Institution
Danube University Krems
Education•Krems, Niederösterreich, Austria•
About: Danube University Krems is a education organization based out in Krems, Niederösterreich, Austria. It is known for research contribution in the topics: Stroke & Population. The organization has 498 authors who have published 1572 publications receiving 68797 citations.
Papers published on a yearly basis
Papers
More filters
••
TL;DR: This is the first meta-analysis of second-generation antidepressants to assess quantitatively all possible comparisons among drugs in this class and to determine whether efficacy, effectiveness, and harms differed among subgroups of patients on the basis of age, sex, race or ethnicity, or comorbid conditions.
Abstract: The authors reviewed the evidence of the benefits and harms of second-generation antidepressants for the treatment of depressive disorders in adults. They found that second-generation antidepressan...
221 citations
••
Princess Alexandra Hospital1, Utrecht University2, Nuffield Orthopaedic Centre3, Cedars-Sinai Medical Center4, National Institutes of Health5, University of California, San Francisco6, University of Texas Health Science Center at Houston7, Versailles Saint-Quentin-en-Yvelines University8, Sir Charles Gairdner Hospital9, University of Western Australia10, University of Oslo11, Oslo University Hospital12, National Institute for Health and Welfare13, King Abdulaziz University14, Danube University Krems15, Ghent University16, National Autonomous University of Mexico17, University of Otago18, Toronto Western Hospital19, Norfolk and Norwich University Hospital20, University of Cambridge21, University Health Network22, University of Toronto23, Memorial University of Newfoundland24, University of Alberta25, VU University Medical Center26, VU University Amsterdam27, Universidad de La Sabana28, Universidade Nova de Lisboa29, Spanish National Research Council30, University of Bristol31
TL;DR: In this article, the authors genotyped 7,264 MHC SNPs in 22,647 ankylosing spondylitis (AS) cases and controls of European descent.
Abstract: Ankylosing spondylitis (AS) is a common, highly heritable, inflammatory arthritis for which HLA-B*27 is the major genetic risk factor, although its role in the aetiology of AS remains elusive. To better understand the genetic basis of the MHC susceptibility loci, we genotyped 7,264 MHC SNPs in 22,647 AS cases and controls of European descent. We impute SNPs, classical HLA alleles and amino-acid residues within HLA proteins, and tested these for association to AS status. Here we show that in addition to effects due to HLA-B*27 alleles, several other HLA-B alleles also affect susceptibility. After controlling for the associated haplotypes in HLA-B, we observe independent associations with variants in the HLA-A, HLA-DPB1 and HLA-DRB1 loci. We also demonstrate that the ERAP1 SNP rs30187 association is not restricted only to carriers of HLA-B*27 but also found in HLA-B*40:01 carriers independently of HLA-B*27 genotype.
219 citations
••
TL;DR: It is shown that THP-1 differ from monocytes, PBMC, and whole blood with respect to cytokine release after stimulation with LPS, which supports the concept of extracorporeal mediator modulation as supportive therapy for sepsis.
Abstract: THP-1 cells are widely applied to mimic monocytes in cell culture models. In this study, we compared the cytokine release from THP-1, peripheral blood mononuclear cells (PBMC), monocytes, or whole blood after stimulation with lipopolysaccharide (LPS) and investigated the consequences of different cytokine profiles on human umbilical vein endothelial cell (HUVEC) activation. While Pseudomonas aeruginosa-stimulated (10 ng/mL) THP-1 secreted similar amounts of tumor necrosis factor alpha (TNF-α) as monocytes and PBMC, they produced lower amounts of interleukin(IL)-8 and no IL-6 and IL-10. Whole blood required a higher concentration of Pseudomonas aeruginosa (1000 ng/mL) to induce cytokine release than isolated monocytes or PBMC (10 ng/mL). HUVEC secreted more IL-6 and IL-8 after stimulation with conditioned medium derived from whole blood than from THP-1, despite equal concentrations of TNF-α in both media. Specific adsorption of TNF-α or selective cytokine adsorption from the conditioned media prior to HUVEC stimulation significantly reduced HUVEC activation. Our findings show that THP-1 differ from monocytes, PBMC, and whole blood with respect to cytokine release after stimulation with LPS. Additionally, we could demonstrate that adsorption of inflammatory mediators results in reduced endothelial activation, which supports the concept of extracorporeal mediator modulation as supportive therapy for sepsis.
216 citations
••
TL;DR: In comparison to other systems (for example, the Molecular Adsorbent Recirculating System [MARS] and albumin dialysis systems), the FPSA system enables much higher elimination of strongly bound albumin substances.
Abstract: The removal of albumin bound substances has gained increasing interest in different diseases, especially in acute and chronic liver disease. Therefore, a new system, the fractionated plasma separation and adsorption (FPSA) system, was developed based on combined membrane and adsorbent blood purification techniques. The most important contribution to the FPSA system was the development of a new polysulfone hollow-fiber filter, which is characterized by a sieving coefficient of 0.89 for human serum albumin (HSA) but only of 0.17 for fibrinogen, and 0 (zero) for IgM immunoglobulins. Using a closed filtrate circuit connected to the new polysulfone filter which integrates 1 or 2 adsorption columns and also a high flux dialyzer adapted to a dialysis machine, the FPSA system opens excellent possibilities for the relatively specific removal of albumin bound substances from the blood such as albumin bound bilirubin or even tryptophan. In comparison to other systems (for example, the Molecular Adsorbent Recirculating System [MARS] and albumin dialysis systems), the FPSA system enables much higher elimination of strongly bound albumin substances. The first clinical investigations have recently started based on a modified dialysis machine designed with all necessary safety measures.
216 citations
••
TL;DR: This paper coins a definition of ‘smart city governance’ and contributes to developing a framework for building new, smart governance models addressing the challenges of the digital society, collaborative governance, information sharing, citizen engagement, transparency and openness.
Abstract: This literature review has focused on smart governance as an emerging domain of study that attracts significant scientific and policy attention. More specifically, this paper aims to provide more insight in the definitions of and relationships between smart governance and concepts such as smart and electronic government, in the context of smart cities. The literature review shows that smart government can be considered as a basis for developing smart governance, through the application of emergent information and communication technologies (ICT) for governing. Smart governance as the intelligent use of ICT to improve decision-making through better collaboration among different stakeholders, including government and citizens, can be strongly related to government approaches. In this case ICT-based tools, such as social media, and openness can be factors that increase citizen engagement and support the development of new governance models for smart government. Smart governance may also have an important role in smart city initiatives, which require complex interactions between governments, citizens and other stakeholders. Based on the literature review, this paper coins a definition of ‘smart city governance’ and contributes to developing a framework for building new, smart governance models addressing the challenges of the digital society, collaborative governance, information sharing, citizen engagement, transparency and openness.
212 citations
Authors
Showing all 514 results
Name | H-index | Papers | Citations |
---|---|---|---|
Jaakko Tuomilehto | 115 | 1285 | 210682 |
Massimo Zeviani | 104 | 478 | 39743 |
J. Tuomilehto | 69 | 197 | 19801 |
Manfred Reichert | 67 | 695 | 19569 |
Roland W. Scholz | 64 | 289 | 15387 |
Michael Brainin | 55 | 215 | 44194 |
Gerald Gartlehner | 54 | 295 | 15320 |
Thomas Schrefl | 50 | 403 | 10867 |
Charity G. Moore | 50 | 179 | 11040 |
Josef Finsterer | 48 | 1479 | 13836 |
Silvia Miksch | 44 | 264 | 7790 |
J. Tuomilehto | 44 | 107 | 11425 |
Heinrich Schima | 43 | 249 | 5973 |
Reinhard Bauer | 40 | 228 | 5435 |
Thomas Groth | 38 | 186 | 5191 |