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Institution

Curtin University

EducationPerth, Western Australia, Australia
About: Curtin University is a education organization based out in Perth, Western Australia, Australia. It is known for research contribution in the topics: Population & Zircon. The organization has 14257 authors who have published 48997 publications receiving 1336531 citations. The organization is also known as: WAIT & Western Australian Institute of Technology.


Papers
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Journal ArticleDOI
TL;DR: The current focus of this review is resveratrol’s in vivo and in vitro effects in a variety of cancers, and intracellular molecular targets modulated by this polyphenol.
Abstract: Natural product compounds have recently attracted significant attention from the scientific community for their potent effects against inflammation-driven diseases, including cancer. A significant amount of research, including preclinical, clinical, and epidemiological studies, has indicated that dietary consumption of polyphenols, found at high levels in cereals, pulses, vegetables, and fruits, may prevent the evolution of an array of diseases, including cancer. Cancer development is a carefully orchestrated progression where normal cells acquires mutations in their genetic makeup, which cause the cells to continuously grow, colonize, and metastasize to other organs such as the liver, lungs, colon, and brain. Compounds that modulate these oncogenic processes can be considered as potential anti-cancer agents that may ultimately make it to clinical application. Resveratrol, a natural stilbene and a non-flavonoid polyphenol, is a phytoestrogen that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. It has been reported that resveratrol can reverse multidrug resistance in cancer cells, and, when used in combination with clinically used drugs, it can sensitize cancer cells to standard chemotherapeutic agents. Several novel analogs of resveratrol have been developed with improved anti-cancer activity, bioavailability, and pharmacokinetic profile. The current focus of this review is resveratrol's in vivo and in vitro effects in a variety of cancers, and intracellular molecular targets modulated by this polyphenol. This is also accompanied by a comprehensive update of the various clinical trials that have demonstrated it to be a promising therapeutic and chemopreventive agent.

459 citations

Journal ArticleDOI
01 Jun 2006-Lithos
TL;DR: In this paper, a suite of A-type granites and mafic microgranular enclaves from the Early Cretaceous (126 −± 2 Ma) Qianshan pluton, Liaodong Peninsula, northeast China, were investigated.

459 citations

Journal ArticleDOI
TL;DR: A systematic review of the literature on predictors of complicated grief (CG) found perceived social support played a key role after death, along with cognitive appraisals and high distress at the time of the death.
Abstract: A systematic review of the literature on predictors of complicated grief (CG) was undertaken with the aim of clarifying the current knowledge and to inform future planning and work in CG following bereavement. Predictors of CG prior to the death include previous loss, exposure to trauma, a previous psychiatric history, attachment style, and the relationship to the deceased. Factors associated with the death include violent death, the quality of the caregiving or dying experience, close kinship relationship to the deceased, marital closeness and dependency, and lack of preparation for the death. Perceived social support played a key role after death, along with cognitive appraisals and high distress at the time of the death. Inconsistent definitions of CG and measurement tools were noted in the earlier studies reviewed. Limitations identified in the studies included use of cross-sectional designs, heterogeneous samples, high attrition, demographic differences between cases and controls, differences in length of time since death, and differences in types of death experienced. Notwithstanding these limitations, some consistent findings have emerged. Further research into conceptualizations of CG in terms of attachment theory and constructivist and cognitive-behavioral concepts of finding purpose and meaning after bereavement is warranted.

459 citations

Journal ArticleDOI
San Ping Jiang1
TL;DR: In this article, the advances and challenges in the development of nanoscale and nano-structured electrodes and the fundamental understanding of the remarkable enhancement in the electrode performance are reviewed and discussed with primary focus on the progress and status of the field in the last 5 years.

456 citations

Journal ArticleDOI
TL;DR: Using the Murchison Widefield Array (MWA), the low-frequency Square Kilometre Array precursor located in Western Australia, the authors have completed the GaLactic and Extragalactic All-sky MWA (GLEAM) survey.
Abstract: Using the Murchison Widefield Array (MWA), the low-frequency Square Kilometre Array precursor located in Western Australia, we have completed the GaLactic and Extragalactic All-sky MWA (GLEAM) survey, and present the resulting extragalactic catalogue, utilizing the first year of observations. The catalogue covers 24 831 square degrees, over declinations south of +30° and Galactic latitudes outside 10° of the Galactic plane, excluding some areas such as theMagellanic Clouds. It contains 307 455 radio sources with 20 separate flux density measurements across 72-231 MHz, selected from a time- and frequency-integrated image centred at 200 MHz, with a resolution of ≈2 arcmin. Over the catalogued region, we estimate that the catalogue is 90 per cent complete at 170 mJy, and 50 per cent complete at 55 mJy, and large areas are complete at even lower flux density levels. Its reliability is 99.97 per cent above the detection threshold of 5σ, which itself is typically 50 mJy. These observations constitute the widest fractional bandwidth and largest sky area survey at radio frequencies to date, and calibrate the low-frequency flux density scale of the southern sky to better than 10 per cent. This paper presents details of the flagging, imaging, mosaicking and source extraction/characterization, as well as estimates of the completeness and reliability. All source measurements and images are available online. 1 This is the first in a series of publications describing the GLEAM survey results.

455 citations


Authors

Showing all 14504 results

NameH-indexPapersCitations
David Smith1292184100917
Christopher G. Maher12894073131
Mike Wright12777564030
Shaobin Wang12687252463
Mietek Jaroniec12357179561
John B. Holcomb12073353760
Simon A. Wilde11839045547
Jian Liu117209073156
Meilin Liu11782752603
Guochun Zhao11340640886
Mark W. Chase11151950783
Robert U. Newton10975342527
Simon P. Driver10945546299
Peter R. Schofield10969350892
Gao Qing Lu10854653914
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202398
2022454
20214,200
20203,818
20193,822
20183,543