Department of Biotechnology

About: Department of Biotechnology is a government organization based out in New Delhi, India. It is known for research contribution in the topics: Population & Silver nanoparticle. The organization has 4800 authors who have published 5033 publications receiving 82022 citations.

Efficacy of nanoparticles as nanofertilizer production: a review.

Abstract: Owing to the ever-increasing demand for food, the growing global population has forced farmers to increase fertilizer use. The overall use of fertilizers increased by 13 times between 1950 and 2020, from 15 to 194 million tons. Due to the resource shortages of chemical fertilizers on the market, agricultural costs are rising drastically every day because they cause an adverse impact on the environment by releasing chemical particulates and run-off agriculture. Biofertilizers have thus become a safer supplement to increase crop production without doing any harm to the environment, as they are produced industrially from a selected community of microorganisms that either develop a mutually beneficial relationship with plants or are part of their rhizosphere. They still have some drawbacks, which led to the development of a new avenue for the application of nanotechnology-mediated nanofertilizers. Nanotechnology recommends significant prospects for tailoring nanofertilizer production. They are typically coated with desired chemical composition having controlled release and targeted delivery of effective nanoscale ingredients, ability to improve plant productivity and to minimize environmental pollutants. The present review focuses primarily on the usefulness of nanofertilizers, as well as its environmental and safety concerns. The research would also include useful knowledge related to the introduction of different forms of nanoparticles within the agricultural field, contributing to the opening of a new route to nanorevolution.

Degradation of anthropogenic pollutant and organic dyes by biosynthesized silver nano-catalyst from Cicer arietinum leaves.

Abstract: The work represents the potent catalytic activity of silver nanoparticles synthesized from Cicer arietinum (chickpea) leaf extract (CAL-AgNPs). Here, silver nano-catalysts were used against the anthropogenic pollutants mainly involving nitro-amines and azo dyes. These pollutants are extremely harmful to our environment and causes severe health issues. The CAL-AgNPs have the potential to degrade harmful toxins and their by-products, thereby decreasing the pollutants from the environment. The green synthesis of nano-catalyst includes a simple, cost effective and eco-friendly method using the leaf extract from the plant. A systematic study was conducted, including synthesis, optimization and characterization of the silver particles. The AgNPs were further assessed through DLS and TEM for size and morphological evaluation. The obtained particles have shown spherical morphology with the size range of 88.8nm. Further, FTIR were performed for compositional and functional group analysis of the particles. The antibacterial efficiency was also evaluated against E. coli and P. aeruginosa. For their catalytic evaluation, CAL-AgNPs were assessed for 4-nitrophenol, methylene blue and congo red. The results obtained through catalytic evaluation suggested that the CAL-AgNPs could be helpful to surmount the environmental pollution in a very effective manner.

Analyzing microarray data of Alzheimer's using cluster analysis to identify the biomarker genes.

Abstract: Alzheimer is characterized by the presence of senile plaques and neurofibrillary tangles in cortical regions of the brain The experimental data is taken from Gene Expression Omnibus A hierarchical Cluster analysis and TreeView were performed to group genes on the basis of the expression pattern The dynamic change of expression over time and diverse patterns of expression support the concept of a complex local milieu TreeView allows the organized data to be visualized List of 24 genes were obtained which showed high expression levels Three genes, SORL1, APP, and APOE, are suspected to cause Alzheimer’s whereas the other 21 genes are related to other diseases but may also be found to be associated with Alzheimer’s, and these are TMEM59, CCT4, IGF2R, SFPQ, PRDX3, RNF14, IDS, SSBP1, SYNE2, TXNL4A, STXBP3, SMARCB1, ULK2, AGTPBP1, FABP7, CALB1, H2AFY, COPA, SAP18, ATIC and SYNCRIP