Institution
Danube University Krems
Education•Krems, Niederösterreich, Austria•
About: Danube University Krems is a education organization based out in Krems, Niederösterreich, Austria. It is known for research contribution in the topics: Stroke & Population. The organization has 498 authors who have published 1572 publications receiving 68797 citations.
Papers published on a yearly basis
Papers
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TL;DR: Though the L230I mutation seems to play a causative role for dCMP, prospective studies on yeast or transgenic mice models with defined mutation are warranted to study the pathogenetic impact of this mutation.
Abstract: Background. Previously it has been shown that various types of hypertrophic and dilative cardiomyopathy (hCMP, dCMP) can be attributed to disturbed mitochondrial oxidative energy metabolism. Several studies described mutations in mitochondrial DNA-located genes encoding for subunits of respiratory chain complexes, including the cytochrome b gene (MT-CYB), causing CMPs. Methods and Results. In the present study the MT-CYB gene was analysed in 30 patients with hCMP, 40 patients with dCMP, and 50 controls for alterations. Altogether, 27 MT-CYB variants were detected. Twenty-four of them were single nucleotide polymorphisms defining common haplogroups. The variant m.15434C>A was found in a single patient with severe dCMP and assessed as novel mutation, since it was not found in healthy controls or available data sets, and was nonhaplogroup associated with Phylotree. This variant altered an amino acid (L230I) with a high interspecific amino acid conservation index (CI = 97.7%) indicative of the functional importance of the residue. Conclusions. Though the L230I mutation seems to play a causative role for dCMP, prospective studies on yeast or transgenic mice models with defined mutation are warranted to study the pathogenetic impact of this mutation.
9 citations
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TL;DR: Metabonomics identifies early molecular changes associated with progression into postoperative hypoxemia in cardiac surgery patient: a human model that can provide new insights into the pathophysiology of acute lung injury and potentially identify specific biomarkers of lung tissue injury.
Abstract: Citation for published version (APA): Rasmussen, B. S., Maltesen, R., Hanifa, M., Pedersen, S., Kristensen, S. R., & Wimmer, R. (2016). Metabonomics identifies early molecular changes associated with progression into postoperative hypoxemia in cardiac surgery patient: a human model that can provide new insights into the pathophysiology of acute lung injury and potentially identify specific biomarkers of lung tissue injury. Intensive Care Medicine Experimental, 4(Suppl. 1), 13. [A22]. https://doi.org/10.1186/s40635-016-0098-x
9 citations
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TL;DR: This first pilot study clearly shows that water/air cooling in vitro has an effect on collateral tissue damage and reduction of collateral thermal damage after diode laser incisions is clinically relevant for promoted wound healing.
Abstract: Since the diode laser is a good compromise for the daily use in dental offices, finding usage in numerous dental indications (e.g., surgery, periodontics, and end- odontics), the minimization of the collateral damage in laser surgery is important to improve the therapeutical outcome. The aim of this study was to investigate the effect of water/air cooling on the collateral thermal soft tissue damage of 980-nm diode laser incisions. A total of 36 mechanically executed laser cuts in pork liver were made with a 980-nm diode laser in micropulsed mode with three different settings of water/air cooling and examined by histological assessment to determine the area and size of carbonization, necrosis, and reversible tissue damage as well as incision depth and width. In our study, clearly the incision depth increased significantly under water/air cooling (270.9 versus 502.3 μm—test group 3) without significant changes of incision width. In test group 2, the total area of damage was significantly smaller than in the control group (in this group, the incision depth increases by 65 %). In test group 3, the total area of damage was significantly higher (incision depth increased by 85 %), but the bigger part of it represented a reversible tissue alteration leaving the amount of irreversible damage almost the same as in the control group. This first pilot study clearly shows that water/air cooling in vitro has an effect on collateral tissue damage. Further studies will have to verify, if the reduced collateral damage we have proved in this study can lead to accelerated wound healing. Re- duction of collateral thermal damage after diode laser incisions is clinically relevant for promoted wound healing.
9 citations
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05 Jun 2019
TL;DR: An architectural design for managing geospatial data of tinnitus patients is proposed, which combines a cloudnative approach with Big Data concepts used in the Internet of Things and a visualization feature is presented to provide users with a comprehensive overview of noise levels in their environment based on noise measurements.
Abstract: Smart devices and low-powered sensors are becoming increasingly ubiquitous and nowadays almost all of these devices are connected, which is a promising foundation for crowdsensing of data related to various environmental phenomena. Resulting data is especially meaningful when it is related to time and location. Interestingly, many existing approaches built their solution on monolithic backends that process data on a per-request basis. However, for many scenarios, such technical setting is not suitable for managing data requests of a large crowd. For example, when dealing with millions of data points, still many challenges arise for modern smartphones if calculations or advanced visualization features must be accomplished directly on the smartphone. Therefore, the work at hand proposes an architectural design for managing geospatial data of tinnitus patients, which combines a cloudnative approach with Big Data concepts used in the Internet of Things. The presented architectural design shall serve as a generic foundation to implement (1) a scalable backend for a platform that covers the aforementioned crowdsensing requirements as well as to provide (2) a sophisticated stream processing concept to calculate and pre-aggregate incoming measurement data of tinnitus patients. Following this, this paper presents a visualization feature to provide users with a comprehensive overview of noise levels in their environment based on noise measurements. This shall help tinnitus or hearing-impaired patients to avoid locations with a burdensome sound level.
9 citations
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TL;DR: In this paper, a layer-by-layer arrangement of polymers and nanocomposites is used as a new electrode sensing material for rapid and direct electrochemical determination of uric acid (UA).
9 citations
Authors
Showing all 514 results
Name | H-index | Papers | Citations |
---|---|---|---|
Jaakko Tuomilehto | 115 | 1285 | 210682 |
Massimo Zeviani | 104 | 478 | 39743 |
J. Tuomilehto | 69 | 197 | 19801 |
Manfred Reichert | 67 | 695 | 19569 |
Roland W. Scholz | 64 | 289 | 15387 |
Michael Brainin | 55 | 215 | 44194 |
Gerald Gartlehner | 54 | 295 | 15320 |
Thomas Schrefl | 50 | 403 | 10867 |
Charity G. Moore | 50 | 179 | 11040 |
Josef Finsterer | 48 | 1479 | 13836 |
Silvia Miksch | 44 | 264 | 7790 |
J. Tuomilehto | 44 | 107 | 11425 |
Heinrich Schima | 43 | 249 | 5973 |
Reinhard Bauer | 40 | 228 | 5435 |
Thomas Groth | 38 | 186 | 5191 |