Institution
Deakin University
Education•Burwood, Victoria, Australia•
About: Deakin University is a education organization based out in Burwood, Victoria, Australia. It is known for research contribution in the topics: Population & Context (language use). The organization has 12118 authors who have published 46470 publications receiving 1188841 citations. The organization is also known as: Deakin.
Papers published on a yearly basis
Papers
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TL;DR: Current knowledge of the neuroprogressive processes that may occur in MDD is reviewed, including structural brain consequences and potential molecular mechanisms including the role of neurotransmitter systems, inflammatory, oxidative and nitrosative stress pathways, neurotrophins and regulation of neurogenesis, cortisol and the hypothalamic–pituitary–adrenal axis modulation.
Abstract: In some patients with major depressive disorder (MDD), individual illness characteristics appear consistent with those of a neuroprogressive illness. Features of neuroprogression include poorer symptomatic, treatment and functional outcomes in patients with earlier disease onset and increased number and length of depressive episodes. In such patients, longer and more frequent depressive episodes appear to increase vulnerability for further episodes, precipitating an accelerating and progressive illness course leading to functional decline. Evidence from clinical, biochemical and neuroimaging studies appear to support this model and are informing novel therapeutic approaches. This paper reviews current knowledge of the neuroprogressive processes that may occur in MDD, including structural brain consequences and potential molecular mechanisms including the role of neurotransmitter systems, inflammatory, oxidative and nitrosative stress pathways, neurotrophins and regulation of neurogenesis, cortisol and the hypothalamic–pituitary–adrenal axis modulation, mitochondrial dysfunction and epigenetic and dietary influences. Evidence-based novel treatments informed by this knowledge are discussed.
443 citations
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TL;DR: Population strategies addressing the metabolic syndrome should focus on reducing sedentary behaviours such as TV viewing, as well as increasing physical activity, while physical activity was associated with a reduced prevalence.
Abstract: Aims/hypothesis
We analysed a sample of Australian adults to determine the strength of associations of TV viewing and participation in physical activity with the metabolic syndrome.
443 citations
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TL;DR: Experimental, clinical and epidemiological observations in neurodegenerative disorders like Alzheimer's disease and in the genetically inherited copper-dependent disorders Menkes and Wilson disease are summarized to provide a rationale for a link between severely dysregulated metal-ion homeostasis and the selective neuronal pathology.
439 citations
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TL;DR: Significant, detrimental dose-response associations of television-viewing time were observed with waist circumference, systolic blood pressure, and 2-h plasma glucose in men and women, and with fasting plasma glucose, triglycerides, and HDL-C in women.
Abstract: Purpose:Among Australian adults who met the public health guideline for the minimum health-enhancing levels of physical activity, we examined the dose-response associations of television-viewing time with continuous metabolic risk variables.Methods:Data were analyzed on 2031 men and 2033 wom
439 citations
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TL;DR: There is evidence of a significant, cross-sectional relationship between unhealthy dietary patterns and poorer mental health in children and adolescents and a consistent trend for the relationship between good-quality diet and better mental health and some evidence for the reverse.
Abstract: We systematically reviewed 12 epidemiological studies to determine whether an association exists between diet quality and patterns and mental health in children and adolescents; 9 explored the relationship using diet as the exposure, and 3 used mental health as the exposure. We found evidence of a significant, cross-sectional relationship between unhealthy dietary patterns and poorer mental health in children and adolescents. We observed a consistent trend for the relationship between good-quality diet and better mental health and some evidence for the reverse. When including only the 7 studies deemed to be of high methodological quality, all but 1 of these trends remained. Findings highlight the potential importance of the relationship between dietary patterns or quality and mental health early in the life span.
439 citations
Authors
Showing all 12448 results
Name | H-index | Papers | Citations |
---|---|---|---|
Patrick D. McGorry | 137 | 1097 | 72092 |
Mary Story | 135 | 522 | 64623 |
Dacheng Tao | 133 | 1362 | 68263 |
Paul Harrison | 133 | 1400 | 80539 |
Paul Zimmet | 128 | 740 | 140376 |
Neville Owen | 127 | 700 | 74166 |
Louisa Degenhardt | 126 | 798 | 139683 |
David Scott | 124 | 1561 | 82554 |
Anthony F. Jorm | 124 | 798 | 67120 |
Tao Zhang | 123 | 2772 | 83866 |
John C. Wingfield | 122 | 509 | 52291 |
John J. McGrath | 120 | 791 | 124804 |
Eduard Vieta | 119 | 1248 | 57755 |
Michael Berk | 116 | 1284 | 57743 |
Ashley I. Bush | 116 | 560 | 57009 |