Institution
Deen Dayal Upadhyay Gorakhpur University
Education•Gorakhpur, Uttar Pradesh, India•
About: Deen Dayal Upadhyay Gorakhpur University is a education organization based out in Gorakhpur, Uttar Pradesh, India. It is known for research contribution in the topics: Thermal decomposition & Lymnaea acuminata. The organization has 1032 authors who have published 1591 publications receiving 21734 citations. The organization is also known as: Gorakhpur University.
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TL;DR: In this article, the authors measured the excess molar volumes, relative permittivities, er, and refractive indexes, nD for binary mixtures of 1,1,2,2-tetrachloroethane (CHCl2CHClCl2) with pyridine (C5H5N), anisole (C6H5OCH3), methyl ethyl ketone (CH3COC2H5), and 1,4-dioxane (1, 4-C4H8O2) at 303
Abstract: Excess molar volumes, relative permittivities, er, and refractive indexes, nD, have been measured for binary mixtures of 1,1,2,2-tetrachloroethane (CHCl2CHCl2) with pyridine (C5H5N), anisole (C6H5OCH3), methyl ethyl ketone (CH3COC2H5), and 1,4-dioxane (1,4-C4H8O2) at 303.15 K. has been found to be negative throughout the entire mole fraction range for all these mixtures. The values of the deviations of er and nD from a mole fraction average, which are represented respectively by Δer and ΔnD have been calculated. The results of ΔnD, and Δer for the various mixtures have been fitted by the method of least squares to smoothing equations.
16 citations
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TL;DR: Green tea contained potential compounds with an ability to inhibit the cancer by disrupting the co‐chaperon p23 activity, and structure‐based virtual screening from Traditional Chinese Medicine database supported the fact.
Abstract: Co-chaperon p23 has been well established as molecular chaperon for the heat shock protein 90 (Hsp90) that further leads to immorality in cancer cells by providing defense against Hsp90 inhibitors, and as stimulating agent for generating overexpressed antiapoptotic proteins, that is, Hsp70 and Hsp27. The natural compounds such as catechins from Camellia sinensis (green tea) are also well known for inhibition activity against various cancer. However, molecular interaction profile and potential lead bioactive compounds against co-chaperon p23 from green tea are not yet reported. To this context, we study the various secondary metabolites of green tea against co-chaperon p23 using structure-based virtual screening from Traditional Chinese Medicine (TCM) database. Following 26 compounds were obtained from TCM database and further studied for extra precision molecular docking that showed binding score between -10.221 and -2.276 kcal/mol with co-chaperon p23. However, relative docking score to known inhibitors, that is, ailanthone (-4.54 kcal/mol) and gedunin ( 3.60 kcal/mol) along with ADME profile analysis concluded epicatechin (-7.013 kcal/mol) and cis-theaspirone (-4.495 kcal/mol) as potential lead inhibitors from green tea against co-chaperone p23. Furthermore, molecular dynamics simulation and molecular mechanics generalized born surface area calculations validated that epicatechin and cis-theaspirone have significantly occupied the active region of co-chaperone p23 by hydrogen and hydrophobic interactions with various residues including most substantial amino acids, that is, Thr90, Ala94, and Lys95. Hence, these results supported the fact that green tea contained potential compounds with an ability to inhibit the cancer by disrupting the co-chaperon p23 activity.
16 citations
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TL;DR: In this paper, the impact of lockdown on the dynamics of novel Corona Virus Disease (COVID-19) emerged in Wuhan city of China in December 2019 is studied.
16 citations
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TL;DR: In this article, an octahedral geometry has been established for all the ruthenium(III) complexes except [Ru(L″)Cl2]n, which is pentacoordinate and a trigonal-bipyramidal environment, D3h, has been suggested for the RIT ion.
Abstract: Ruthenium(III) complexes of types [Ru(L)3], [Ru(L′)Cl(H2O)2], [Ru(L″)Cl2]n, [Ru(L‴)Cl(H2O)]n(LH =Schiff bases derived from anthranilic acid and benzaldehyde, acetophenone, vanillin, cinnamaldehyde orm-hydroxyacetophenone; L′H2=Schiff bases derived from anthranilic acid and salicylaldehyde oro-hydroxyacetophenone; L″H=Schiff bases derived fromp-aminobenzoic acid and benzaldehyde, acetophenone, vanillin, cinnamaldehyde orm-hydroxyacetophenone; L‴H2=Schiff bases derived fromp-aminobenzoic acid and salicylaldehyde oro-hydroxyacetophenone) have been synthesized and characterized on the basis of elemental analyses, conductance, magnetic moment and spectral (electronic, i.r. and1H n.m.r.) data. The wavelengths of the principal electronic absorption peaks have been accounted for quantitatively in terms of crystal field theory and various parameters have been evaluated. On the basis of the electronic spectra, an octahedral geometry has been established for all these complexes except [Ru(L″)Cl2]n. The complexes [Ru(L″)Cl2]n are pentacoordinate and a trigonal-bipyramidal environment, D3h, is suggested for the ruthenium(III) ion. The thermal behaviour of these complexes has also been studied by t.g., d.t.g and d.s.c techniques. Heats of reaction for the decomposition steps were calculated from the d.s.c. curves. The antifungal and antiviral activities of the complexes with Schiff bases derived from anthranilic acid were also investigated.
16 citations
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TL;DR: Nickel and copper nitrate complexes with 2,2′-bipyridine (bipy) as a N donor and nitrate and water as oxygen donor ligands of the general formula [M(NO 3 )(C 10 H 8 N 2 )(H 2 O) 3 ](NO3 ), where M = Ni and Cu, have been obtained from the corresponding metal nitrate salts.
16 citations
Authors
Showing all 1045 results
Name | H-index | Papers | Citations |
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Rudra Deo Tripathi | 57 | 138 | 9640 |
Nawal Kishore Dubey | 50 | 229 | 10796 |
Harikesh Bahadur Singh | 46 | 307 | 7372 |
Souvik Maiti | 43 | 237 | 5759 |
Ajay Singh | 39 | 256 | 8464 |
Alok C. Gupta | 39 | 131 | 4052 |
Suman K Mishra | 38 | 240 | 4989 |
Gurdip Singh | 36 | 157 | 5173 |
Ram C. Mehrotra | 35 | 506 | 6259 |
Nidhi Gupta | 35 | 266 | 4786 |
Ajay K. Mishra | 34 | 219 | 5050 |
Seema Mishra | 33 | 79 | 4312 |
Narsingh Bahadur Singh | 33 | 194 | 4062 |
Manish Naja | 32 | 110 | 3383 |
Maya Shankar Singh | 31 | 245 | 4261 |