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Institution

Deakin University

EducationBurwood, Victoria, Australia
About: Deakin University is a education organization based out in Burwood, Victoria, Australia. It is known for research contribution in the topics: Population & Context (language use). The organization has 12118 authors who have published 46470 publications receiving 1188841 citations. The organization is also known as: Deakin.


Papers
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Journal ArticleDOI
TL;DR: DNA aptamers reported here against cancer biomarker EpCAM will facilitate the development of novel targeted cancer therapy, cancer cell imaging, and circulating tumor cell detection.
Abstract: Epithelial cell adhesion molecule (EpCAM) is overexpressed in most solid cancers and is an ideal antigen for clinical applications in cancer diagnosis, prognosis, imaging, and therapy. Currently, most of the EpCAM-based diagnostic, prognostic, and therapeutic strategies rely on the anti-EpCAM antibody. However, the use of EpCAM antibody is restricted due to its large size and instability. In this study, we have successfully identified DNA aptamers that selectively bind human recombinant EpCAM protein. The aptamers can specifically recognize a number of live human cancer cells derived from breast, colorectal, and gastric cancers that express EpCAM but not bind to EpCAM-negative cells. Among the aptamer sequences identified, a hairpin-structured sequence SYL3 was optimized in length, resulting in aptamer sequence SYL3C. The Kd values of the SYL3C aptamer against breast cancer cell line MDA-MB-231 and gastric cancer cell line Kato III were found to be 38 ± 9 and 67 ± 8 nM, respectively, which are better than...

373 citations

Journal ArticleDOI
TL;DR: The efficacy pattern of NAC interestingly shows little respect for the current diagnostic systems, and its benign tolerability profile, its action on multiple operative pathways, and the emergence of positive trial data make it one of the most promising drug candidates in neuropsychiatric disorders.

372 citations

Journal ArticleDOI
TL;DR: Analytical proof that classic mutual information cannot be considered a measure for image fusion performance is provided.
Abstract: The unsuitability of using classic mutual information measure as a performance measure for image fusion is discussed Analytical proof that classic mutual information cannot be considered a measure for image fusion performance is provided

372 citations

Journal ArticleDOI
TL;DR: It is suggested that the prevalence of premature ejaculation is considerably lower than previously thought and that ongoing research will lead to a more complete understanding of the pathophysiology as well as new efficacious and safe treatments for this sexual dysfunction.

370 citations


Authors

Showing all 12448 results

NameH-indexPapersCitations
Patrick D. McGorry137109772092
Mary Story13552264623
Dacheng Tao133136268263
Paul Harrison133140080539
Paul Zimmet128740140376
Neville Owen12770074166
Louisa Degenhardt126798139683
David Scott124156182554
Anthony F. Jorm12479867120
Tao Zhang123277283866
John C. Wingfield12250952291
John J. McGrath120791124804
Eduard Vieta119124857755
Michael Berk116128457743
Ashley I. Bush11656057009
Network Information
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023162
2022677
20215,124
20204,513
20193,981
20183,543