Deen Dayal Upadhyay Gorakhpur University

About: Deen Dayal Upadhyay Gorakhpur University is a education organization based out in Gorakhpur, Uttar Pradesh, India. It is known for research contribution in the topics: Thermal decomposition & Lymnaea acuminata. The organization has 1032 authors who have published 1591 publications receiving 21734 citations. The organization is also known as: Gorakhpur University.

Conformational flexibility, binding energy, role of salt bridge and alanine-mutagenesis for c-Abl kinase complex

Abstract: Abl kinase plays a decisive role in the mechanism of the most fatal human pathogen chronic mylogenous leukemia (CML). Here, we have carried out a comprehensive study about the conformational flexibility, role of salt bridge and the protein- ligand interaction for this kinase with its well-known inhibitor, Imatinib. We have performed molecular dynamics simulations for conformational behavior, investigated the salt bridges and calculated the binding free energy of Imatinib with MM-PB/SA method for Abl kinase complex. We also explored the role of salt-bridge in the kinase complex and its effect on binding activity of inhibitors. Furthermore, to investigate the importance of those residues which form salt bridges, we mutated them by Alanine with the help of Alanine scanning program. We noticed significant variations in total free energy of Imatinib in all possible mutations. The binding free energy of ligand for kinase receptor was analyzed by molecular mechanics Poission Boltzmann surface area (MM-PB/SA) method. These results suggest that conserved glutamic acid and lysine are necessary for stability of complex.

Business process reengineering: a recent review

Abstract: Business process reengineering (BPR) is a tool to help organizations to improve Quality, customer services, cut operational costs and become leaders in their domain. BPR could act as an important strategic tool for sustained competitive advantage for foreign or Indian manufacturing companies (public and private) in the present context. This paper was conducted with the aim to collect and review the work done so far in the field of BPR and quality management. Focus of this study was on providing a comprehensive overview of overall development of BPR concept, theories, approaches, challenges and outcomes. Conclusion drawn was based on the previous research studies and it was concluded that application of BPR in Indian manufacturing sector is not difficult, despite the fact that the situations are different and the reasons for adaptation vary in this sector. There is still a need for exclusive and universally acceptable model for BPR as well as a commonly applicable methodology.

Enzymatic characteristics of ligninperoxidases from Penicillium citrinum, Fusarium oxysporum and Aspergillus terreus using n-propanol as substrate.

Abstract: The activities of ligninperoxidases from Penicillium citrinum MTCC 3565, Fusarium oxysporum MTCC 3379 and Aspergillus terreus MTCC 3374 have been assayed and the enzymatic characteristics like K m , pH and temperature optima using n-propanol as the substrate have been reported. The results suggest that n-propanol can substitute veratryl alcohol as substrate for assaying ligninperoxidase activities from different fungal strains, without affecting the enzymatic characteristics. The above strains were selected, as they were known to secrete ligninperoxidase in the liquid culture medium.