Deakin University

About: Deakin University is a education organization based out in Burwood, Victoria, Australia. It is known for research contribution in the topics: Population & Context (language use). The organization has 12118 authors who have published 46470 publications receiving 1188841 citations. The organization is also known as: Deakin.

Life-cycle energy analysis of buildings: a case study

Abstract: Energy use is a widely used measure of the environmental impact of buildings. Recent studies have highlighted the importance of both the operational and embodied energy attributable to buildings over their lifetime. The method of assessing lifetime building energy is known as life-cycle energy analysis. With Kyoto target obligations necessitating the quantification of greenhouse gas emissions at the national level, it seems increasingly probable that analyses of this kind will increase in use. If conducted in primary energy terms, such analyses directly reflect greenhouse gas emissions, except for a few processes which involve significant non-energy related emissions such as cement manufacture. A Life-Cycle Assessment would include these issues, as well as other environmental parameters, though probably with a corresponding decrease in system boundary completeness. This paper briefly explains some of the theoretical issues associated with life-cycle energy analysis and then uses an Australian based case s...

The promotion and presentation of the self: celebrity as marker of presentational media

Abstract: This article explores how the celebrity discourse of the self both presages and works as a pedagogical tool for the burgeoning world of presentational media and its users that is now an elemental part of new media culture. What is often understood as social media via social network sites is also a form of presentation of the self and produces this new hybrid among the personal, interpersonal and the mediated – what I am calling ‘presentational media’. Via Facebook, MySpace, Friendster and Twitter individuals engage in an expression of the self that, like the celebrity discourse of the self, is not entirely interpersonal in nature nor is it entirely highly mediated or representational. This middle ground of self-expression – again partially mediated and partially interpersonal (and theoretically drawing from Erving Goffman's work) – has produced an expansion of the intertextual zone that has been the bedrock of the celebrity industry for more than half a century and now is the very centre of the social med...

Large-scale mechanical peeling of boron nitride nanosheets by low-energy ball milling

Abstract: Mechanical cleavage by Scotch tape was the first method to produce graphene and is still widely used in laboratories. However, a critical problem of this method is the extremely low yield. We have tailored ball milling conditions to produce gentle shear forces that produce high quality boron nitride (BN) nanosheets in high yield and efficiency. The in-plane structure of the BN nanosheets has not been damaged as shown by near edge X-ray absorption fine structure measurements. The benzyl benzoate acts as the milling agent to reduce the ball impacts and milling contamination. This method is applicable to any layered materials for producing nanosheets.

Behavioral epidemiology: a systematic framework to classify phases of research on health promotion and disease prevention.

Abstract: Although the term “behavioral epidemiology” has been used in the literature since the late 1970s, it has not been clearly defined. A behavioral epidemiology framework is proposed to specify a systematic sequence of studies on health-related behaviors, leading to evidence-based interventions directed at populations. The phases are: 1—establish links between behaviors and health; 2—develop measures of the behavior; 3—identify influences on the behavior; 4—evaluate interventions to change the behavior; 5—translate research into practice. Mature research areas are expected to have more studies in the latter phases. Recent volumes of four journals (Annals of Behavioral Medicine, Health Psychology, Journal of Nutrition Education, Tobacco Control) were audited, and empirical studies were classified into these phases. Phase 3 studies were common (identifying influences on behaviors; 27% to 50%), and Phase 2 studies were least common (measurement; 0% to 15%).Annals of Behavioral Medicine andHealth Psychology were low on Phase 4 (intervention studies; 9% and 11%, respectively). TheJournal of Nutrition Education was the only journal reviewed that had a substantial number (20%) of Phase 5 studies (translating research into practice). The behavioral epidemiology framework can be used to evaluate the status of research on health behaviors and to guide research policies.

Amp-activated protein kinase regulates glut4 transcription by phosphorylating histone deacetylase 5

Abstract: OBJECTIVE— Insulin resistance associated with obesity and diabetes is ameliorated by specific overexpression of GLUT4 in skeletal muscle. The molecular mechanisms regulating skeletal muscle GLUT4 expression remain to be elucidated. The purpose of this study was to examine these mechanisms. RESEARCH DESIGN AND METHODS AND RESULTS— Here, we report that AMP-activated protein kinase (AMPK) regulates GLUT4 transcription through the histone deacetylase (HDAC)5 transcriptional repressor. Overexpression of HDAC5 represses GLUT4 reporter gene expression, and HDAC inhibition in human primary myotubes increases endogenous GLUT4 gene expression. In vitro kinase assays, site-directed mutagenesis, and site-specific phospho-antibodies establish AMPK as an HDAC5 kinase that targets S259 and S498. Constitutively active but not dominant-negative AMPK and 5-aminoimidazole-4-carboxamide-1-β-d-ribonucleoside (AICAR) treatment in human primary myotubes results in HDAC5 phosphorylation at S259 and S498, association with 14-3-3 isoforms, and H3 acetylation. This reduces HDAC5 association with the GLUT4 promoter, as assessed through chromatin immunoprecipitation assays and HDAC5 nuclear export, concomitant with increases in GLUT4 gene expression. Gene reporter assays also confirm that the HDAC5 S259 and S498 sites are required for AICAR induction of GLUT4 transcription. CONCLUSIONS— These data reveal a signal transduction pathway linking cellular energy charge to gene transcription directed at restoring cellular and whole-body energy balance and provide new therapeutic targets for the treatment and management of insulin resistance and type 2 diabetes.