Danube University Krems

About: Danube University Krems is a education organization based out in Krems, Niederösterreich, Austria. It is known for research contribution in the topics: Stroke & Population. The organization has 498 authors who have published 1572 publications receiving 68797 citations.

Release kinetics and mitogenic capacity of collagen barrier membranes supplemented with secretome of activated platelets - the in vitro response of fibroblasts of the periodontal ligament and the gingiva

Abstract: Background Platelet preparations can stimulate the healing process and have mitogenic properties. We hypothesized that collagen barrier membranes (CBM), clinically used in guided bone regeneration and guided tissue regeneration, can serve as carriers for platelet secretome. Methods Secretome was generated from washed platelets and unwashed platelets (washed/unwashed PSEC) and lyophilized onto CBM. Overall appearance of CBM was evaluated by scanning electron microscopy. The impact of PSEC on cell attachment was measured based on fluorescence microscopy with DiI-labeled cells. To assess the release kinetics, supernatants of CBM were collected and medium was replaced at hour 1–48. The mitogenic effect was evaluated with periodontal fibroblasts. Furthermore, the release of total protein, platelet-derived growth factor (PDGF)-BB, and transforming growth factor (TGF) β1 was measured. Results CBM overall appearance and cell attachment was not modulated by PSEC. Supernatants taken after one hour induced a mitogenic response in fibroblasts and showed the highest levels of total protein, TGFβ1 and PDGF-BB. These effects decreased rapidly in subsequent supernatants. While supernatants of CBM loaded with unwashed PSEC induced a stronger mitogenic response than supernatants of CBM loaded with washed PSEC this difference between the PSEC preparations was not observed when cells were seeded on 48–hours-washed CBM. Conclusions CBM release platelet-derived factors in continuously declining release kinetics.

Patterns of Use: How Older Adults with Progressed Dementia Interact with a Robot

Abstract: Older adults represent a new user group of robots that are deployed in their private homes or in care facilities. In the presented study tangible aspects of older adults' interaction with an autonomous robot were focused. The robot was deployed as a companion in physical therapy for older adults with progressed dementia. Interaction was possible via a mounted touch screen. The menu was structured in a single layer and icons were big and with strong contrast. Employing a detailed observation protocol, interaction frequencies and contexts were assessed. Thereby, it was found that most of the interaction was encouraged by the therapists and two out of 12 older adults with progressed dementia showed self-inducted interactions.

MOEMS transducer with a non-linear transfer characteristic for static displacement measurement applications on the example of an inclination sensor

Abstract: This contribution describes an micro-opto-electro-mechanical system transducer with a well defined inherent non-linear transfer behavior and its impact on the quantification of static and dynamic displacements in a vibrating measurement mode The transducer’s output signal is proportional to a light-flux that is modulated by two overlapping aperture arrays One of these arrays is deposited on a fixed glass cover while the other one is etched into a moveable seismic mass of a silicon micro-electro-mechanical chip The non-linear transfer characteristic is achieved by pairing triangularly shaped apertures with rectangular ones The seismic mass is actuated by a mechanical shaker unit and the resulting first and second harmonics of the output signal are recorded with lock-in amplifiers These harmonics contain information about both the static displacement and the vibration amplitude of the seismic mass The presented method was tested with a proof-of-concept device and first measurement results exhibit a static displacement resolution of 367 nm which is a slight improvement compared to DC measurement approaches exhibiting a resolution of 539 nm Furthermore, a inclination sensor was built employing this vibrating measurement approach showing that the resolution was improved at least by an factor of three