Danube University Krems

About: Danube University Krems is a education organization based out in Krems, Niederösterreich, Austria. It is known for research contribution in the topics: Stroke & Population. The organization has 498 authors who have published 1572 publications receiving 68797 citations.

EFNS guidelines on the molecular diagnosis of channelopathies, epilepsies, migraine, stroke, and dementias.

Abstract: Objectives: These EFNS guidelines on the molecular diagnosis of channelopathies, including epilepsy and migraine, as well as stroke, and dementia are designed to summarize the possibilities and limitations of molecular genetic techniques and to provide diagnostic criteria for deciding when a molecular diagnostic work-up is indicated Search strategy: To collect data about planning, conditions, and performance of molecular diagnosis of these disorders, a literature search in various electronic databases was carried out and original papers, meta-analyses, review papers, and guideline recommendations were reviewed Results: The best level of evidence for genetic testing recommendation (B) can be found for a small number of syndromes, cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy, severe myoclonic epilepsy of infancy, familial recurrent hemorrhages, familial Alzheimer’s disease, and frontotemporal lobar degeneration Good practice points can be formulated for a number of other disorders Conclusion: These guidelines are provisional, and the future availability of molecular genetic epidemiological data about the neurogenetic disorders under discussion in our article will allow improved recommendation with an increased level of evidence

The Evolving e-Governance Curriculum: A Worldwide mapping of Education Programs

Abstract: From the demand side, the need to build e-Governance capacities and expertise is increasing and requires more and more sophisticated knowledge and competencies to fulfil the stakeholders' needs. The e-Governance profession and skills needs are also becoming more diverse and more specialized. From the supply side, we can also witness a growing interest in the e-Governance learning and programs worldwide at different level. However the programs offered are often not well aligned adapting neither to the government's, nor to the public service needs. The e-Governance curriculum is a key success factor to reduce the gap. It serves as a base of knowledge for a large number of graduates that participate in government digital transformation activities. Within academic and practitioners' communities, there have been constant discussions about the content of the e-Governance curriculum. The objective of this research is to identify and analyse the current situation in e-Governance training worldwide and provide a path forward for future e-Governance program relative curriculum development. For this purpose, the authors applied a systematic secondary data review method to examine the existing e-Governance programs and draw an e-Governance education mapping worldwide. The research establishes the current baseline of e-Governance curricula and describes their fundamental aspects and challenges. Information provided in this article should be valuable to the e-Governance educators and curriculum designers, as well as to the e-Governance practitioners, to better understand the foundational knowledge transmitted to e-Governance graduates.

Thermal actuators featuring large displacements for passive temperature sensing

Abstract: The thermal actuator presented in this paper consists of two symmetrically V-shaped beam stacks, where each stack consists of six beams in parallel. The stacks are coupled facing each other and slightly shifted along the mirror axis. Both stacks are connected to a lever beam and fixed at four anchor regions to the substrate. Due to the difference in the coefficient of thermal expansion of the material of the beams and the one of the substrate, the tip of the lever moves perpendicular to the mirror axis. The device is fabricated from galvanic deposited nickel on a silicon substrate. Finite element simulations were carried out to optimize the design with respect to the sensitivity and the maximum mechanical stress. The stress needs to be lower than the yield strength of the material. Otherwise, plastic deformations of the beams would lead to irreversible deflections of the beam tip. This limits the overall sensitivity of the design. First results of the device with 400 μm long bent beams show a linear behavior and a sensitivity of 0.5 μm/K and forces of 66 μN/K for a temperature range of ź30 °C up to +40 °C.