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Institution

Danube University Krems

EducationKrems, Niederösterreich, Austria
About: Danube University Krems is a education organization based out in Krems, Niederösterreich, Austria. It is known for research contribution in the topics: Stroke & Population. The organization has 498 authors who have published 1572 publications receiving 68797 citations.


Papers
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Journal ArticleDOI
TL;DR: It is concluded that small animal models may be sufficient to investigate degradation rates and provide preliminary evidence on bone formation and in-growth of implant materials in a growing-animal model.

43 citations

Journal ArticleDOI
TL;DR: In this article, a micromagnetic model for the bilayer system is presented, where the microstructural features of both layers are incorporated to investigate the magnetization reversal behavior of such media.
Abstract: Ferri-/ferromagnetic exchange coupled composites are promising candidates for bit patterned media because of the ability to control the magnetic properties of the ferrimagnet by its composition. A micromagnetic model for the bilayer system is presented where we also incorporate the microstructural features of both layers. Micromagnetic finite element simulations are performed to investigate the magnetization reversal behaviour of such media. By adding the exchange coupled ferrimagnet to the ferromagnet, the switching field could be reduced by up to 40% and also the switching field distribution is narrowed. To reach these significant improvements, an interface exchange coupling strength of 2 mJ/m2 is required.

43 citations

Journal ArticleDOI
TL;DR: This work proposes a three-level methodology to make more out of users' insights in the field of visual analytics, and helps to understand how insights emerge and build on one each other.
Abstract: For evaluating visual-analytics tools, many studies confine to scoring user insights into data. For participatory design of those tools, we propose a three-level methodology to make more out of users' insights. The relational insight organizer (RIO) helps to understand how insights emerge and build on one each other. In recent years, computers have also been used to develop visual methods and tools that further support the data analysis process. With the advent of the emerging field of visual analytics (VA), the underlying concept of visual tools is taken a step further. In essence, VA combines human analytical capabilities with computer processing capacities. In the human-computer interaction process, the user generates new knowledge and gains insights.

43 citations

Journal ArticleDOI
TL;DR: This study emphasises the importance of preventive interventions in people with prediabetes and indicates no differences of beneficial preventive effects on the incidence of type 2 diabetes and weight gain between men and women.
Abstract: Aims/hypothesis In people with prediabetes, lifestyle interventions and glucose-lowering medications are effective in preventing the progression to type 2 diabetes. It is unclear whether differences in treatment effects between men and women need to be taken into consideration when choosing a preventive strategy for an individual person.

43 citations

Journal ArticleDOI
TL;DR: Tailored, multimodal therapies may be required to reduce the risk of cognitive dysfunction and decline in patients with DM and the use of pleiotropic drugs with multi-modal mechanisms of action may have a role in the treatment of Cognitive dysfunction and their use may warrant further investigation in diabetic populations.
Abstract: Diabetes mellitus (DM) is associated with an increased risk of mild cognitive impairment, dementia and stroke. The association between DM and dementia appears to be stronger for vascular cognitive impairment than for Alzheimer’s disease, suggesting cerebrovascular disease may be an important factor in cognitive impairment in DM. Although the exact mechanisms by which DM affects the brain remain unclear, changes to brain vasculature, disturbances of cerebral insulin signaling, insulin resistance, glucose toxicity, oxidative stress, accumulation of advanced glycation end products, hypoglycemic episodes, and alterations in amyloid metabolism may all be involved. Cognitive impairment and dementia associated with DM may also be mediated via vascular risk factors, in particular brain ischemia, the occurrence of which can have an additive or synergistic effect with concomitant neurodegenerative processes. To date, no drug has been approved for the treatment of vascular dementia and there are no specific pharmacological treatments for preventing or reducing cognitive decline in patients with DM. Most focus has been on tighter management of vascular risk factors, although evidence of reduced cognitive decline through reducing blood pressure, lipid-lowering or tighter glycemic control is inconclusive. Tailored, multimodal therapies may be required to reduce the risk of cognitive dysfunction and decline in patients with DM. The use of pleiotropic drugs with multimodal mechanisms of action (e.g., cerebrolysin, Actovegin) may have a role in the treatment of cognitive dysfunction and their use may warrant further investigation in diabetic populations.

43 citations


Authors

Showing all 514 results

NameH-indexPapersCitations
Jaakko Tuomilehto1151285210682
Massimo Zeviani10447839743
J. Tuomilehto6919719801
Manfred Reichert6769519569
Roland W. Scholz6428915387
Michael Brainin5521544194
Gerald Gartlehner5429515320
Thomas Schrefl5040310867
Charity G. Moore5017911040
Josef Finsterer48147913836
Silvia Miksch442647790
J. Tuomilehto4410711425
Heinrich Schima432495973
Reinhard Bauer402285435
Thomas Groth381865191
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
20237
202221
2021176
2020165
2019157
2018144