Curtin University

About: Curtin University is a education organization based out in Perth, Western Australia, Australia. It is known for research contribution in the topics: Population & Zircon. The organization has 14257 authors who have published 48997 publications receiving 1336531 citations. The organization is also known as: WAIT & Western Australian Institute of Technology.

Australian undergraduates' use and ownership of emerging technologies: implications and opportunities for creating engaging learning experiences for the Net Generation

Abstract: Studies and commentary from the United States suggest that current undergraduates, part of the so called Net Generation, are high end users of emerging technologies such as mobile devices and new communication tools. This paper reports results from an Australian study of first year undergraduates which confirms these assertions: ownership of laptops, mobile phones and music devices appears to be growing rapidly among this group, along with their use of tools such as instant messaging, blogs and podcasts. Discussion of these results include suggestions as to how teachers of first year undergraduates can incorporate these tools and devices into extramural learning experiences in order to increase engagement and exploit the Net Generation's desire for 'connectedness'.

A simple model for squirt-flow dispersion and attenuation in fluid-saturated granular rocks.

Abstract: A major cause of seismic attenuation in fluid-saturated rocks is the flow of the pore fluid induced by the passing wave. At sonic and ultrasonic frequencies, attenuation appears to be dominated by the local (pore-scale) flow between pores of different shapes and orientations. A simple squirt flow model is developed in which all of the parameters can be independently measured or estimated from measurements. The pore space of the rock is assumed to consist of stiff porosity and compliant (or soft) pores present at grain contacts. The effect of isotropically distributed compliant pores is modeled by considering pressure relaxation in a disk-shaped gap between adjacent grains. This derivation gives the complex and frequency-dependent effective bulk and shear moduli of a rock, in which the compliant pores are liquid saturated and stiff pores are dry. The resulting squirt model is consistent with Gassmann’s and Mavko–Jizba equations at low and high frequencies, respectively. The magnitude of attenuation and dis...

A modification to the Goldstein radar interferogram filter

Abstract: We present a modification to the adaptive Goldstein radar interferogram filter which improves the quality of interferometry products. The proposed approach makes the Goldstein filter parameter alpha dependent on coherence, such that incoherent areas are filtered more than coherent areas. This modification minimizes loss of signal while still reducing the level of noise.

ABC Transporters in Cancer Stem Cells: Beyond Chemoresistance.

Abstract: The efficacy of chemotherapy is one of the main challenges in cancer treatment and one of the major obstacles to overcome in achieving lasting remission and a definitive cure in patients with cancer is the emergence of cancer resistance. Indeed, drug resistance is ultimately accountable for poor treatment outcomes and tumour relapse. There are various molecular mechanisms involved in multidrug resistance, such as the change in the activity of membrane transporters primarily belonging to the ATP binding cassette (ABC) transporter family. In addition, it has been proposed that this common feature could be attributed to a subpopulation of slow-cycling cancer stem cells (CSCs), endowed with enhanced tumorigenic potential and multidrug resistance. CSCs are characterized by the overexpression of specific surface markers that vary in different cancer cell types. Overexpression of ABC transporters has been reported in several cancers and more predominantly in CSCs. While the major focus on the role played by ABC transporters in cancer is polarized by their involvement in chemoresistance, emerging evidence supports a more active role of these proteins, in which they release specific bioactive molecules in the extracellular milieu. This review will outline our current understanding of the role played by ABC transporters in CSCs, how their expression is regulated and how they support the malignant metabolic phenotype. To summarize, we suggest that the increased expression of ABC transporters in CSCs may have precise functional roles and provide the opportunity to target, particularly these cells, by using specific ABC transporter inhibitors.

Climatic drivers of hemispheric asymmetry in global patterns of ant species richness

Abstract: Although many taxa show a latitudinal gradient in richness, the relationship between latitude and species richness is often asymmetrical between the northern and southern hemispheres. Here we examine the latitudinal pattern of species richness across 1003 local ant assemblages. We find latitudinal asymmetry, with southern hemisphere sites being more diverse than northern hemisphere sites. Most of this asymmetry could be explained statistically by differences in contemporary climate. Local ant species richness was positively associated with temperature, but negatively (although weakly) associated with temperature range and precipitation. After contemporary climate was accounted for, a modest difference in diversity between hemispheres persisted, suggesting that factors other than contemporary climate contributed to the hemispherical asymmetry. The most parsimonious explanation for this remaining asymmetry is that greater climate change since the Eocene in the northern than in the southern hemisphere has led to more extinctions in the northern hemisphere with consequent effects on local ant species richness.