Deen Dayal Upadhyay Gorakhpur University

About: Deen Dayal Upadhyay Gorakhpur University is a education organization based out in Gorakhpur, Uttar Pradesh, India. It is known for research contribution in the topics: Thermal decomposition & Lymnaea acuminata. The organization has 1032 authors who have published 1591 publications receiving 21734 citations. The organization is also known as: Gorakhpur University.

Antifungal properties of leaf extract of Ranunculus sceleratus L.

Abstract: Studies on various antifungal properties of the leaf extract ofRanunculus sceleratus L. showed that it was thermostable up to 100°C, retained activity on autoclaving, and remained active up to 15 days at room temperature. It possessed quick fungicidal action, tolerance against heavy fungal inoculum, activity on broad pH range, broad fungicidal spectrum, non-phytotoxicity and non-systemic activity. The extract was lethal at 1∶40 dilution and its volatile vapours were also fungitoxic.

Rapid optical variability in radio-quiet QSOs

Abstract: ABSTRA C T We report results of the observations at the Vainu Bappu Observatory and the Uttar Pradesh State Observatory of eight radio-quiet quasi-stellar objects (RQQSOs) during 1996‐99. This is a part of our ongoing programme to search for intranight optical variability in RQQSOs. Additional evidence for very rapid variability in three of the five optically bright and very luminous RQQSOs we had observed earlier, 10492006, 14441408 and 16301377, was found. Of the three newly observed RQQSOs, the data for 00431039 are too noisy to allow conclusions about variability to be drawn, but 07481294 and 08241098 show strong hints of microvariability. We also present a summary of the results from our entire programme to date, which includes observations of 16 radio-quiet QSOs and one radio-weak QSO, and compare the general properties of rapid variability in radio-quiet versus radio-loud AGN as determined from our work and that of several other groups. Observations of this kind are likely to play a key role in understanding the relative contributions of accretion discs and relativistic plasma jets to rapid optical fluctuations of AGN.

Pyrazolo[3,4-d]pyrimidines as inhibitor of anti-coagulation and inflammation activities of phospholipase A 2 : insight from molecular docking studies

Abstract: Phospholipase A2 (PLA2), isolated from Daboia russelli pulchella (Russell’s viper), is enzymatically active as well as induces several pharmacological disorders including neurotoxicity, myotoxicity, cardiotoxicity, anti-coagulant, hemolytic, and platelet effects. Indomethacin reduces the effects of anti-coagulant and pro-inflammatory actions of PLA2. Pyrazolo[3,4-d]pyrimidines constitute a class of naturally occurring fused uracils that posses diverse biological activities. The in-silico docking studies of nine pyrazolo[3,4-d]pyrimidine molecules have been carried out with the X-ray crystal structure of Russell’s viper PLA2 (PDB ID: 3H1X) to predict the binding affinity, molecular recognition, and to explicate the binding modes, using AUTODOCK and GLIDE (Standard precision and Extra precision) modules, respectively. Docking results through each method make obvious that pyrazolo[3,4-d]pyrimidine molecules with trimethylene linker can bind with both anti-coagulation and enzymatic regions of PLA2.

Recent Advances in Protein−Ligand Interactions: Molecular Dynamics Simulations and Binding Free Energy

Abstract: Computational techniques are one of the most emerging topics in structural and molecular biology. Molecular dynamics (MD) simulations are used not only to explore the conformational aspects of biological systems but also to have significant scope in protein-ligand interactions. Then the binding free energy calculations are readily applied to the simulated systems in order to predict the binding affinities. The thermodynamic properties are directly related to protein-ligand interactions which are dependent upon a few specific parameters. In the present review, we highlight some facts related to protein-ligand complexes, by starting with a survey of MD simulations and binding free energy calculations and ending with some successful implementations of these computational techniques.