Institution
Deen Dayal Upadhyay Gorakhpur University
Education•Gorakhpur, Uttar Pradesh, India•
About: Deen Dayal Upadhyay Gorakhpur University is a education organization based out in Gorakhpur, Uttar Pradesh, India. It is known for research contribution in the topics: Thermal decomposition & Lymnaea acuminata. The organization has 1032 authors who have published 1591 publications receiving 21734 citations. The organization is also known as: Gorakhpur University.
Papers published on a yearly basis
Papers
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TL;DR: A conserved Pec_Lyase_C domain uniformly observed in all pectate lyases irrespective of variable sources suggesting its possible role in structural and enzymatic functions.
Abstract: A total of 121 protein sequences of pectate lyases were subjected to homology search, multiple sequence alignment, phylogenetic tree construction, and motif analysis. The phylogenetic tree constructed revealed different clusters based on different source organisms representing bacterial, fungal, plant, and nematode pectate lyases. The multiple accessions of bacterial, fungal, nematode, and plant pectate lyase protein sequences were placed closely revealing a sequence level similarity. The multiple sequence alignment of these pectate lyase protein sequences from different source organisms showed conserved regions at different stretches with maximum homology from amino acid residues 439–467, 715–816, and 829–910 which could be used for designing degenerate primers or probes specific for pectate lyases. The motif analysis revealed a conserved Pec_Lyase_C domain uniformly observed in all pectate lyases irrespective of variable sources suggesting its possible role in structural and enzymatic functions.
26 citations
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TL;DR: In this paper, the authors applied computational screening and evaluation of FDA-approved drugs for highly selective modulation of Sirt2 activity via a unique inhibitory mechanism as reported earlier for SirReal2 inhibitor.
Abstract: Sirtuin 2 (Sirt2) nicotinamide adenine dinucleotide-dependent deacetylase enzyme has been reported to alter diverse biological functions in the cells and onset of diseases, including cancer, aging, and neurodegenerative diseases, which implicate the regulation of Sirt2 function as a potential drug target. Available Sirt2 inhibitors or modulators exhibit insufficient specificity and potency, and even partially contradictory Sirt2 effects were described for the available inhibitors. Herein, we applied computational screening and evaluation of FDA-approved drugs for highly selective modulation of Sirt2 activity via a unique inhibitory mechanism as reported earlier for SirReal2 inhibitor. Application of stringent molecular docking results in the identification of 48 FDA-approved drugs as selective putative inhibitors of Sirt2, but only top 10 drugs with docking scores > − 11 kcal/mol were considered in reference to SirReal2 inhibitor for computational analysis. The molecular dynamics simulations and post-simulation analysis of Sirt2-drug complexes revealed substantial stability for Fluphenazine and Nintedanib with Sirt2. Additionally, developed 3D-QSAR-models also support the inhibitory potential of drugs, which exclusively revealed highest activities for Nintedanib (pIC50 ≥ 5.90 µM). Conclusively, screened FDA-approved drugs were advocated as promising agents for Sirt2 inhibition and required in vitro investigation for Sirt2 targeted drug development.
26 citations
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TL;DR: In this paper, a dilatometric technique was used to measure excess molar volumes for binary mixtures of heptan-1-ol (n-C7H15OH) + pentane (n -C5H12), hexane (N-C6H14), heptane (H16), octane (C8H18), and 2,2,4-trimethylpentane (2,2-4-TMP) at T = 293.
Abstract: Excess molar volumes, have been measured using a dilatometric technique for binary mixtures of heptan-1-ol (n-C7H15OH) + pentane (n-C5H12), + hexane (n-C6H14), + heptane (n-C7H16), + octane (n-C8H18), and + 2,2,4-trimethylpentane (2,2,4-TMP) at T = 293.15 K. has been found to be negative throughout the entire range of composition for (x)n-C7H15OH + (1 − x)n-C5H12, + (1 − x)n-C6H14, and + (1 − x)2,2,4-TMP. has been found to be positive at lower mole fractions of n-C7H15OH and negative at higher mole fractions of n-C7H15OH for (x)n-C7H15OH + (1 − x)n-C7H16 and (x)n-C7H15OH + (1 − x)n-C8H18 with an inversion of sign from positive to negative values of occurring at x ∼ 0.18 and x ∼ 0.43, respectively, for these mixtures. has been fitted in a smoothing equation.
26 citations
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TL;DR: Extracts of Capparis decidua stems and flowers showed insecticidal and oviposition inhibitory activities against Bruchus chinensis and one novel compound labeled as CDF1 has been isolated and identified as 6-(1-hydroxy-non-3-enyl)tetrahydropyran-2-one.
Abstract: Extracts of Capparis decidua stems and flowers showed insecticidal and oviposition inhibitory activities against Bruchus chinensis. The LC50 values of these extracts were found to increase with the increase in the polarity of the extract at different exposure periods. For instance, after 96 h, the LC50 values were found to be 3.619, 7.319, and 10.151 μg for CD1, CD2, and CD3, respectively. Extract CD7 was effective only at higher doses. The toxicity was found to be dose- and time-dependent. The females laid lesser number of eggs, when exposed to sublethal doses of different extracts and pure compounds, as compared to control. The maximum oviposition deterrence index was found for extract CD1 followed in decreasing order by CD2, CD3, and CD7. From extract CD1, two compounds were isolated and characterized as triacontanol (C1) and 2-carboxy-1,1-dimethylpyrrolidine (C2). When the females were exposed to sublethal doses of these compounds, they laid lesser number of eggs as compared to the control. C2 was fou...
26 citations
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TL;DR: In this article, the linear velocity of crystallization I for pure components and eutectics was found to depend on Δ according to the equation I = K ( ΔT ) n, where K and n are constants.
26 citations
Authors
Showing all 1045 results
Name | H-index | Papers | Citations |
---|---|---|---|
Rudra Deo Tripathi | 57 | 138 | 9640 |
Nawal Kishore Dubey | 50 | 229 | 10796 |
Harikesh Bahadur Singh | 46 | 307 | 7372 |
Souvik Maiti | 43 | 237 | 5759 |
Ajay Singh | 39 | 256 | 8464 |
Alok C. Gupta | 39 | 131 | 4052 |
Suman K Mishra | 38 | 240 | 4989 |
Gurdip Singh | 36 | 157 | 5173 |
Ram C. Mehrotra | 35 | 506 | 6259 |
Nidhi Gupta | 35 | 266 | 4786 |
Ajay K. Mishra | 34 | 219 | 5050 |
Seema Mishra | 33 | 79 | 4312 |
Narsingh Bahadur Singh | 33 | 194 | 4062 |
Manish Naja | 32 | 110 | 3383 |
Maya Shankar Singh | 31 | 245 | 4261 |