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Institution

Department of Biotechnology

GovernmentNew Delhi, India
About: Department of Biotechnology is a government organization based out in New Delhi, India. It is known for research contribution in the topics: Population & Silver nanoparticle. The organization has 4800 authors who have published 5033 publications receiving 82022 citations.


Papers
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Journal ArticleDOI
TL;DR: In this paper, a simple green route was reported to prepare highly stable silver nanoparticles, and the aqueous leaf extract of Durio zibethinus reduces Ag+ to Ag0 in the presence of natural sunlight.

62 citations

Journal ArticleDOI
TL;DR: Compounds 4b, 4c, 4d, 4f and 4j were found more potent antibacterials against pathogenic microorganisms and compound 4j was found a promising antiproliferative agent against A549 and SK-MEL2 human melanoma cell lines.

62 citations

Journal ArticleDOI
TL;DR: This review is focussed on the complications associated with glutaminases side activity and use of glutaminase free enzymatic drug l-Asparaginase in treating ALL and the other developments related to the modification of the drug for quality treatment.
Abstract: Acute lymphoblastic leukaemia (ALL) is one of the leading types of malignant disorder seen in children. Viral infections, genetic factors and exposure to chemical carcinogens are some of the factors responsible for causing ALL. Treatment strategies followed for curing ALL include chemotherapy or radiation therapy, wherein, chemotherapy involves the use of the enzymatic drug l-Asparaginase. The enzyme can be produced from various plants, animals, bacterial and fungal sources but, among them, bacterial sources are widely used for production of this enzyme. The enzyme is non-human in origin having certain bottle necks with l-Asparaginase therapy in the form of side effects such as pancreatitis, thrombosis which are mainly due to glutaminase side activity. Hence, present-day research is mainly focussed on minimizing or completely eliminating the glutaminase activity of the enzyme l-Asparaginase. This review is focussed on the complications associated with glutaminase side activity and use of glutaminase free enzymatic drug l-Asparaginase in treating ALL and the other developments related to the modification of the drug for quality treatment.

62 citations

Journal ArticleDOI
TL;DR: Level of ligninolytic enzymes is playing a major role in degradation of dye, which is dependent on time of incubation and species of fungi.
Abstract: Total three Pleurotus species (P. ostreatus, P. sapidus, P. florida) was compared for ligninolytic enzyme production grown with Coralene Golden Yellow, Coralene Navy Blue and Coralene Dark Red azo dyes in liquid medium under shaking condition. The biodegradation competency varied from species to species and it was found that P. ostreatus, P. sapidus and P. florida to 20 ppm dye concentration shows 88, 92 and 98 % decolorization, respectively for all three dyes. Production pattern of laccase, manganese dependent peroxidase and lignin peroxidase were studied during the growth of the organisms for 10 days. Laccase was found to be the major extracellular ligninolytic enzyme produced by fungus with negligible detection of lignin peroxidases. In all concentration of three dye studied, maximum laccase activity was observed on day 8, for 20 mg/l of dye laccase specific activity was 1–1.58 U/mg in P. ostreatus, 0.5–0.78 U/mg in P. sapidus and 1–1.92 U/mg in P. florida. Different factors (dye concentration, pH, protein and sugar estimation) influencing the ability of Pleurotus species to degrade dyes is documented and degradation was attributed to microbial action irrespective of pH change. HPTLC analysis of samples indicated degradation of dyes into intermediate products. Level of ligninolytic enzymes is playing a major role in degradation of dye, which is dependent on time of incubation and species of fungi.

61 citations

Journal ArticleDOI
13 Jun 2014-PLOS ONE
TL;DR: The results propose the effectiveness of capsaicin in down-regulating VEGF expression in non-small cell lung carcinoma (NSCLC) cells in hypoxic environment and advocate the candidature of capsicin in exclusively targeting angiogenesis by down- Regulating V EGF in tumor cells to achieve more efficient and cogent therapy of resistant NSCLC.
Abstract: Lung cancer is the leading cause of cancer-related deaths worldwide. Despite decades of research, the treatment options for lung cancer patients remain inadequate, either to offer a cure or even a substantial survival advantage owing to its intrinsic resistance to chemotherapy. Our results propose the effectiveness of capsaicin in down-regulating VEGF expression in non-small cell lung carcinoma (NSCLC) cells in hypoxic environment. Capsaicin-treatment re-activated p53-SMAR1 positive feed-back loop in these cells to persuade p53-mediated HIF-1α degradation and SMAR1-induced repression of Cox-2 expression that restrained HIF-1α nuclear localization. Such signal-modulations consequently down regulated VEGF expression to thwart endothelial cell migration and network formation, pre-requisites of angiogenesis in tumor micro-environment. The above results advocate the candidature of capsaicin in exclusively targeting angiogenesis by down-regulating VEGF in tumor cells to achieve more efficient and cogent therapy of resistant NSCLC.

61 citations


Authors

Showing all 4812 results

NameH-indexPapersCitations
Ashok Pandey9679643038
Klaus Becker7932027494
Bansi D. Malhotra7537519419
Ashwani Kumar6670318099
Sanjay K. Banerjee6279830044
M. Michael Gromiha5635210617
Swaran J.S. Flora5526711434
Mallappa Kumara Swamy5486414508
Pulok K. Mukherjee5429610873
Mukesh Doble513649826
Jaya Narayan Sahu491579569
Pradeep Das4942610118
Jon R. Lorsch481177661
Rakesh Tuli471657497
Amit K. Goyal471575749
Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
20231
202261
2021948
2020648
2019572
2018427