Institution
Department of Biotechnology
Government•New Delhi, India•
About: Department of Biotechnology is a government organization based out in New Delhi, India. It is known for research contribution in the topics: Population & Silver nanoparticle. The organization has 4800 authors who have published 5033 publications receiving 82022 citations.
Papers published on a yearly basis
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TL;DR: This ubiquitous enzyme has been vastly commercialized and holds greater future prospects, including therapeutic advances in treatment of Fabry disease, blood group conversion and removal of α-gal type immunogenic epitopes in xenotransplantation.
50 citations
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TL;DR: In isolation and identification of the proteolytic bacteria from Gangotri glacier sediments, taxonomical characterization of the study isolates may serve as a base line data for taxonomic characteristics of the cold adapted protease producing microorganisms.
50 citations
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TL;DR: In this paper, the ability of Pleurotus spp., P. sajor-caju; P. platypus and P. citrinopileatus to treat pulp and paper mill effluent on a laboratory and pilot scale were studied.
Abstract: In this work, the ability of Pleurotus spp.:P. sajor-caju; P. platypus and P. citrinopileatus to treat pulp and paper mill effluent on a laboratory and pilot scale were studied. On the laboratory scale treatment, P. sajor-caju decolorized the effluent by 66.7% on day 6 of incubation. Inorganic chloride liberated by P. sajor-caju was 230.9% (814.0 mg/dl) and the COD was reduced by 61.3% (1302.0 mg/dl) on day 10 of treatment. In the pilot scale treatment maximum decolorization was obtained by P. sajor-caju (60.1%) on day 6 of the incubation. Inorganic chloride content was increased by 524.0 mg/dl (113.0%) and the COD was reduced by 1442.0 mg/dl (57.2%) by P. sajor-caju on day 7 of incubation. These results revealed that the treatment of pulp and paper mill effluent by P. sajor-caju proved as better candidate for the purpose than P. platypus and P. citrinopileatus.
50 citations
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TL;DR: Investigation on the mechanism of action of black tea theaflavins showed that they act directly on the virus particle and are able to inhibit cell-to-cell spread and hold promise for developing in therapeutic arsenal for HCV infection.
Abstract: The treatment of hepatitis C virus (HCV) infection by combination of direct acting antivirals (DAA), with different mode of action, has made substantial progress in the past few years. However, appearance of resistance and high cost of the therapy is still an obstacle in the achievement of the therapy, more specifically in developing countries. In this context, search for affordable antivirals with new mechanisms of action is still needed. Tea, after water, is the most popular drink worldwide. Polyphenols extracted from green tea have already shown anti-HCV activity as entry inhibitors. Here, three different theaflavins, theaflavin (TF1), theaflavin-3'-monogallate (TF2), and theaflavin-3-3'-digallate (TF3), which are major polyphenols from black tea, were tested against HCV in cell culture. The results showed that all theaflavins inhibit HCV infection in a dose-dependent manner in an early step of infection. Results obtained with HCV pseudotyped virions confirmed their activity on HCV entry and demonstrated their pan-genotypic action. No effect on HCV replication was observed by using HCV replicon. Investigation on the mechanism of action of black tea theaflavins showed that they act directly on the virus particle and are able to inhibit cell-to-cell spread. Combination study with inhibitors most widely used in anti-HCV treatment regimen demonstrated that TF3 exerts additive effect. In conclusion, theaflavins, that are present in high quantity in black tea, are new inhibitors of HCV entry and hold promise for developing in therapeutic arsenal for HCV infection.
50 citations
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TL;DR: The present study suggests that G. corticata and G. edulis contains important nutrients for human health and are possible natural functional foods.
Abstract: The present study sought to evaluate the nutritional composition and physicochemical properties of two dried commercially interesting edible red seaweeds, Gracilaria corticata and G. edulis. Proximate composition of the dried seaweeds revealed a higher content in carbohydrates (8.30 g/100 g), total crude protein (22.84 g/100 g) and lipid content (7.07 g/100 g) in G. corticata than in G. edulis. Fatty acids profile showed that G. corticata samples contain higher concentrations of saturated fatty acids, such as palmitic and stearic acids, and polyunsaturated ones such as α-linolenic and docosahexaenoic acids. Contrariwise, G. edulis contained higher amounts of monounsaturated oleic acid. Total amino acid content was 76.60 mg/g in G. corticata and 65.42 mg/g in G. edulis, being the essential amino acid content higher in G. edulis (35.55 mg/g) than in G. corticata (22.76 mg/g). Chlorophyll a was found in significantly higher amounts in G. edulis (17.14 μg/g) than G. corticata, whereas carotenoid content was significantly higher in G. corticata (12.98 μg/g) than in G. edulis. With respect to physical properties, both water- and oil-holding capacities were similar in both seaweeds, whereas swelling capacity was higher in G. edulis. In view of the results, the present study suggests that G. corticata and G. edulis contains important nutrients for human health and are possible natural functional foods.
50 citations
Authors
Showing all 4812 results
Name | H-index | Papers | Citations |
---|---|---|---|
Ashok Pandey | 96 | 796 | 43038 |
Klaus Becker | 79 | 320 | 27494 |
Bansi D. Malhotra | 75 | 375 | 19419 |
Ashwani Kumar | 66 | 703 | 18099 |
Sanjay K. Banerjee | 62 | 798 | 30044 |
M. Michael Gromiha | 56 | 352 | 10617 |
Swaran J.S. Flora | 55 | 267 | 11434 |
Mallappa Kumara Swamy | 54 | 864 | 14508 |
Pulok K. Mukherjee | 54 | 296 | 10873 |
Mukesh Doble | 51 | 364 | 9826 |
Jaya Narayan Sahu | 49 | 157 | 9569 |
Pradeep Das | 49 | 426 | 10118 |
Jon R. Lorsch | 48 | 117 | 7661 |
Rakesh Tuli | 47 | 165 | 7497 |
Amit K. Goyal | 47 | 157 | 5749 |