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Institution

Deen Dayal Upadhyay Gorakhpur University

EducationGorakhpur, Uttar Pradesh, India
About: Deen Dayal Upadhyay Gorakhpur University is a education organization based out in Gorakhpur, Uttar Pradesh, India. It is known for research contribution in the topics: Thermal decomposition & Lymnaea acuminata. The organization has 1032 authors who have published 1591 publications receiving 21734 citations. The organization is also known as: Gorakhpur University.


Papers
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Journal Article
TL;DR: It is proposed that the fifth fraction of E. royleana latex can be used as a molluscicide for controlling the harmful snail population from aquatic ecosystem without any harm due to their reversible toxic action.
Abstract: Laboratory evaluation was made to assess the molluscicidal activity of different fractions of Euphorbia royleana (Family- Euphorbiaceae) latex obtained through sephadex gel column against freshwater snail Lymnaea (Radix) acuminata Lamarack. This snail is the vector of liver fluke, Fasciola hepatica Linnaeus and Fasciola gigantica Cobbold, which causes endemic fascioliasis in cattle and livestock. The toxic effect of the different fractions was time dependent and fifth fraction obtained through benzene: ethyl acetate (5:5) had maximum molluscicidal activity against Lymnaea acuminata. There was a significant negative correlation between LC values and exposure periods thus increase in exposure time, the LC 5 0 value of V fraction of Euphorbia royleana latex was decreased from 14.28 mg/l (24 hr) to 9.28 mg/l (96 hr) against Lymnaea acuminata. After exposure to sub-lethal concentrations of this fraction there were significant time and dose dependent alterations observed in pyruvate, lactate levels, ALAT, AAT, AChE and cytochrome oxidase enzyme activities in different body tissues of Lymnaea acuminata. It is proposed that the fifth fraction of E. royleana latex can be used as a molluscicide for controlling the harmful snail population from aquatic ecosystem without any harm due to their reversible toxic action.

12 citations

Journal ArticleDOI
TL;DR: The molecular dynamics simulation of the best-docked poses for 50 ns demonstrates that molecules 7 and 10 exhibit better tendencies of binding with the microtubule and average RMSD analysis and dynamical pathway observations indicate that these molecules transit quickly to a dynamically stable configuration and seem to achieve a comfort zone by remaining stable throughout the dynamics.
Abstract: The screening of a variety of botanical species and marine organisms provided satisfactory novel tubulin binding agents (TBAs). The current study aims to quantify the binding capabilities of several TBAs including vinca alkaloids, colchicine and other taxol-domain binding agents with microtubule. The stability of the bound complexes and detailed interactions within the active site are the endeavor of the study. Different natural extracts reported as TBAs, have been screened against the refined structure of αβ-tubulin hetero-dimers using ligand docking. The molecular dynamics simulation of the best-docked poses for 50 ns demonstrates that molecules 7 (discodermolide) and 10 (laulimalide) exhibit better tendencies of binding with the microtubule. Average RMSD analysis and dynamical pathway observations indicate that these molecules transit quickly to a dynamically stable configuration and seem to achieve a comfort zone by remaining stable throughout the dynamics. The results obtained, may form the foundation for the future synthesis and evaluation of new compounds with potential tubulin binding properties.

12 citations

Journal ArticleDOI
TL;DR: In this paper, cobalt(II)5- (2′-hydroxyphenyl)-3-(4-substituted-phenyl) pyrazolinates of the type (C15H12N2OX)2Co have been synthesized by reaction of anhydrous cobalt (II)chloride with the sodium salt of the pyrazolineines in 1 : 2 molar ratio.
Abstract: 5(2′-Hydroxyphenyl)-3-(4-substituted-phenyl)pyrazolinates of cobalt(II) of the type (C15H12N2OX)2Co [here substituted group X is–H,–Cl,–CH3 or–OCH3] have been synthesized by reaction of anhydrous cobalt(II)chloride with the sodium salt of the pyrazolines in 1 : 2 molar ratio. Their addition complexes with N and P donor ligands [2, 2′-bipyridine, 1, 10-phenanthroline and triphenylphosphine] were prepared in 1 : 1 molar ratio. The newly synthesized complexes were characterized by elemental analyses, molecular weight measurement, magnetic susceptibility, IR, electronic, 31P NMR and FAB mass spectra. All complexes are amorphous as determined by XRD. Tetrahedral geometry around cobalt(II) has been suggested, confirming the presence of two pyrazoline bidentate ligands, cobalt(II)5- (2′-hydroxyphenyl)-3-(4-substituted-phenyl)pyrazolinates. Upon ligand addition, pyrazoline changes to monodentate. The bidentate and monodentate behavior of pyrazoline ligands was confirmed by IR spectral data. The metal complexes an...

12 citations

Journal Article
TL;DR: The effect of dried clove powder of Allium sativum, dried latex powder of Ferula asafoetida and dried flower bud powder of Syzygium aromaticum in in vitro treatment against liver fluke Fasciola gigantica and ethanol extract was more toxic than other organic extract.
Abstract: The effect of dried clove powder of Allium sativum, dried latex powder of Ferula asafoetida and dried flower bud powder of Syzygium aromaticum in in vitro treatment against liver fluke Fasciola gigantica were studied. The anthelmintic activities of all the three plants were time and concentration dependent. A. sativum bulb powder 8h LC50 against F. gigantica was 5.48 mg/ml. Among different organic extracts, ethanol extract was more toxic than other organic extract. The ethanol extract of S. aromaticum (2h LC50 2.95 mg/ml) was more toxic against F. gigantica than A. sativum (2h LC50 3.48 mg/ml) and F. asafoetida (2h LC50 3.94 mg/ml). The 8h LC50 of column purified fraction of dried flower bud powder of S. aromaticum was 1.02 mg/ml whereas dried clove powder of A. sativum and latex powder of F. asafoetida were 1.87 and 2.75 mg/ml, respectively. The product of A. sativum, F. asafoetida and S. aromaticum may be used as anthelmintic.

12 citations

Journal ArticleDOI
TL;DR: In this paper, a PANI-Ferrite nanocomposites were fabricated with the combination of polyaniline and zinc-cobalt ferrites (Co1-xZnxFe2O4, 0.1 ≤ x ≤ 0.4).
Abstract: Ultrahigh efficient and effective electromagnetic-interference (EMI) shielding composites have been fabricated with the combination of Polyaniline and zinc-cobalt ferrites (Co1-xZnxFe2O4, 0.1 ≤ x ≤ 0.4). Ferrite nanoparticles synthesized via the sol-gel method were functionalized to polyaniline via in situ polymerization. Average crystallite sizes of the nanoparticles were estimated using Debye–Scherrer and Rietveld method and found to be in between 20-30 nm. FTIR spectra revealed the formation of interactions between the PANI molecules and the ferrite nanoparticles. Substitution of the nonmagnetic Zn ions considerably changes the magnetic properties of cobalt ferrites as observed from the M-H loops recorded by VSM at room temperature. The EMI-shielding performance of the fabricated composites was examined at various thicknesses with the polymer filler ratio of 1:1 in X-band frequency region using a vector network analyser. The EMI shielding performance of composites was found to be increasing with the thickness of composites where a thickness of 3.0 mm achieved an SE of ∼ 100 dB for the Co0.7Zn0.3Fe2O4-PANI composite. Composite absorbers were deposited on cotton fabrics for protective clothing by in situ incorporation during the synthesis of composites which displayed relatively high EMI shielding effectiveness (SE) (40-45 dB) at a thickness of only 0.30 mm for the fabrics. The PANI-Ferrite nanocomposites can be established as promising high capacity electromagnetic shielding materials because of the dipole polarization and the magnetic losses with low cost, lightweight, high durability and good flexibility.

12 citations


Authors

Showing all 1045 results

NameH-indexPapersCitations
Rudra Deo Tripathi571389640
Nawal Kishore Dubey5022910796
Harikesh Bahadur Singh463077372
Souvik Maiti432375759
Ajay Singh392568464
Alok C. Gupta391314052
Suman K Mishra382404989
Gurdip Singh361575173
Ram C. Mehrotra355066259
Nidhi Gupta352664786
Ajay K. Mishra342195050
Seema Mishra33794312
Narsingh Bahadur Singh331944062
Manish Naja321103383
Maya Shankar Singh312454261
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
20239
202216
2021118
202094
201965
201869