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Institution

Department of Biotechnology

GovernmentNew Delhi, India
About: Department of Biotechnology is a government organization based out in New Delhi, India. It is known for research contribution in the topics: Population & Silver nanoparticle. The organization has 4800 authors who have published 5033 publications receiving 82022 citations.


Papers
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Journal ArticleDOI
TL;DR: The present review explores the major types of multitudinous QS systems known in Gram-positive and Gram-negative bacteria and their roles in bacterial pathogenesis and drug resistance and highlights the recent advancements in discovery of promising new QS modulators and their efficiency in controlling infections caused by multidrug-resistant bacterial pathogens.

69 citations

Journal ArticleDOI
TL;DR: The role of enzymes in decolorizing an extensive variety of textile dyes is suggested, thereby, aiding in understanding the enzyme mechanisms in Bioremediation.

69 citations

Book ChapterDOI
01 Jan 2017
TL;DR: This chapter provides an overview of the degradation mechanisms of biodegradable polymers with particular emphasis on the main parameters affecting the degradation of polymeric biomaterials.
Abstract: The concept of biodegradable plastics is receiving significant attention with respect to solid waste accumulation. Enormous efforts have been made in revolutionizing degradable biological materials without any environmental pollution to substitute for oil-based traditional plastics. With the overuse of plastics and increasing pressure being placed on capacities available for plastic waste disposal, the requirement for biodegradable plastics and biodegradation of plastic wastes has obtained immense importance in recent years. Awareness of the impact on the environmental waste problem has awakened research in the area of degradable polymers. Considering the emerging environmental issues, the demand to develop a material that does not burden nature has increased. It is essential to study the microbial degradation of biopolymers to understand what is necessary for biodegradation and the mechanisms involved. Widespread investigations on the biodegradation of plastics have been carried out to overcome the environmental problems associated with synthetic plastic waste. This chapter provides an overview of the degradation mechanisms of biodegradable polymers with particular emphasis on the main parameters affecting the degradation of polymeric biomaterials.

68 citations

Journal ArticleDOI
TL;DR: Results suggest that saponins from in vitro cultures of the root explant of B. aegyptiaca can be used as a larvicidal agent against A. a egypti larvae.

68 citations

Journal ArticleDOI
TL;DR: A significantly higher number of patients in the MIP group achieved sputum culture conversion at fourth week compared to the placebo group, suggesting a role of MIP in clearance of the bacilli.
Abstract: Prolonged treatment of tuberculosis (TB) often leads to poor compliance, default and relapse, converting primary TB patients into category II TB (Cat IITB) cases, many of whom may convert to multi-drug resistant TB (MDR-TB). We have evaluated the immunotherapeutic potential of Mycobacterium indicus pranii (MIP) as an adjunct to Anti-Tubercular Treatment (ATT) in Cat II pulmonary TB (PTB) patients in a prospective, randomized, double blind, placebo controlled, multicentric clinical trial. 890 sputum smear positive Cat II PTB patients were randomized to receive either six intra-dermal injections (2 + 4) of heat-killed MIP at a dose of 5 × 108 bacilli or placebo once in 2 weeks for 2 months. Sputum smear and culture examinations were performed at different time points. MIP was safe with no adverse effects. While sputum smear conversion did not show any statistically significant difference, significantly higher number of patients (67.1%) in the MIP group achieved sputum culture conversion at fourth week compared to the placebo (57%) group (p = 0.0002), suggesting a role of MIP in clearance of the bacilli. Since live bacteria are the major contributors for sustained incidence of TB, the potential of MIP in clearance of the bacilli has far reaching implications in controlling the spread of the disease.

68 citations


Authors

Showing all 4812 results

NameH-indexPapersCitations
Ashok Pandey9679643038
Klaus Becker7932027494
Bansi D. Malhotra7537519419
Ashwani Kumar6670318099
Sanjay K. Banerjee6279830044
M. Michael Gromiha5635210617
Swaran J.S. Flora5526711434
Mallappa Kumara Swamy5486414508
Pulok K. Mukherjee5429610873
Mukesh Doble513649826
Jaya Narayan Sahu491579569
Pradeep Das4942610118
Jon R. Lorsch481177661
Rakesh Tuli471657497
Amit K. Goyal471575749
Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
20231
202261
2021948
2020648
2019572
2018427