literature on performance measurement system implementations and concludes that the performance measurement literature is at the stage of identifying difficulties and pitfalls to be avoided based on practitioner experience with few published research studies. This paper is the first of two, the second going on to consider performance measurement implementation from the point of view of the change management literature.

506 citations


Journal ArticleDOI
TL;DR: In this article, the authors consider the emerging focus in both academic and practitioner literature on the concept of the corporate brand and argue that the underlying generative mechanisms and processes that enable successful corporate brand management are not clearly understood.
Abstract: This paper considers the emerging focus in both academic and practitioner literature on the concept of the corporate brand and argues that the underlying generative mechanisms and processes that enable successful corporate brand management are not clearly understood. Based on the findings of recent fieldwork, the authors outline six new conventions for understanding the processes of nurturing and managing a corporate brand and discuss the implications of these conventions for the emergent theory of corporate brand management. Evidence from this work has also led the authors to propose a more holistic definition of the corporate brand, “the visual, verbal and behavioural expression of an organisation's unique business model”.

Journal ArticleDOI
TL;DR: In-depth case study research in 12 Portuguese manufacturing SMEs identified two factors that appeared to be the determinants of the different levels of success in IS/IT adoption and use, and were primarily associated with the internal context of the organisations.
Abstract: The purpose of this paper is to consider how resource-based theory can be used to explain success with the adoption and use of information systems and information technology (IS/IT) in manufacturing small and medium-sized enterprises (SMEs). A number of authors have explored the applicability of resource-based theory to the IS/IT domain, mainly at a conceptual level. Overall they infer that the key differentiators for long-term successful IS/IT deployment reside within the internal context of an organisation, based on organisational competences. This paper is based on in-depth case study research in 12 Portuguese manufacturing SMEs, which identified two factors that, from the empirical evidence, appeared to be the determinants of the different levels of success in IS/IT adoption and use. These factors were also primarily associated with the internal context of the organisations. Therefore, the findings were analysed from the perspective of resource-based theory, to understand why and how the attributes of these factors caused the differential levels of IS/IT success in the firms studied.

Journal ArticleDOI
TL;DR: In this article, the authors report on the results of a systematic investigation into the theoretical underpinnings of why firms measure their Intellectual Capital (IC) and existing empirical evidence that helps to prove that the measurement of IC is really worthwhile.
Abstract: It is now generally believed, within the current literature, that an academic and practitioner focus on intellectual capital (IC) is important and that the measurement of a company's intangibles provides real business benefits. However, it is essential for researchers in the field of IC to be able to justify these newly formed theoretical assumptions through rigorous empirical testing. This paper reports on the results of a systematic investigation into the theoretical underpinnings of why firms measure their IC and existing empirical evidence that helps to prove that the measurement of IC is really worthwhile. The paper then critically reviews the state of research evidence in the field. The major finding of this paper is that the majority of research within the IC measurement field is at the theory building stage, and that very little of the proposed measurement theory has yet been fully tested. This paper outlines possible avenues scholars might pursue in order to further the development of the IC measurement field.

Journal ArticleDOI
TL;DR: In this article, the primary dynamic capabilities identified by Teece, Pisano and Shuen (1997) are elaborated into six distinct modes of resource creation and each mode is considered in relation to a set of organizational design parameters.
Abstract: Summary This paper explains that the resource-based view essentially addresses issues of competitive strategy, but by integrating some arguments from its evolutionary version, the dynamic capability view, it can be extended to inform our understanding of corporate-level strategy. We concentrate on the issue of value creation from corporate centres and ask how the centre can possess or provide resources. The primary dynamic capabilities identified by Teece, Pisano and Shuen (1997) are elaborated into six distinct modes of resource creation. Each mode is considered in relation to a set of organizational design parameters. We then propose resource-creating configurations that are congruent with respect to the modes and the required states of the design parameters. We point out areas of tension that are likely to arise if corporations try to combine different modes of resource creation. We conclude that corporate centres may possess resources but must display dynamic capabilities otherwise they will destroy shareholder value.

Journal ArticleDOI
TL;DR: It is concluded that the contextual demands for knowledge application dictate which pathway to pursue in knowledge management, and how knowledge is absorbed raises the question as to whether focus should be placed on knowledge transfer or knowledge management.
Abstract: Academic and practitioner interpretations of knowledge management are captured through a comprehensive taxonomy of knowledge models. How knowledge is absorbed raises the question as to whether focus should be placed on knowledge transfer or knowledge management. It is concluded that the contextual demands for knowledge application dictate which pathway to pursue.

Journal ArticleDOI
TL;DR: In this article, the effects of weld residual stress and heat affected zone on the fatigue propagation of cracks parallel and orthogonal to the weld direction in friction stir welded (FSW) 2024-T351 joints were investigated.

Journal ArticleDOI
TL;DR: In this paper, the authors used data from research on how managers in an organization undergoing transformation experience change to demonstrate that middle managers fulfil a complex "change intermediary" position during implementation, and that a key aspect of this position is the need for middle managers to engage in a range of activities to aid their interpretation of the change intent.
Abstract: Middle managers have been under attack as organizational downsizing and reengineering have reduced their number. They are also frequently portrayed as obstructive and resistant to change. However, recent research suggests that managers at middle levels in organizations may be able to make a strategic contribution. Data from research on how managers in an organization undergoing transformation experience change are used to build on this existing research to demonstrate that middle managers fulfil a complex ‘change intermediary’ position during implementation. The findings reveal that a key aspect of this position is the need for middle managers to engage in a range of activities to aid their interpretation of the change intent. This interpretation activity then informs the personal changes they attempt to undertake, how they help others through change, how they keep the business going during the transition and what changes they implement in their departments. The interpretation aspect of their role is often overlooked, leading to workload issues and role conflict. These findings offer an alternative perspective on perceived middle manager resistance and lead into suggestions for future research and organizational implications.

Journal ArticleDOI
TL;DR: Business performance measurement (BPM) is a fast evolving and diverse research field which features highly on the agenda of academics and practitioners from functions including general management, accounting, operations research, marketing, and human resources.
Abstract: Business performance measurement (BPM) is a fast evolving and diverse research field which features highly on the agenda of academics and practitioners from functions including general management, accounting, operations research, marketing, and human resources. Utilizing a citation analysis this paper identifies the following challenges for the field of BPM. The balanced scorecard seems to be the most influential and dominant concept in the field. Researchers are encouraged to further test and discuss its theoretical foundation and research methodology. The second challenge is to create a cohesive body of knowledge in the field of BPM.

Journal ArticleDOI
TL;DR: Biological soil thin-sections and a combination of image analysis and geostatistical tools were used to conduct a detailed investigation into the distribution of bacteria in soil and their relationship with pores, finding that bacterial density was greatest close to pores and decreased thereafter.

Book ChapterDOI
TL;DR: A more holistic ecological view is needed when considering management approaches to long-term-safe storage of cereal grains after harvest.
Abstract: Grain quality after harvest is influenced by a wide variety of abiotic and biotic factors and has been studied as a stored grain ecosystem. Important factors include grain and contaminant mould respiration, insects and mites, and the key environmental factors of water availability and temperature. Interactions between these factors influence the dominance of fungi, particularly mycotoxigenic species. Studies have shown that growth, mycotoxin production, competitiveness and niche occupation by mycotoxigenic species are influenced by the presence of other contaminant moulds and environmental factors. This has been demonstrated for both Fusarium culmorum and deoxynivalenol production, Aspergillus ochraceus/Penicillium verruscosum and ochratoxin production and Fusarium section Liseola and fumonisin production. Interactions between mycotoxigenic spoilage fungi and insects do occur but have not been studied thoroughly. Some insects disseminate mycotoxigenic species, others are known to use spoilage moulds as a food source, while others avoid certain fungal species. Thus, a more holistic ecological view is needed when considering management approaches to long-term-safe storage of cereal grains after harvest.

Journal ArticleDOI
TL;DR: The concept of critical flux has been recognized as a convenient parameter for characterising fouling in membrane bioreactors (MBR), although it has recently been shown that membrane fouling takes place in this specific process under sub-critical operating conditions as mentioned in this paper.

Posted Content
TL;DR: In this paper, a structured approach to grounded theory-building is presented aimed at "mode 2" management researchers, in particular those who analyse recollections of past events, often recorded in interview data, to develop explanations of management action.
Abstract: This paper presents a structured approach to grounded theory-building. It is aimed at 'mode 2' (Gibbons et al., 1994) management researchers, in particular those who analyse recollections of past events, often recorded in interview data, to develop explanations of management action. Two characteristics of mode 2 enquiry - transdisciplinarity and an emphasis on tacit knowledge - make grounded theory potentially attractive to mode 2 researchers. However, the approach offered here differs in two important ways from the much-cited universal grounded theory model originated by Glaser and Strauss (1967) and later proceduralized by Strauss and Corbin (1990). First, it acknowledges that the form of theories of management action which will satisfy the contemporary demands of mode 2 research is different from the form of integrated sociological theory for which the original grounded theory approach was developed. Second, it takes account of differences between the ontological assumptions underlying the use of retrospective data for analysing management action, and those associated with participant observation, the pivotal strategy of grounded theory's symbolic interactionist roots. The result is a simplified, more direct approach which works for the specific purpose of generating useful, consensually valid theory.

Journal ArticleDOI
TL;DR: The authors discusses three particularly promising approaches (interactive discussion groups, self-reports, and practitioner-led research) that fit the increasingly disparate research paradigms now being used to understand strategizing and other management issues.
Abstract: Empirical studies of strategizing face contradictory pressures. Ethnographic approaches are attractive, and typically expected since we need to collect data on strategists and their practices within context. We argue, however, that today's large, multinational, and highly diversified organizational settings require complimentary methods providing more breadth and flexibility. This paper discusses three particularly promising approaches (interactive discussion groups, self-reports, and practitioner-led research) that fit the increasingly disparate research paradigms now being used to understand strategizing and other management issues. Each of these approaches is based on the idea that strategizing research cannot advance significantly without reconceptualizing frequently taken-for-granted assumptions about the way to do research and the way we engage with organizational participants. The paper focuses in particular on the importance of working with organizational members as research partners rather than passive informants.

Journal ArticleDOI
TL;DR: Raman spectroscopy appears to provide a highly sensitive and specific technique for the identification and classification of neoplasia in Barrett's oesophagus.
Abstract: Histopathology remains the gold standard technique for the diagnosis of intraepithelial neoplasia (dysplasia) in Barrett's oesophagus, but it is highly subjective and relies on blind biopsy targeting. The aim of this study was to evaluate Raman spectroscopy, a rapid, non-invasive, molecular, specific analytical technique, for the objective identification and classification of Barrett's neoplasia in vitro. A secondary objective was to demonstrate the need for a rigorous gold standard in the development of new diagnostic techniques. Forty-four patients with a mean age of 69 years (range 34–89 years) undergoing surveillance for Barrett's oesophagus were included in the study. Three consultant pathologists independently assessed snap-frozen oesophageal biopsy specimens. Raman spectra were measured on 87 histopathologically homogeneous samples. Spectral classification models were developed using multivariate analysis for the prediction of pathology. Histopathology and Raman classification results were compared. Raman spectral prediction with a consensus pathology classification model gave sensitivities between 73% and 100% and specificities of 90–100%. A high level of agreement (κ = 0.89) was demonstrated between the three-subset biopsy targeting model and consensus pathology opinion. This compares favourably with the agreement measured between an independent pathologist and the consensus pathology opinion for the same spectra (κ = 0.76). Raman spectroscopy appears to provide a highly sensitive and specific technique for the identification and classification of neoplasia in Barrett's oesophagus. Copyright © 2003 John Wiley & Sons, Ltd.

Journal ArticleDOI
TL;DR: In this paper, the authors have shown quantitatively how by measuring the soil microbial community, they can assess degradation and the effects of management designed to reverse it, and have shown that the size, composition and activity of soil microbial communities convincingly distinguish between systems, and between the impact of management strategies upon them.
Abstract: Summary Land degradation is of concern in many countries. In order for timely and effective interventions to be made to reverse this degradation it is necessary to have objective measurements of ecosystem status. By measuring characteristics of the soil microbial community we can assess the status of the microbial ecosystem and in that sense the quality of the soil, and the potential for, and progress of, restoration after degradation. Recent research has shown quantitatively how by measuring the soil microbial community we can assess degradation and the effects of management designed to reverse it. The size, composition and activity of the soil microbial community convincingly distinguish between systems, and between the impact of management strategies upon them. Measurements of these characteristics of the microbial community provide invaluable information for restoring degraded land and are ready for routine use. Specifically, profiles of phospholipid fatty acid contents, and substrate induced respiratory responses to different carbon substrates, will yield significant data upon which management decisions may be based.

Journal ArticleDOI
TL;DR: This study seeks to identify the dynamic capabilities that are necessary for e-business transformation and to identify practices in developing these capabilities that is both effective and common across companies, and might therefore be considered as ‘best practice’.
Abstract: The domain of e-business is characterised by rapid change and in such markets managers can no longer rely on the resources that they have assembled to provide their extant competitive position. Instead they must be able to combine resources in new ways, gain additional resources and dispose of superfluous resources, and to do this repeatedly and rapidly if they are to compete successfully. The term 'dynamic capabilities' is emerging in the strategic management literature for these skills. This study seeks to identify the dynamic capabilities that are necessary for e-business transformation and to identify practices in developing these capabilities that are both effective and common across companies, and might therefore be considered as 'best practice'. Eight distinct dynamic capabilities are identified, each appearing to address either innovative or integrative aspects of e-business transformation. Consistent with previous studies of dynamic markets it was found that 'best practice' involved simple, experiential and iterative approaches to these necessary capabilities.

Journal ArticleDOI
TL;DR: In this paper, the authors revisited theories that frame trust development in order to explore the development of trust in the specific social context of managerial relationships, and created a set of propositions that could inform further theory development and empirical investigation of the area.
Abstract: Despite significant theoretical work over the past decade, the phenomenon of trust and the process of its development in managerial relationships remain elusive in theory and practice. This paper revisits theories that frame trust development in order to explore the development of trust in the specific social context of managerial relationships. Managerial relationships are often characterised by politics and the pursuit of hidden agendas and self‐interest. Competing perspectives and personal motivations can conspire to render even the most innocent of acts subject to scrutiny and suspicion. In these senses, high levels of trust are not commensurate with ideal conditions for managerial effectiveness. Examines the realistic possibilities for trust development set in the context of managerial relationships, and in the process of this analysis, creates a set of propositions that could inform further theory development and empirical investigation of the area.

Journal ArticleDOI
TL;DR: The apparent poor performance of overland flow mitigation measures such as grass buffer strips in controlling the movement of faecal indicators highlights the need for a better understanding the dynamics of microbial transport so that better management approaches may be developed.
Abstract: Considerable investment has been made in recent years in improvements to the microbiological quality of urban wastewater discharges to surface waters, particularly in coastal towns, with the aim of reducing the exposure of bathers and surfers to gastrointestinal pathogens. As this source of pollution has come under greater control, attention has started to focus on diffuse catchment sources of faecal contamination which have been shown to be dominant during high river flows associated with storm events. This association with storm events suggests that rapidly responding hydrological pathways such as overland flow are likely to be important. The aim of this paper is to establish the current state of knowledge of pathogen transport processes in overland flow. In addition, the paper will attempt to convey the way that soil erosion science may aid our understanding of this environmental problem. The scale and nature of faecal waste applications to land in the UK is briefly reviewed, with data presented on both livestock slurry and manure, and human sewage sludge. Particular emphasis is placed on factors influencing the likelihood of pathogens making their way from infected livestock and humans to the soil surface, and therefore the chances of them being available for transport by overland flow. The literature relating to pathogen transport in overland flow is reviewed. Existing pathogen transport models treat pathogens as particles and link pathogen transport models to pathogen die-off kinetics. Such models do not attempt to describe the interactions that may occur between pathogens and soil and waste particles. Although conceptual models describing the possible states in which pathogen transport may occur have been proposed, an understanding of the factors controlling the partitioning of the microorganisms between the different states is only just beginning to emerge. The apparent poor performance of overland flow mitigation measures such as grass buffer strips in controlling the movement of faecal indicators highlights the need for a better understanding the dynamics of microbial transport so that better management approaches may be developed. Examples of on-going research into overland flow transport processes are briefly described and gaps in knowledge identified.

Journal ArticleDOI
TL;DR: An approach has been proposed to estimate the ecotoxicity of transformation products based on chemical structure and data on the toxicity of the parent compound to identify those substances that require further testing.
Abstract: Once released to the environment, pesticides may be degraded by abiotic and biotic processes. While parent compounds are assessed in detail in many regulatory schemes, the requirements for the assessment of transformation products are less well developed. This study was therefore performed to explore the relationships between the toxicity of transformation products and their parent compounds and to develop a pragmatic approach for use in the risk assessment of transformation products. Data were obtained on the properties and ecotoxicity of transformation products arising from a wide range of pesticides. Generally, transformation products were less toxic to fish, daphnids, and algae than their parent compound. In instances where a product was more toxic, the increase in toxicity could be explained by either (1) the presence of a pesticide toxicophore; (2) the fact that the product is the active part of a propesticide; (3) the product is accumulated to a greater extent than the parent compound; or (4) the product has a more potent mode of action than the parent. On the basis of the findings, an approach has been proposed to estimate the ecotoxicity of transformation products based on chemical structure and data on the toxicity of the parent compound. The assessments can be performed at an early stage in the risk assessment process to identify those substances that require further testing.

Proceedings ArticleDOI
E.J. Hughes1
08 Dec 2003
TL;DR: A new nonPareto evolutionary multiobjective algorithm, multiple single objective Pareto sampling (MSOPS), that performs a parallel search of multiple conventional target vector based optimisations, e.g. weighted min-max.
Abstract: We detail a new nonPareto evolutionary multiobjective algorithm, multiple single objective Pareto sampling (MSOPS), that performs a parallel search of multiple conventional target vector based optimisations, e.g. weighted min-max. The method can be used to generate the Pareto set and analyse problems with large numbers of objectives. The method allows bounds and discontinuities of the Pareto set to be identified and the shape of the surface to be analysed, despite not being able to visualise the surface easily. A new combination metric is also introduced that allows the shape of the objective surface that gives rise to discontinuities in the Pareto surface to be analysed easily.