Institution
Danube University Krems
Education•Krems, Niederösterreich, Austria•
About: Danube University Krems is a education organization based out in Krems, Niederösterreich, Austria. It is known for research contribution in the topics: Stroke & Population. The organization has 498 authors who have published 1572 publications receiving 68797 citations.
Papers published on a yearly basis
Papers
More filters
••
TL;DR: In this paper, the authors compute maps of the local nucleation field in a Nd2Fe14B permanent magnet using a model order reduction approach and quantify the reduction of the coercive field due to thermal activation.
27 citations
••
18 Jun 2018
TL;DR: More evaluations are necessary for TrackYourTinnitus in particular and mHealth technology in general to understand how smartphones affect the gathering of data on chronic diseases when using them in the large.
Abstract: Presently, mHealth technology is often applied in the context of chronic diseases to gather data that may lead to new and valuable medical insights. As many aspects of chronic diseases are not completely understood, new data sources might be promising. mHealth technology may help in this context as it can be easily used in everyday life. Moreover, the bring your own device principle encourages many patients to use their smartphone to learn more about their disease. The less is known about a disorder (e.g., tinnitus), the more patients crave for new insights and opportunities. Despite the fact that existing mHealth technology like mobile crowdsensing has already gathered data that may help patients, in general, less is known whether and how data gathered with different mobile technologies may differ. In this context, one relevant aspect is the contribution of the mobile operating system itself. For example, are there differences between Android and iOS users that utilize the same mHealth technology for a disease. In the TrackYourTinnitus project, a mobile crowdsensing mHealth platform was developed to gather data for tinnitus patients in order to reveal new insights on this disorder with high economic and patient-related burdens. As many data sets were gathered during the last years that enable us to compare Android and iOS users, the work at hand compares characteristics of these users. Interesting insights like the one that Android users with tinnitus are significantly older than iOS users could be revealed by our study. However, more evaluations are necessary for TrackYourTinnitus in particular and mHealth technology in general to understand how smartphones affect the gathering of data on chronic diseases when using them in the large.
27 citations
••
TL;DR: An algorithm for optimized citrate anticoagulation in extracorporeal therapies such as dialysis is developed that adapts well to variable treatment parameters and shows an excellent fit to the laboratory measurements.
Abstract: Background: Citrate anticoagulation offers several advantages in comparison to conventional anticoagulation. Most algorithms for regional citrate-calcium anticoagulation are based on citrate and calcium chloride infusion coupled in a fixed proportion to the blood flow without considering the hematocrit (Hct)/plasma flow or the filter clearance of citrate and calcium. Methods: The aim of this study was to develop an algorithm for optimized citrate anticoagulation in extracorporeal therapies such as dialysis. A mathematical model was developed to calculate the volume of citrate infusion required to achieve a desired ionized calcium (iCa) target level in the extracorporeal circuit and to restore the total calcium level to a physiological value. Results: The model was validated by correlation analyses for different blood Hct values and shows an excellent fit to the laboratory measurements. Conclusion: The results for both iCa target concentrations, namely those after citrate and calcium infusion, proved that the software algorithm adapts well to variable treatment parameters.
27 citations
••
TL;DR: None of the adsorbents that were tested showed promising results for potential use in extracorporeal blood purification, but DEAE-Sepharose was most effective in LPS adsorption.
Abstract: IntroductionLipopolysaccharides (LPS) are extremely strong stimulators of inflammatory reactions, act at very low concentrations, and are involved in the pathogenesis of sepsis and septic shock. Be...
27 citations
••
TL;DR: The cell culture model established in this study permits the monitoring of LPS-induced endothelial activation, which plays a central role in sepsis and may serve to assess the effect of mediator modulation by methods such as extracorporeal blood purification.
Abstract: The aim of this work was to establish and characterize a cell culture model for lipopolysaccharide (LPS)-induced activation of human endothelial cells Monocytic THP-1 cells were stimulated for 4 h with 10 ng/ml LPS from Pseudomonas aeruginosa in media containing 10% human plasma Culture supernatants containing LPS and factors secreted by THP-1 in response to stimulation were applied to human umbilical vein endothelial cells (HUVECs) Nuclear factor-κB (NF-κB) activity, expression of adhesion molecules, and cytokine secretion were quantified In addition, the effect of adsorptive removal of tumour necrosis factor-α (TNF-α) from the THP-1 culture supernatant on HUVEC activation was assessed After 4 h of stimulation, THP-1 cells secreted various mediators including TNF-α (854 ± 472 pg/ml), interleukin (IL)-8 (2069 ± 710 pg/ml), IL-18 (305 ± 124 pg/ml), IL-10 (14 ± 5 pg/ml), and IL-1β (24 ± 11 pg/ml) Stimulated HUVECs showed significantly increased NF-κB activity and secreted high amounts of IL-6 and IL-8 Additionally, adhesion molecules ICAM-1 and E-selectin were increased both in the culture supernatant and at the cell surface Removal of TNF-α from the THP-1 culture supernatant prior to HUVEC stimulation resulted in a decrease in NF-κB activity, expression of adhesion molecules, as well as IL-6 secretion The cell culture model established in this study permits the monitoring of LPS-induced endothelial activation, which plays a central role in sepsis and may serve to assess the effect of mediator modulation by methods such as extracorporeal blood purification
27 citations
Authors
Showing all 514 results
Name | H-index | Papers | Citations |
---|---|---|---|
Jaakko Tuomilehto | 115 | 1285 | 210682 |
Massimo Zeviani | 104 | 478 | 39743 |
J. Tuomilehto | 69 | 197 | 19801 |
Manfred Reichert | 67 | 695 | 19569 |
Roland W. Scholz | 64 | 289 | 15387 |
Michael Brainin | 55 | 215 | 44194 |
Gerald Gartlehner | 54 | 295 | 15320 |
Thomas Schrefl | 50 | 403 | 10867 |
Charity G. Moore | 50 | 179 | 11040 |
Josef Finsterer | 48 | 1479 | 13836 |
Silvia Miksch | 44 | 264 | 7790 |
J. Tuomilehto | 44 | 107 | 11425 |
Heinrich Schima | 43 | 249 | 5973 |
Reinhard Bauer | 40 | 228 | 5435 |
Thomas Groth | 38 | 186 | 5191 |