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Showing papers by "Delft University of Technology published in 2010"


Journal ArticleDOI
TL;DR: The Lgr5 stem cell marker and culture method described here will be invaluable tools for accelerating research into gastric epithelial renewal, inflammation/infection, and cancer.

1,342 citations


Journal ArticleDOI
TL;DR: In this article, a specific group of alkali-resistant spore-forming bacteria related to the genus Bacillus was selected for this purpose, and the bacterial spores directly added to the cement mixture remained viable for a period up to 4 months.

1,070 citations


Journal ArticleDOI
TL;DR: In this paper, it was shown that the magnetic insulator LaY(2)Fe(5)O(12) can convert a heat flow into a spin voltage, which can then be converted into an electric voltage as a result of the inverse spin Hall effect.
Abstract: Thermoelectric generation is an essential function in future energy-saving technologies. However, it has so far been an exclusive feature of electric conductors, a situation which limits its application; conduction electrons are often problematic in the thermal design of devices. Here we report electric voltage generation from heat flowing in an insulator. We reveal that, despite the absence of conduction electrons, the magnetic insulator LaY(2)Fe(5)O(12) can convert a heat flow into a spin voltage. Attached Pt films can then transform this spin voltage into an electric voltage as a result of the inverse spin Hall effect. The experimental results require us to introduce a thermally activated interface spin exchange between LaY(2)Fe(5)O(12) and Pt. Our findings extend the range of potential materials for thermoelectric applications and provide a crucial piece of information for understanding the physics of the spin Seebeck effect.

1,011 citations


Journal ArticleDOI
TL;DR: High-resolution maps of genome-nuclear lamina interactions during subsequent differentiation of mouse embryonic stem cells via lineage-committed neural precursor cells into terminally differentiated astrocytes suggest that lamina-genome interactions are widely involved in the control of gene expression programs during lineage commitment and terminal differentiation.

933 citations


Book
01 Feb 2010
TL;DR: The SWAN wave model as discussed by the authors is a wave model based on linear wave theory (SWAN) for oceanic and coastal waters, and it has been shown to be effective in detecting ocean waves.
Abstract: 1. Introduction 2. Observation techniques 3. Description of ocean waves 4. Statistics 5. Linear wave theory (oceanic waters) 6. Waves in oceanic waters 7. Linear wave theory (coastal waters) 8. Waves in coastal waters 9. The SWAN wave model Appendices References Index.

874 citations


Journal ArticleDOI
TL;DR: This article conducted a survey of the current literature in order to identify the determinants for commuting by bicycle and found many determinants, not all of which are addressed by conventional mode choice studies and models.

862 citations


Journal ArticleDOI
Th. de Graauw1, Th. de Graauw2, Frank Helmich2, Thomas G. Phillips3  +176 moreInstitutions (20)
TL;DR: The Heterodyne Instrument for the Far-Infrared (HIFI) was launched onboard ESA's Herschel Space Observatory in May 2009 as mentioned in this paper, which is a set of 7 heterodyne receivers that are electronically tuneable, covering 480-1250 GHz with SIS mixers and the 1410-1910 GHz range with hot electron bolometer mixers.
Abstract: Aims. This paper describes the Heterodyne Instrument for the Far-Infrared (HIFI) that was launched onboard ESA's Herschel Space Observatory in May 2009. Methods. The instrument is a set of 7 heterodyne receivers that are electronically tuneable, covering 480-1250 GHz with SIS mixers and the 1410-1910 GHz range with hot electron bolometer (HEB) mixers. The local oscillator (LO) subsystem comprises a Ka-band synthesizer followed by 14 chains of frequency multipliers and 2 chains for each frequency band. A pair of auto-correlators and a pair of acousto-optical spectrometers process the two IF signals from the dual-polarization, single-pixel front-ends to provide instantaneous frequency coverage of 2 × 4 GHz, with a set of resolutions (125 kHz to 1 MHz) that are better than 0.1 km s-1. Results. After a successful qualification and a pre-launch TB/TV test program, the flight instrument is now in-orbit and completed successfully the commissioning and performance verification phase. The in-orbit performance of the receivers matches the pre-launch sensitivities. We also report on the in-orbit performance of the receivers and some first results of HIFI's operations.

828 citations


Proceedings ArticleDOI
14 Mar 2010
TL;DR: An objective intelligibility measure is presented, which shows high correlation (rho=0.95) with the intelligibility of both noisy, and TF-weighted noisy speech, and shows significantly better performance than three other, more sophisticated, objective measures.
Abstract: Existing objective speech-intelligibility measures are suitable for several types of degradation, however, it turns out that they are less appropriate for methods where noisy speech is processed by a time-frequency (TF) weighting, e.g., noise reduction and speech separation. In this paper, we present an objective intelligibility measure, which shows high correlation (rho=0.95) with the intelligibility of both noisy, and TF-weighted noisy speech. The proposed method shows significantly better performance than three other, more sophisticated, objective measures. Furthermore, it is based on an intermediate intelligibility measure for short-time (approximately 400 ms) TF-regions, and uses a simple DFT-based TF-decomposition. In addition, a free Matlab implementation is provided.

791 citations


Journal ArticleDOI
TL;DR: In this article, the authors present six dimensions: Variety, learning capacity, room for autonomous change, leadership, availability of resources and fair governance to assess if institutions stimulate the adaptive capacity of society to respond to climate change from local through to national level.

708 citations


Journal ArticleDOI
01 Oct 2010-Science
TL;DR: This work strongly suppressed the coupling of a single spin in diamond with the surrounding spin bath by using double-axis dynamical decoupling and preserved the coherence was preserved for arbitrary quantum states, as verified by quantum process tomography.
Abstract: Controlling the interaction of a single quantum system with its environment is a fundamental challenge in quantum science and technology. We strongly suppressed the coupling of a single spin in diamond with the surrounding spin bath by using double-axis dynamical decoupling. The coherence was preserved for arbitrary quantum states, as verified by quantum process tomography. The resulting coherence time enhancement followed a general scaling with the number of decoupling pulses. No limit was observed for the decoupling action up to 136 pulses, for which the coherence time was enhanced more than 25 times compared to that obtained with spin echo. These results uncover a new regime for experimental quantum science and allow us to overcome a major hurdle for implementing quantum information protocols.

657 citations


Journal ArticleDOI
TL;DR: The dispersive energy-level shift of an LC resonator magnetically coupled to a superconducting qubit is measured, which clearly shows that the system operates in the ultrastrong coupling regime.
Abstract: We measure the dispersive energy-level shift of an LC resonator magnetically coupled to a superconducting qubit, which clearly shows that our system operates in the ultrastrong coupling regime. The large mutual kinetic inductance provides a coupling energy of ?0.82??GHz, requiring the addition of counter-rotating-wave terms in the description of the Jaynes-Cummings model. We find a 50 MHz Bloch-Siegert shift when the qubit is in its symmetry point, fully consistent with our analytical model.

Journal ArticleDOI
TL;DR: Mixture adsorption, as studied by breakthrough experiments, demonstrates that gate-opening effects can be effectively used to separate molecules of very similar size.
Abstract: Ethane is selectively adsorbed over ethylene in their mixtures on the zeolite imidazolate framework ZIF-7. In packed columns, this results in the direct production of pure ethylene. This gas-phase separation is attributed to a gate-opening effect in which specific threshold pressures control the uptake and release of individual molecules. These threshold pressures differ for the different molecules, leaving a window of selective uptake operation. This phenomenon makes ZIF-7 a perfect candidate for the separation of olefins from paraffins, since in contrast to most microporous materials, the paraffin is selectively adsorbed. Mixture adsorption, as studied by breakthrough experiments, demonstrates that gate-opening effects can be effectively used to separate molecules of very similar size.

Journal ArticleDOI
TL;DR: In this article, the authors make use of new definitions of moisture recycling to study the complete process of continental moisture feedback and identify regions that rely heavily on recycled moisture as well as those that are supplying the moisture.
Abstract: There has been a long debate on the extent to which precipitation relies on terrestrial evaporation (moisture recycling). In the past, most research focused on moisture recycling within a certain region only. This study makes use of new definitions of moisture recycling to study the complete process of continental moisture feedback. Global maps are presented identifying regions that rely heavily on recycled moisture as well as those that are supplying the moisture. An accounting procedure based on ERA‐Interim reanalysis data is used to calculate moisture recycling ratios. It is computed that, on average, 40% of the terrestrial precipitation originates from land evaporation and that 57% of all terrestrial evaporation returns as precipitation over land. Moisture evaporating from the Eurasian continent is responsible for 80% of China’s water resources. In South America, the Rio de la Plata basin depends on evaporation from the Amazon forest for 70% of its water resources. The main source of rainfall in the Congo basin is moisture evaporated over East Africa, particularly the Great Lakes region. The Congo basin in its turn is a major source of moisture for rainfall in the Sahel. Furthermore, it is demonstrated that due to the local orography, local moisture recycling is a key process near the Andes and the Tibetan Plateau. Overall, this paper demonstrates the important role of global wind patterns, topography and land cover in continental moisture recycling patterns and the distribution of global water resources.

Journal ArticleDOI
TL;DR: It is shown how spin Hall effects can be quantified by integrating Ni{80}Fe{20}|normal metal (N) bilayers into a coplanar waveguide and developed a theory that accounts for both.
Abstract: Spin Hall effects intermix spin and charge currents even in nonmagnetic materials and, therefore, ultimately may allow the use of spin transport without the need for ferromagnets. We show how spin Hall effects can be quantified by integrating Ni80Fe20|normal metal (N) bilayers into a coplanar waveguide. A dc spin current in N can be generated by spin pumping in a controllable way by ferromagnetic resonance. The transverse dc voltage detected along the Ni80Fe20|N has contributions from both the anisotropic magnetoresistance and the spin Hall effect, which can be distinguished by their symmetries. We developed a theory that accounts for both. In this way, we determine the spin Hall angle quantitatively for Pt, Au, and Mo. This approach can readily be adapted to any conducting material with even very small spin Hall angles.

Journal ArticleDOI
23 Dec 2010-Nature
TL;DR: In this paper, a spin-orbit quantum bit (qubit) is implemented in an indium arsenide nanowire, where the spinorbit interaction is so strong that spin and motion can no longer be separated.
Abstract: Motion of electrons can influence their spins through a fundamental effect called spin–orbit interaction This interaction provides a way to control spins electrically and thus lies at the foundation of spintronics Even at the level of single electrons, the spin–orbit interaction has proven promising for coherent spin rotations Here we implement a spin–orbit quantum bit (qubit) in an indium arsenide nanowire, where the spin–orbit interaction is so strong that spin and motion can no longer be separated In this regime, we realize fast qubit rotations and universal single-qubit control using only electric fields; the qubits are hosted in single-electron quantum dots that are individually addressable We enhance coherence by dynamically decoupling the qubits from the environment Nanowires offer various advantages for quantum computing: they can serve as one-dimensional templates for scalable qubit registers, and it is possible to vary the material even during wire growth Such flexibility can be used to design wires with suppressed decoherence and to push semiconductor qubit fidelities towards error correction levels Furthermore, electrical dots can be integrated with optical dots in p–n junction nanowires The coherence times achieved here are sufficient for the conversion of an electronic qubit into a photon, which can serve as a flying qubit for long-distance quantum communication

Journal ArticleDOI
TL;DR: For a long-term initiative to address the regional implications of environmental change, hydrologists must become both synthesists and analysts, understanding the functioning of individual system components, while operating firmly within a well-designed hypothesis testing framework.
Abstract: Human activities exert global-scale impacts on our environment with significant implications for freshwater-driven services and hazards for humans and nature. Our approach to the science of hydrology needs to significantly change so that we can understand and predict these implications. Such an adjustment is a necessary prerequisite for the development of sustainable water resource management strategies and to achieve long-term water security for people and the environment. Hydrology requires a paradigm shift in which predictions of system behavior that are beyond the range of previously observed variability or that result from significant alterations of physical (structural) system characteristics become the new norm. To achieve this shift, hydrologists must become both synthesists, observing and analyzing the system as a holistic entity, and analysts, understanding the functioning of individual system components, while operating firmly within a well-designed hypothesis testing framework. Cross-disciplinary integration must become a primary characteristic of hydrologic research, catalyzing new research and nurturing new educational models. The test of our quantitative understanding across atmosphere, hydrosphere, lithosphere, biosphere, and anthroposphere will necessarily lie in new approaches to benchmark our ability to predict the regional hydrologic and connected implications of environmental change. To address these challenges and to serve as a catalyst to bring about the necessary changes to hydrologic science, we call for a long-term initiative to address the regional implications of environmental change.

Proceedings ArticleDOI
16 Oct 2010
TL;DR: Development needs for UX evaluation methods are revealed, such as early-stage methods, methods for social and collaborative UX evaluation, establishing practicability and scientific quality, and a deeper understanding of UX.
Abstract: The recent shift of emphasis to user experience (UX) has rendered it a central focus of product design and evaluation. A multitude of methods for UX design and evaluation exist, but a clear overview of the current state of the available UX evaluation methods is missing. This is partly due to a lack of agreement on the essential characteristics of UX. In this paper, we present the results of our multi-year effort of collecting UX evaluation methods from academia and industry with different approaches such as literature review, workshops, Special Interest Groups sessions and an online survey. We have collected 96 methods and analyzed them, among other criteria, based on the product development phase and the studied period of experience. Our analysis reveals development needs for UX evaluation methods, such as early-stage methods, methods for social and collaborative UX evaluation, establishing practicability and scientific quality, and a deeper understanding of UX.

Book ChapterDOI
01 Jan 2010
TL;DR: This chapter reviews a representative selection of multi-agent reinforcement learning algorithms for fully cooperative, fully competitive, and more general (neither cooperative nor competitive) tasks.
Abstract: Multi-agent systems can be used to address problems in a variety of domains, including robotics, distributed control, telecommunications, and economics. The complexity of many tasks arising in these domains makes them difficult to solve with preprogrammed agent behaviors. The agents must instead discover a solution on their own, using learning. A significant part of the research on multi-agent learning concerns reinforcement learning techniques. This chapter reviews a representative selection of multi-agent reinforcement learning algorithms for fully cooperative, fully competitive, and more general (neither cooperative nor competitive) tasks. The benefits and challenges of multi-agent reinforcement learning are described. A central challenge in the field is the formal statement of a multi-agent learning goal; this chapter reviews the learning goals proposed in the literature. The problem domains where multi-agent reinforcement learning techniques have been applied are briefly discussed. Several multi-agent reinforcement learning algorithms are applied to an illustrative example involving the coordinated transportation of an object by two cooperative robots. In an outlook for the multi-agent reinforcement learning field, a set of important open issues are identified, and promising research directions to address these issues are outlined.

Journal ArticleDOI
TL;DR: Uchida et al. as mentioned in this paper explain the spin Seebeck effect by spin pumping at the contact that is proportional to the spin mixing conductance of the interface, the inverse of a temperature-dependent magnetic coherence volume, and the difference between the magnon temperature in the ferromagnet and the electron temperature in normal metal.
Abstract: The spin Seebeck effect is a spin-motive force generated by a temperature gradient in a ferromagnet that can be detected via normal metal contacts through the inverse spin Hall effect [K. Uchida et al., Nature (London) 455, 778 (2008)]. We explain this effect by spin pumping at the contact that is proportional to the spin-mixing conductance of the interface, the inverse of a temperature-dependent magnetic coherence volume, and the difference between the magnon temperature in the ferromagnet and the electron temperature in the normal metal [D. J. Sanders and D. Walton, Phys. Rev. B 15, 1489 (1977)].

Book
02 Dec 2010
TL;DR: In this paper, the authors provide a concise introduction to the theory of graph spectra and its applications to the study of complex networks, covering a range of types of graphs and topics important to the analysis of complex systems.
Abstract: Analyzing the behavior of complex networks is an important element in the design of new man-made structures such as communication systems and biologically engineered molecules. Because any complex network can be represented by a graph, and therefore in turn by a matrix, graph theory has become a powerful tool in the investigation of network performance. This self-contained book provides a concise introduction to the theory of graph spectra and its applications to the study of complex networks. Covering a range of types of graphs and topics important to the analysis of complex systems, this guide provides the mathematical foundation needed to understand and apply spectral insight to real-world systems. In particular, the general properties of both the adjacency and Laplacian spectrum of graphs are derived and applied to complex networks. An ideal resource for researchers and students in communications networking as well as in physics and mathematics.

Journal ArticleDOI
TL;DR: An iterative algorithm is described that converges to the maximum likelihood estimate of the position and intensity of a single fluorophore and efficiently computes and achieves the Cramér-Rao lower bound, an essential tool for parameter estimation.
Abstract: We describe an iterative algorithm that converges to the maximum likelihood estimate of the position and intensity of a single fluorophore. Our technique efficiently computes and achieves the Cramer-Rao lower bound, an essential tool for parameter estimation. An implementation of the algorithm on graphics processing unit hardware achieved more than 10(5) combined fits and Cramer-Rao lower bound calculations per second, enabling real-time data analysis for super-resolution imaging and other applications.

Journal ArticleDOI
TL;DR: In this paper, a generalized likelihood function is presented to estimate both the parameter and predictive uncertainty of hydrologic models, which can be used for handling complex residual errors in other models.
Abstract: Estimation of parameter and predictive uncertainty of hydrologic models has traditionally relied on several simplifying assumptions. Residual errors are often assumed to be independent and to be adequately described by a Gaussian probability distribution with a mean of zero and a constant variance. Here we investigate to what extent estimates of parameter and predictive uncertainty are affected when these assumptions are relaxed. A formal generalized likelihood function is presented, which extends the applicability of previously used likelihood functions to situations where residual errors are correlated, heteroscedastic, and non?Gaussian with varying degrees of kurtosis and skewness. The approach focuses on a correct statistical description of the data and the total model residuals, without separating out various error sources. Application to Bayesian uncertainty analysis of a conceptual rainfall?runoff model simultaneously identifies the hydrologic model parameters and the appropriate statistical distribution of the residual errors. When applied to daily rainfall?runoff data from a humid basin we find that (1) residual errors are much better described by a heteroscedastic, first?order, auto?correlated error model with a Laplacian distribution function characterized by heavier tails than a Gaussian distribution; and (2) compared to a standard least?squares approach, proper representation of the statistical distribution of residual errors yields tighter predictive uncertainty bands and different parameter uncertainty estimates that are less sensitive to the particular time period used for inference. Application to daily rainfall?runoff data from a semiarid basin with more significant residual errors and systematic underprediction of peak flows shows that (1) multiplicative bias factors can be used to compensate for some of the largest errors and (2) a skewed error distribution yields improved estimates of predictive uncertainty in this semiarid basin with near?zero flows. We conclude that the presented methodology provides improved estimates of parameter and total prediction uncertainty and should be useful for handling complex residual errors in other hydrologic regression models as well.

Journal ArticleDOI
TL;DR: In this paper, a two-phase injection procedure is proposed to fix bacteria with their enzyme activity relatively homogeneously in a sand bed, before supplying cementation reagents, where a bacterial suspension is injected into the sand body, immediately followed by a fixation fluid (i.e. a solution with high salt content).

Journal ArticleDOI
TL;DR: A review of the state of the art and present status of active aeroelastic rotor control research for wind turbines is presented in this paper, where the authors discuss the potential of load reduction using smart rotor control concepts.

Journal ArticleDOI
TL;DR: In this article, the spin-pumping-induced voltages due to the inverse spin Hall effect in permalloy/normal metal bilayers integrated into coplanar waveguides for different normal metals and as a function of angle of the applied magnetic field direction, as well as microwave frequency and power.
Abstract: Spin pumping is a mechanism that generates spin currents from ferromagnetic resonance over macroscopic interfacial areas, thereby enabling sensitive detection of the inverse spin Hall effect that transforms spin into charge currents in nonmagnetic conductors. Here we study the spin-pumping-induced voltages due to the inverse spin Hall effect in permalloy/normal metal bilayers integrated into coplanar waveguides for different normal metals and as a function of angle of the applied magnetic field direction, as well as microwave frequency and power. We find good agreement between experimental data and a theoretical model that includes contributions from anisotropic magnetoresistance and inverse spin Hall effect. The analysis provides consistent results over a wide range of experimental conditions as long as the precise magnetization trajectory is taken into account. The spin Hall angles for Pt, Pd, Au, and Mo were determined with high precision to be 0.013±0.002, 0.0064±0.001, 0.0035±0.0003, and ?0.0005±0.0001, respectively.

Journal ArticleDOI
TL;DR: This research proves that models like TAM should not treat mobile services as a generic concept, but instead to specifically address individual mobile services, and demonstrates the unique value of combining objective usage measurements with traditional survey data in more comprehensively modelling service adoption.

Journal ArticleDOI
TL;DR: Information is provided about the validity of the Driver Behaviour Questionnaire that has strong relevance for researchers and road safety practitioners who seek to obtain insight into driving behaviors of a population of interest.

Posted Content
TL;DR: It is concluded that in general Maps constructed using VOS provide a more satisfactory representation of a data set than maps constructed using well-known multidimensional scaling approaches.
Abstract: VOS is a new mapping technique that can serve as an alternative to the well-known technique of multidimensional scaling. We present an extensive comparison between the use of multidimensional scaling and the use of VOS for constructing bibliometric maps. In our theoretical analysis, we show the mathematical relation between the two techniques. In our experimental analysis, we use the techniques for constructing maps of authors, journals, and keywords. Two commonly used approaches to bibliometric mapping, both based on multidimensional scaling, turn out to produce maps that suffer from artifacts. Maps constructed using VOS turn out not to have this problem. We conclude that in general maps constructed using VOS provide a more satisfactory representation of a data set than maps constructed using well-known multidimensional scaling approaches.

Journal ArticleDOI
TL;DR: The purpose of this study was to review all evidence for these methods, in order to provide a guideline for use in clinical practice.
Abstract: BACKGROUND: Surgeons are increasingly being scrutinized for their performance and there is growing interest in objective assessment of technical skills. The purpose of this study was to review all evidence for these methods, in order to provide a guideline for use in clinical practice. METHODS: A systematic search was performed using PubMed and Web of Science for studies addressing the validity and reliability of methods for objective skills assessment within surgery and gynaecology only. The studies were assessed according to the Oxford Centre for Evidence-based Medicine levels of evidence. RESULTS: In total 104 studies were included, of which 20 (19.2 per cent) had a level of evidence 1b or 2b. In 28 studies (26.9 per cent), the assessment method was used in the operating room. Virtual reality simulators and Objective Structured Assessment of Technical Skills (OSATS) have been studied most. Although OSATS is seen as the standard for skills assessment, only seven studies, with a low level of evidence, addressed its use in the operating room. CONCLUSION: Based on currently available evidence, most methods of skills assessment are valid for feedback or measuring progress of training, but few can be used for examination or credentialing. The purpose of the assessment determines the choice of method.

Journal ArticleDOI
TL;DR: In this paper, the authors use long-term monitoring data from the Mississippi?Atchafalaya River Basin (MARB) and the Baltic Sea Drainage Basin (BSDB) to show that inter-annual variations in loads (LT) for total?N (TN) and total?P (TP) exported from a catchment are dominantly controlled by discharge, leading inevitably to temporal invariance of the annual, flow?weighted concentration, Cf = (LT/QT).
Abstract: Complexity of heterogeneous catchments poses challenges in predicting biogeochemical responses to human alterations and stochastic hydro?climatic drivers. Human interferences and climate change may have contributed to the demise of hydrologic stationarity, but our synthesis of a large body of observational data suggests that anthropogenic impacts have also resulted in the emergence of effective biogeochemical stationarity in managed catchments. Long?term monitoring data from the Mississippi?Atchafalaya River Basin (MARB) and the Baltic Sea Drainage Basin (BSDB) reveal that inter?annual variations in loads (LT) for total?N (TN) and total?P (TP), exported from a catchment are dominantly controlled by discharge (QT) leading inevitably to temporal invariance of the annual, flow?weighted concentration, Cf = (LT/QT). Emergence of this consistent pattern across diverse managed catchments is attributed to the anthropogenic legacy of accumulated nutrient sources generating memory, similar to ubiquitously present sources for geogenic constituents that also exhibit a linear LT?QT relationship. These responses are characteristic of transport?limited systems. In contrast, in the absence of legacy sources in less?managed catchments, Cf values were highly variable and supply limited. We offer a theoretical explanation for the observed patterns at the event scale, and extend it to consider the stochastic nature of rainfall/flow patterns at annual scales. Our analysis suggests that: (1) expected inter?annual variations in LT can be robustly predicted given discharge variations arising from hydro?climatic or anthropogenic forcing, and (2) water?quality problems in receiving inland and coastal waters would persist until the accumulated storages of nutrients have been substantially depleted. The finding has notable implications on catchment management to mitigate adverse water?quality impacts, and on acceleration of global biogeochemical cycles.