Danube University Krems

About: Danube University Krems is a education organization based out in Krems, Niederösterreich, Austria. It is known for research contribution in the topics: Stroke & Population. The organization has 498 authors who have published 1572 publications receiving 68797 citations.

Improving visual prognosis of the diabetic patients during the past 30 years based on the data of the Finnish Register of Visual Impairment.

Abstract: Purpose To evaluate changes in visual impairment (VI) due to diabetic retinopathy (DR) recorded in the Finnish Register of Visual Impairment (RVI) during the past 30 years. Methods Data from the visually impaired diabetic persons included in the RVI were analysed using three 10-year cohorts (1982–90, 1991–2000, 2001–10). Information on the age at the time of the first VI registration, severity of VI determined according to the World Health Organisation (WHO) definition, and the age at death was collected. VI due to proliferative (PDR) and non-proliferative (NPDR) DR were analysed separately. Results Data of 4080 patients whose primary cause for VI was DR were analysed. The median age at the time of notification of VI for the three cohorts was 39, 62 and 59 years in the PDR group and 71, 73 and 73 in the NPDR group, respectively. The proportion of blind persons was 42%, 22% and 15% in the PDR group and 10%, 9% and 4% in the NPDR group, respectively. The median age at death in the three cohorts was 54, 73 and 72 years in PDR group and 76, 79 and 80 years in the NPDR group, respectively. The standardized mortality ratio (SMR) compared with the general population was 8.3, 2.9 and 1.4 in persons with PDR and 3.4, 2.0 and 1.2 in those with NPDR, respectively. Conclusions A significant change in the profile of the VI in the PDR group has taken place in Finland. It was characterized by increased age at the time of VI notification, decreased severity of VI and higher age at death. Most evidently these improvements took place in the 1990s. The profile of VI in the NPDR group has changed only modestly. Compared with the general population, SMRs improved both in NPDR and PDR groups continuously.

The effects of control of systolic and diastolic hypertension on cardiovascular and all-cause mortality in a community-based population cohort

Abstract: The objective of this study (follow-up of 26 113 people) was to investigate differences in the risk of cardiovascular disease (CVD) and all-cause mortality among hypertensive people according to the control of systolic blood pressure (SBP) and diastolic blood pressure (DBP). People with a history of coronary heart disease, heart failure, cancer or incomplete data at baseline (n=1113) were excluded from the study. The participants were classified into six groups according to their blood pressure status. Treated hypertensive individuals with controlled SBP and DBP did not experience an increase in all-cause mortality compared with normotensive people. The increase in all-cause mortality was 1.48-fold (95% confidence interval (CI) 1.09–2.01) among those who were treated with antihypertensive drugs and had only their DBP controlled and 1.45-fold (95% CI 1.04–2.02) among those who were treated and had only their SBP controlled. Treated patients with both SBP and DBP controlled did not have an increased risk of CVD mortality when compared with normotensive people. The risk of CVD mortality was statistically significantly higher in treated hypertensive people with SBP alone, DBP alone or both SBP and DBP uncontrolled. Our study indicates that uncontrolled SBP alone and DBP alone are risk factors of all-cause and CVD mortality.

Histological Analysis of Cartilage Defects Repaired with an Autologous Human Stem Cell Construct 48 Weeks Postimplantation Reveals Structural Details Not Detected by T2-Mapping MRI.

Abstract: ObjectiveThe aim of this study was to elucidate the efficacy of T2-mapping MRI and correlation with histology for the evaluation of tissue repair quality following the first-in-human implantation o...

Resonance parameter estimation from spectral data: Cramér–Rao lower bound and stable algorithms with application to liquid sensors

Abstract: A recently introduced method for robust determination of the parameters of strongly damped resonances is evaluated in terms of achievable accuracy. The method extracts and analyzes the locus of the resonant subsystem of noisy recorded complex spectra, such that the interfering influences of many environmental factors are eliminated. Estimator performance is compared to the absolute lower limit determining the Cramer–Rao lower bound (CRLB) for the variance of the estimated parameters. A generic model that is suitable for representation of a large class of sensors is used and analyzed. It is shown that the proposed robust method converges to the CRLB for low measurement noise.

TYDR - Track Your Daily Routine. Android App for Tracking Smartphone Sensor and Usage Data

Abstract: We present the Android app TYDR (Track Your Daily Routine) which tracks smartphone sensor and usage data and utilizes standardized psychometric personality questionnaires. With the app, we aim at collecting data for researching correlations between the tracked smartphone data and the user's personality in order to predict personality from smartphone data. In this paper, we highlight our approaches in addressing the challenges in developing such an app. We optimize the tracking of sensor data by assessing the trade-off of size of data and battery consumption and granularity of the stored information. Our user interface is designed to incentivize users to install the app and fill out questionnaires. TYDR processes and visualizes the tracked sensor and usage data as well as the results of the personality questionnaires. When developing an app that will be used in psychological studies, requirements posed by ethics commissions / institutional review boards and data protection officials have to be met. We detail our approaches concerning those requirements regarding the anonymized storing of user data, informing the users about the data collection, and enabling an opt-out option. We present our process for anonymized data storing while still being able to identify individual users who successfully completed a psychological study with the app.