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Institution

Department of Biotechnology

GovernmentNew Delhi, India
About: Department of Biotechnology is a government organization based out in New Delhi, India. It is known for research contribution in the topics: Population & Silver nanoparticle. The organization has 4800 authors who have published 5033 publications receiving 82022 citations.


Papers
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Journal ArticleDOI
TL;DR: In-vitro cell study shows that the fabricated scaffold provide suitable template for cellular attachment, spreading, biomineralization and collagen based matrix deposition, indicating strong potential of the composite scaffold for bone tissue regeneration, vascularization and reconstruction of defects.

41 citations

Journal ArticleDOI
TL;DR: This work is the first comprehensive study of wheat YSL transporters and would be an important resource for prioritizing genes towards wheat biofortification.
Abstract: Oligopeptide transporters (OPT) are integral cell membrane proteins that play a critical role in the transport of small peptides, secondary amino acids, glutathione conjugates, and mineral uptake. In the present study, 67 putative wheat yellow stripe-like transporter (YSL) proteins belonging to the subfamily of OPT transporters were identified. Phylogeny analysis resulted in the distribution of wheat YSLs into four discrete clades. The highest number of YSLs was present on the A genome and the chromosome 2 of hexaploid wheat. The identified wheat YSL genes showed differential expression in different tissues and during grain development suggesting the importance of this subfamily. Gene expression pattern of TaYSLs during iron starvation experiments suggested an early high transcript accumulation of TaYS1A, TaYS1B, TaYSL3, TaYSL5, and TaYSL6 in roots. In contrast, delayed expression was observed in shoots for TaYS1A, TaYS1B, TaYSL5, TaYSL12, and TaYSL19 as compared to control. Further, their expression under biotic and abiotic response emphasized their alternative functions during the plant growth and development. In conclusion, this work is the first comprehensive study of wheat YSL transporters and would be an important resource for prioritizing genes towards wheat biofortification.

41 citations

Journal ArticleDOI
TL;DR: The molecular diversity of chitin and its applications in enzyme immobilization, wound healing, packaging material, controlled drug release, biomedical imaging, gene therapy, agriculture, biosensor, and cosmetics are discussed.
Abstract: Chitin is a long unbranched polysaccharide, made up of β-1,4-linked N-acetylglucosamine which forms crystalline fiber-like structure. It is present in the fungal cell walls, insect and crustacean cuticles, nematode eggshells, and protozoa cyst. We provide a critical appraisal on the chemical modifications of chitin and its derivatives in the context of their improved efficacy in medical applications without any side effect. Recent advancement in nanobiotechnology has helped to synthesize several chitin derivatives having significant biological applications. Here, we discuss the molecular diversity of chitin and its applications in enzyme immobilization, wound healing, packaging material, controlled drug release, biomedical imaging, gene therapy, agriculture, biosensor, and cosmetics. Also, we highlighted chitin and its derivatives as an antioxidant, antimicrobial agent, anticoagulant material, food additive, and hypocholesterolemic agent. We envisage that chitin and chitosan-based nanomaterials with their potential applications would augment nanobiotechnology and biomedical industries.

41 citations

Journal ArticleDOI
TL;DR: Assessment of the mixed combination of coffee pulp waste and pineapple waste residues for cellulase production using newly isolated Acinetobacter sp.
Abstract: The aim of this study was to assess the mixed combination of coffee pulp waste (CPW) and pineapple waste (PW) residues for cellulase production using newly isolated Acinetobacter sp. TSK-MASC in solid state fermentation. Response surface methodology based Box–Behnken design (BBD) was employed to optimize variables such as pH, incubation time, concentrations of CPW and PW. The BBD design investigation showed a sound adjustment of the quadratic model with the experimental statistics. Statistics based 3-D plots were generated to evaluate the changes in the response surface and to understand the relationship between the enzyme yield and culture parameters. The higher production (888 U mL−1) was achieved after 60 h of incubation with 3.0 g L−1 of CPW and PW at pH 7.0.

40 citations


Authors

Showing all 4812 results

NameH-indexPapersCitations
Ashok Pandey9679643038
Klaus Becker7932027494
Bansi D. Malhotra7537519419
Ashwani Kumar6670318099
Sanjay K. Banerjee6279830044
M. Michael Gromiha5635210617
Swaran J.S. Flora5526711434
Mallappa Kumara Swamy5486414508
Pulok K. Mukherjee5429610873
Mukesh Doble513649826
Jaya Narayan Sahu491579569
Pradeep Das4942610118
Jon R. Lorsch481177661
Rakesh Tuli471657497
Amit K. Goyal471575749
Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
20231
202261
2021948
2020648
2019572
2018427