Institution
Department of Biotechnology
Government•New Delhi, India•
About: Department of Biotechnology is a government organization based out in New Delhi, India. It is known for research contribution in the topics: Population & Silver nanoparticle. The organization has 4800 authors who have published 5033 publications receiving 82022 citations.
Topics: Population, Silver nanoparticle, DPPH, Gene, Oxidative stress
Papers published on a yearly basis
Papers
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TL;DR: This study reveals that GBF1 is able to form a G-box-binding heterodimer with HY5 but not with HYH, and demonstrates the functional interconnections ofGBF1, HY5, and HYH in Arabidopsis seedling development.
78 citations
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TL;DR: The results indicate that Leea indica was a promising antioxidant and anticancer agent for DU-145 and PC-3 human prostate cancer cell lines, however, further studies are needed to conclude its therapeutic use.
Abstract: Background To determine the phytochemical constituents, antioxidant, and anticancer activities of Leea indica leaf extracts on DU-145 and PC-3 human prostate cancer cell lines. Methods Leaf sample was subjected to Soxhlet extraction method with increasing polarity of solvents, namely, chloroform, ethyl acetate, methanol, ethanol, and aqueous. Phytochemical screening was done using different biochemical tests. Quantitative analysis for phenol was determined by Folin–Ciocalteu reagent method. The antioxidant activity was tested using 2,2-diphenyl-1-picrylhydrazyl, ferric ion reducing power assay, and phosphomolybdenum assay. In vitro anticancer activity on DU-145 and PC-3 human prostate cancer cell lines was evaluated by (3-(4, 5-dimethyl thiazole-2yl)-2, 5-diphenyl tetrazolium bromide) MTT assay. Results Phytochemical screening confirmed the presence of phyto-constituents like alkaloids, flavonoids, glycosides, phenols, lignins, saponins, sterols, tannins, anthraquinone, and reducing sugar. Methanol and ethanol extracts exhibited higher phenolic content as compare to aqueous extract. Antioxidant capacities were shown highest in methanol and ethanol extracts based on the test performed. The methanol and ethanol leaf extracts were found to be selectively cytotoxic in vitro to (DU-145 and PC-3) prostate cancer cell lines with IC 50 values 529.44±42.07μg/mL and 677.11±37.01μg/mL for DU-145 and 547.55±33.52μg/mL and 631.99±50.24μg/mL for PC-3 respectively, while it had no cytotoxic effect on normal mice embryo fibroblast cells. Conclusion The results indicate that Leea indica was a promising antioxidant and anticancer agent for DU-145 and PC-3 human prostate cancer cell lines. However, further studies are needed to conclude its therapeutic use.
78 citations
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TL;DR: In this paper, an integrated biomass conversion concept of producing liquid biofuels from fresh water macroalgal biomass was investigated and the theoretical yield of conversion of fermentable sugars to bioethanol was estimated and found to be 61.0%.
78 citations
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TL;DR: In this paper, the adsorption of Pb(II) ions onto a biopolymer based composite, chitosan blended polyacrylonitrile (chitosans/PAN), has been studied in a batch mode operation.
78 citations
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TL;DR: In this article, a review of the recent trends involved in the photosynthesis of metallic nanoparticles and their effective use in controlling malaria, hepatitis, cancer, like various endemic diseases is presented.
77 citations
Authors
Showing all 4812 results
Name | H-index | Papers | Citations |
---|---|---|---|
Ashok Pandey | 96 | 796 | 43038 |
Klaus Becker | 79 | 320 | 27494 |
Bansi D. Malhotra | 75 | 375 | 19419 |
Ashwani Kumar | 66 | 703 | 18099 |
Sanjay K. Banerjee | 62 | 798 | 30044 |
M. Michael Gromiha | 56 | 352 | 10617 |
Swaran J.S. Flora | 55 | 267 | 11434 |
Mallappa Kumara Swamy | 54 | 864 | 14508 |
Pulok K. Mukherjee | 54 | 296 | 10873 |
Mukesh Doble | 51 | 364 | 9826 |
Jaya Narayan Sahu | 49 | 157 | 9569 |
Pradeep Das | 49 | 426 | 10118 |
Jon R. Lorsch | 48 | 117 | 7661 |
Rakesh Tuli | 47 | 165 | 7497 |
Amit K. Goyal | 47 | 157 | 5749 |